Br J Pharmacol. 2017 Mar 6. doi: 10.1111/bph.13771.
López-Arnau R1, Luján MA2, Duart-Castells L1, Pubill D1, Camarasa J1, Valverde O2,3, Escubedo E1.
nkịtị
MGBE NA-ECHICHE:
3,4-Methylenedioxypyrovalerone (MDPV) bụ cathinone sịntetik nwere mmetụta psychostimulant siri ike. Ọ na-ahọrọ nke ọma na-egbochi onye na-ebugharị dopamine (DAT) ma bụrụ 10-50-fold karịa ike dị ka onye na-egbochi DAT karịa cocaine, na-atụ aro oke mkpagbu. Ebumnuche bụ isi nke ọmụmụ ihe a bụ iji nyochaa nsonaazụ nke mmalite (n'oge uto) MDPV ikpughe na psychostimulant, na-akwụghachi ụgwọ ma na-ewusi mmetụta nke cocaine kpatara na oke oke.
Uzo nnwale:
Ụbọchị iri abụọ na otu mgbe ọgwụgwọ MDPV gasịrị (1.5 mg·kg-1 , sc, ugboro abụọ kwa ụbọchị maka ụbọchị 7), a na-anwale ụmụ oke ndị toro eto na cocaine, na-eji ọrụ locomotor, mmasị ọnọdụ ọnọdụ na nchịkwa onwe onye (SA). N'otu aka ahụ, dopamine D2 Achọpụtara njupụta nnabata na nkwupụta nke c-Fos na ΔFosB na striatum.
Nsonaazụ dị mkpa:
Ọgwụgwọ MDPV kwalitere mmetụta psychostimulant na ntụzịaka nke cocaine. Nnweta nke cocaine SA agbanwebeghị na ụmụ oke ejiri MDPV mebere ya, ebe mgbawa enwetara n'okpuru mmemme oke na-aga n'ihu na iweghachite mgbe mkpochapụ dị elu na otu oke a. MDPV belatara D2 njupụta nnabata mana mụbaa okwu ΔFosB okpukpu atọ. Dị ka a tụrụ anya, nnukwu cocaine mụbara okwu c-Fos, mana ọgwụgwọ MDPV na-emetụta okwu ya na-adịghị mma. Nchịkọta ΔFosB jụrụ n'oge nkwụsị MDPV, ọ bụ ezie na ọ nọgidere na-ebuli elu na ụmụ oke toro eto mgbe a nwalere maka mmetụta cocaine.
NKWUBIOKWU NA MMỤTA:
MDPV ikpughe n'oge uto mere ka mgbanwe mgbanwe na-adịte aka na-emetụta nzaghachi nke cocaine na ụmụ oke ndị toro eto nke yiri ka ọ na-eduga na adịghị ike dị elu na ịṅụbiga mmanya ókè. Omume a jikọtara ya na mmụba nke ΔFosB.
PMID: 28262947
DOI: 10.1111/bph.13771
;