ISIFUNDO ESIPHELELE - PDF
Umthombo
UMnyango Wezengqondo, i-University of Florida College of Medicine kanye neMcK Night Brain Institute, Gainesville, FL 32610-0256, USA. [i-imeyili ivikelwe]
abstract
I-nucleus accumbens, isiza ngaphakathi kwe-ventral striatum, idlala indima enkulu ekulameni imiphumela eqinisayo yezidakamizwa zokuhlukumeza, ukudla, ubulili, nezinye izidakamizwa. Kuyiqiniso, kuvame ukukholelwa ukuthi lesi sakhiwo sinika amandla ukusebenza kokukhuthazekile njengokudla, ukuphuza kanye nokuziphatha kocansi, okuvezwa yimivuzo yemvelo kanye nokunye ukukhuthaza okuqinile. Le ndatshana igxile ekuluthweni kwezemacansini, kepha sibonisa ukuthi kunendlela evamile yokusebenza eyisisekelo yemiphumela enamandla yonke imilutha enayo eshukumiselweni somuntu. Okusho ukuthi, ukushayela ngemvelo kungaba nezenzo ezijwayelekile zezakhi zofuzo, okuthi uma ziphazamisekile, kuholele ekuziphatheni okubi. Ngokusekelwa ukwesekwa okuningana kwesayensi, sengeza futhi ukuthi lezo zakhi zedopaminergic, kanye namanye ama-gene polymorphisms, ahlasela imiphumela yokuziphatha kwe-hedonic ne-anhedonic. Izifundo zeGenotyping sezivele zixhumanise ukuzibandakanya kwe-gene polymorphic nokuluthwa kotshwala nezidakwa nokukhuluphala ngokweqile, futhi silindele ukuthi izifundo ezizayo zokuqanjwa kwamakhompiyutha ngokuzayo zizohlinzeka ngobufakazi bezinhlangano ze-polymorphic ngokuhlanganiswa okuqondile koshicilelo lwezocansi olususelwa ekuhlolweni kwensimbi yomtholampilo. Sincoma ukuthi ososayensi nodokotela baqale ucwaningo lokuhlanganisa ukusetshenziswa kwamathuluzi we-neuroimaging ne-dopaminergic agonistic agents ukuqondisa izinhlobo ezithile ze-gene polymorphisms ngokuhlelekile ekuziphatheni kwe-hyper- noma i-hypo-sex behaviour.
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