N'ihu nke nicotine na-eto eto na-emetụta ọganihu cocaine mgbe emechara-ndụ na ụmụ oke (2016)

nkịtị

Oge uto na-anọchi anya oge mmepe pụrụ iche jikọtara ya na omume ịba ụba n'ihe egwu yana ịnwale ọgwụ ọjọọ, ọkachasị nicotine. Anyị chere na ikpughe nicotine n'oge ntorobịa nwere ike ịbawanye ohere maka ụgwọ ọrụ ọgwụ n'oge okenye.

Tnwalere echiche a, a na-emeso ụmụ oke ICR nwoke na usoro nicotine ma ọ bụ saline n'oge uto, a na-enyocha mmasị ha maka cocaine, morphine na amphetamine site na iji nlele ọnọdụ mmasị (CPP) n'oge okenye. 

Mgbanwe omume ogologo oge nke nicotine butere tụrụ aro ọrụ enwere ike nke ntụgharị mkpụrụ ndụ ihe nketa gbanwere. Ya mere, a na-eduzi immunoblot maka ΔFosB, onye òtù ezinụlọ Fos nke ihe odide ederede, na nucleus accumbens nke ụmụ oke ndị a.

Mice ejiri nicotine mesoo ya n'oge mmalite mana ọ bụghị n'oge uto gosipụtara mmụba na CPP maka cocaine, morphine na amphetamine mechara bụrụ okenye. Ahụghị mmetụta a na ụmụ oke ejiri usoro nicotine subchronic dị ka ndị okenye, na-atụ aro na ikpughe na nicotine kpọmkwem n'oge uto na-abawanye mmetụta na-akwụghachi ụgwọ nke ọgwụ ndị ọzọ na-eto eto. Agbanyeghị, ikpughe nicotine na-eto eto agbanwebeghị ntụzịaka nri na-atọ ụtọ nke ukwuu na ụmụ oke.

Nkwalite nke cocaine CPP site na nicotine na-adabere na ya ma gbochie ya site na pretreatment na nicotinic antagonists.

Na mgbakwunye, ikpughe nicotine n'oge ntorobịa kpalitere okwu ΔFosB ruo n'ókè ka ukwuu karịa ikpughe nicotine yiri ya n'oge okenye, yana mmụba nke locomotor na-eme ka cocaine na-eme ka ọ bụrụ okenye. Nsonaazụ ndị a na-egosi na ikpughe nicotine n'oge ntorobịa na-abawanye ụgwọ ọrụ ọgwụ na-akpata n'oge okenye site na usoro ndị nwere ike ịgụnye ntinye nke ΔFosB.

AKWỤKWỌ:

Oge uto; Cocaine; DeltafosB; Oke; Nicotine; Ụgwọ ọrụ