Ọrịa ụbụrụ. 2014 Sep; 19 (9): 1037-43. dị: 10.1038 / mp.2014.58. Epub 2014 Jun 10.
Volkow ND1, Tomasi D1, Wang GJ2, Logan J2, Alexoff DL2, Jayne M1, Fowler JS2, Wong C1, Mee P3, Du C3.
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Dopamine na-egosi na nucleus accumbens dị mkpa maka ụgwọ ọrụ cocaine. N'ụzọ na-akpali mmasị, nchọpụta ihe ọmụmụ egosiwo na ọnụ ọgụgụ dopamine na-abawanye ụba na striatum (nke a tụlere dị ka njikọta nke (11) C] raclopride na ndị natara D2 / D3) na ndị na-eme ihe ọjọọ cocaine. N'ebe a, anyị na-enyocha ma nzaghachi na-adịghị mma nke dopamine gosipụtara mmetụta nke detoxification na enweghị cocaine-cues n'oge na-akpali akpali. Maka ebumnuche a, anyị mụrụ mmadụ iri isii na abụọ (62 ndị na-eme ihe cocaine na ndị nchịkwa 43) na-eji positron emission tomography na (19) C] raclopride (radioligand sensitive to endogenous dopamine) iji tụọ mmụba dopamine na-ebute site na ọgwụ methylphenidate na 11 na ndị na-eme ihe cocaine, anyị jikwa ụba dopamine na-abawanye mgbe ejiri ọgwụ methylphenidate na cocaine cue-video na video na-anọpụ iche. Na njikwa, methylphenidate mụbara dopamine na dorsal (mmetụta mmetụta 24; P <1.4) na ventral striatum (ọnọdụ nke accumbens) (mmetụta mmetụta 0.001; P <0.89), mana na ndị na-eme ihe na cocaine na-eme mkpesa methylphenidate mmetụta adịghị iche na placebo ma yiri ya cocaine-cues dị ma ọ bụ na ọ bụghị. N'ime ndị na-eme ihe cocaine n'agbanyeghị mmetụta dopaminergic gosipụtara nke ọma, mgbanwe methylphenidate na-emetụta na ventral striatum jikọtara ya na agụụ ọgwụ siri ike. Nchọpụta anyị kwekọrọ na akara ngosi belata site n'aka ndị natara D0.001 n'oge ịxicụbiga mmanya ókè na ndị na-eme ihe cocaine na-eme ihe n'agbanyeghị agbanyeghị ngosi, nke nwere ike itinye aka na ọgwụ ọjọọ.
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