M J Ọgwụ Mmanya. 2019;45(3):264-275. doi: 10.1080/00952990.2019.1569667.
Wscieklica T1, Le Sueur-Maluf L1, Prearo L2, Conte R3, Viana MB1, Céspedes IC4.
nkịtị
MGBE:
Ọrụ nke akụkụ ụbụrụ akọwapụtara nke gụnyere nsogbu ịṅụ mmanya na-aba n'anya, dị ka amygdala, hippocampus na prefrontal cortex, apụtala dị ka isiokwu mmasị n'ime afọ ndị na-adịbeghị anya. Ka o sina dị, ọrụ mpaghara ndị a na-enwekarị mgbagwoju anya site na mgbanwe dị iche iche, n'ime ha bụ usoro ịṅụ mmanya na-aba n'anya nke isiokwu ndị ahụ gosipụtara.
IHE:
Ọmụmụ ihe dị ugbu a gosipụtara mmetụta nke oriri ethanol afọ ofufo na-adịghị ala ala (20 sessions) na DeltaFosB immunoreactivity (DeltaFosB-ir) na amygdala, hippocampus na prefrontal cortex nke oke na-egosi mmasị dị elu na nke dị ala maka ethanol.
METHODS:
DeltaFosB-ir butere site na oriri ethanol afọ ofufo na-adịghị ala ala nwere ohere nke obere karama abụọ na ụdị ethanol 20% n'ime oke Wistar nwoke. A na-enyocha ìgwè atọ nke anụmanụ: njikwa (n = 6), mmasị dị ala (n = 8) na mmasị dị elu (n = 8) maka ethanol, nke abụọ a na-ekewa site na ụkpụrụ ha nke ịṅụ afọ ofufo nke ngwọta mmanya.
IHE:
Ihe oriri ethanol na oke oke mmasị na-abawanye DeltaFosB-ir na Central amygdala, CA1 na CA3 mpaghara nke hippocampus ma belata DeltaFosB-ir na prelimbic cortex na ihu cingulate cortex. N'aka nke ọzọ, na oke oke mmasị dị ala, oriri ethanol afọ ofufo na-adịghị ala ala belatara DeltaFosB-ir na medial amygdala, basolateral amygdala, dentate gyrus na anterior cingulate cortex.
Nkwenye:
Nsonaazụ dị ugbu a na-egosi na usoro ịṅụ mmanya dị iche iche jikọtara ya na usoro DeltaFosB-ir kpọmkwem na nhazi ụbụrụ nke na-arụ ọrụ dị mkpa n'ịchịkwa omume na ime mkpebi, ya bụ amygdala, hippocampus na prefrontal cortex.
AKWỤKWỌ: Ịṅụ mmanya na-aba n'anya; DeltaFosB immunoreactivity; amygdala; nchịkwa ethanol na-adịghị ala ala; hippocampus; prefrontal cortex
PMID: 30849242
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