Neuroreport. 2014 Jun 18;25 (9): 688-92 . doi: 10.1097/WNR.0000000000000157.
Venebra-Muñoz A1, Corona-Morales A, Santiago-Garcia J, Melgarejo-Gutiérrez M, Caba M, Garcia-Garcia F.
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Ọnọdụ ịba ụba gburugburu ebe obibi nwere nsonaazụ dị mkpa na adịghị ike nke ọgwụ ọjọọ na-esote. Ọrụ dị ugbu a nyochara ma ikpughe na gburugburu ebe bara ụba (EE) na-ebelata iri onwe ya nke nicotine n'ọnụ. A na-edobe oke Wistar na gburugburu ọkọlọtọ (SE, oke anọ n'otu ọnụ ụlọ) ma ọ bụ na EE n'ime ụbọchị 60 mgbe a kwụsịrị ara. EE nwere anụmanụ asatọ ndị e debere n'ime ngịga buru ibu nke nwere ihe dị iche iche dị ka igbe, ihe ụmụaka ji egwuri egwu, na ihe ndị e ji ili ozu bụ́ ndị a na-agbanwe ugboro atọ n'izu.
Mgbe oge a gachara, anụmanụ na-ekpughere nicotine maka izu 3, ebe ụmụ anụmanụ na-ahọrọ n'efu n'etiti mmiri na ngwọta nicotine (0.006% na mmiri). A na-enyocha oriri mmiri kwa ụbọchị. A na-emekwa ΔFosB immunohistochemistry na prefrontal cortex na nucleus accumbens.
Oke nke otu EE riri obere nicotine ngwọta (0.25 ± 0.04 mg / kg / ụbọchị) karịa oke SE (0.54 ± 0.05 mg / kg / ụbọchị). EE mụbara ọnụ ọgụgụ nke ΔFos-immunoreactive (ΔFos-ir) mkpụrụ ndụ na nucleus accumbens core na shei na na prefrontal cortex, ma e jiri ya tụnyere ụmụ anụmanụ na ọnọdụ ọkọlọtọ.
Agbanyeghị, oke ekpughere na nicotine dị na SE gosipụtara mkpụrụ ndụ ΔFos-ir dị elu na nucleus accumbens core na shei karịa oke ndị anaghị ekpughere. Nri Nicotine agbanwebeghị mkpụrụ ndụ ΔFos-ir na mpaghara ụbụrụ ndị a na anụmanụ EE. Nsonaazụ ndị a na-akwado echiche nke mmetụta nchebe ga-ekwe omume nke EE na mmetụta ụgwọ ọrụ yana mmepe nke omume riri ahụ na nicotine.
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