Neuropsychopharmacology. 2016 Mar 16. doi: 10.1038 / npp.2016.39.
Ọbụ abụ BF1, Bubula N2, Li D2, Przybycien-Szymanska MM2, Bindokas VP3, Vezina P1,2.
nkịtị
Ikpugheghari ya na amphetamine ugboro ugboro na-eduga ma ọnọdụ mmekọ yana mmetụta nke anaghị akpakọrịta. Lee anyị tụlere ntinye aka nke mkpokọta neuronal na ngụkọta ngụ akwara (NAcc) n'omume ndị a. Exposedmụ anụmanụ kpughere IP amphetamine ma ọ bụ mpaghara ventral tegmental (VTA) gosipụtara nzaghachi azụmapụtara amamịghe mgbe ha gbasoro amphetamine izu ka emesịrị. Exposurezọ ụzọ abụọ ekpugheri rịrị elu ΔFosB na NAcc. Zationmata nkọwapụta ndị a nke 'osFosB + ndị a, ka ekpughere na amphetamine enweghị mmetụta na dendritic spain densriter ma ọ bụ nha, na-egosi na akwara ndị a anaghị enwe mgbanwe na dendritic spine morphology nke na-esonye na ngosipụta nke mmetụta uche adịghị mma. Nnwale ndị ọzọ kpebiri otú neurons na NAcc si eme ka ngosipụta nke ọnọdụ njikọ. Ejiri usoro mmụta ikpa oke na-ekpughe oke maka IP ma ọ bụ amata VTA ma ọ bụ Amerughị ma ọ bụ nke arụghị ọrụ na mbara ọhịa. Dịka a tụrụ anya, ma e jiri ya tụnyere Njikwa, paired rats na-elekọta IP amphetamine mechara gosipụta mmeghachi omume a na-enwe mgbe a na-eme ka nnu dị n'ọhịa, mmetụta na-agbakwunye mmụba nke c-Fos + neurons na NAcc medial. Kọwapụta mkpụrụ ndụ c-Fos + ndị a kpughere na ejiri oke jikọrọ ọnụ gosipụtara mmụba nke spines dendritic yana ugboro nke obere nha na NAcc. N'ụzọ dị iche, ejiri òké ejikọtara na mbụ nke VTA amphetamine egosipụtaghị njigide mmụọ ma ọ bụ nkwupụta c-Fos +. Na ngbakwunye, nsonaazụ ndị a na-egosi ọrụ maka c-Fos + neurons na ntụgharị uche NAcc na mgbanwe ngwa ngwa na morphology nke spendic dendrit ha na ngosipụta nke ịhapụ amphetamine-paired gbara ya gburugburu.
PMID: 26979294
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