Neurosci Lett. 2015 Dec 3. pii: S0304-3940(15)30290-1. doi: 10.1016/j.neulet.2015.11.052
Zhang Q1, Liu Q2, Li T2, Liu Y2, Wang L3, Zhang Z4, Liu H4, Hu M5, Qiao Y6, Nwu H7.
nkịtị
Nnyocha n'ime afọ iri gara aga gosipụtara na onye na-anabata NMDA (NMDAR) nwere ọrụ dị mkpa na opiate-induced neural na plasticity omume. Tụkwasị na nke ahụ, achọpụtara mmụba nke protein dị ka FosB (FosB / ΔFosB) na-emetụta àgwà nkwụsị nke morphine. Otú ọ dị, mmekọrịta dị n'etiti NMDAR na FosB / ΔFosB na mpaghara ụbụrụ nwere mmetụta n'oge mwepu morphine bụ nke amachaghị. N'ime ọmụmụ ihe a, anyị bu n'obi nyochaa usoro NMDAR na ọkwa FosB / ΔFosB n'ọtụtụ mpaghara ụbụrụ yana ma ha metụtara mpaghara ụbụrụ nwere mmetụta n'oge abstinence morphine. A nabatara immunohistochemistry quantitative iji nwalee ọkwa NMDAR na FosB/ΔfosB n'oge mwepu morphine na oke. Achọpụtara ọkwa NMDAR na FosB / ΔFosB dị na nucleus accumbens core (AcbC), nucleus accumbens shell (AcbSh), Central amygdaloid nucleuscapsular part (CeC), ventral tegmental area (VTA) na cingulate cortex (Cg). Labeling immunofluorescence ugboro abụọ gosiri na NMDAR jikọtara ya na Fos/ΔFosB na mpaghara ise a. Nsonaazụ ndị a na-egosi na ọtụtụ mpaghara phenotypic bụ NMDAR na Fos / ΔFosB na-agbaziri n'oge mwepụ morphine, dị ka mkpali (AcbC, AcbSh), limbic (CeC, VTA) na ndị isi (Cg) ụzọ usoro, yana nwere ike ịbụ ebumnuche ebumnuche nke mbụ. NMDAR na Fos/ΔfosB nke na-emetụta omume iwepụ morphine.
AKWỤKWỌ: FosB protein; NMDA nnata; usoro limbic; morphine; ndọrọ ego
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