Neuropharmacology. 2016 Jul 9; 110 (Pt A): 135-142. doi: 10.1016 / j.neuropharm.2016.07.009.
Morais-Silva G1, Alves GC2, Marin MT3.
nkịtị
Itinye ọgwụ Ethanol bụ nsogbu ahụike siri ike ọhaneze nke chọrọ ọgwụgwọ ọgwụ ka mma. Isi ihe dị mkpa na mmepe na njikwa nke ọrịa a bụ ọbịbịa nke neuroadaptations na ụzọ ụbụrụ mesocorticolimbic maka mmetụ ethanol na-adịghị ala ala. Na mkpokọta, neuroadaptations ndị a bụ maladaptive ma na-emetụta ọtụtụ sistemụ neurotransmitter na ụmụ irighiri akwara intracellular.
Otu n'ime ụmụ irighiri ihe ndị a bụ ΔFosB, ntụgharị ntụgharị nke agbanwere mgbe ọgwụ ọgwụ na-adịghị ala ala gasịrị. Mmetụta omume bụ ezigbo ihe nlereanya maka ọmụmụ gbasara akwara ozi metụtara ọgwụ riri ahụ. Ọrụ ndị na-adịbeghị anya gosipụtara ọrụ maka nleghara anya nke glutamatergic neurotransmission na mgbaàmà ndị a hụrụ na ndị riri ahụ. N'echiche a, ọgwụgwọ ya na N-acetylcysteine, prodrug l-cysteine nke na-eme site na iweghachi extrasynaptik nke nri glutamate site na ịgbalite ọrụ antiplaer cystine-glutamate, egosila nsonaazụ na-ekwe nkwa na ọgwụgwọ nke ọgwụ riri ahụ. Ya mere, ejiri ihe nlere anya anụmanụ mee ihe iji nyochaa nsonaazụ N-acetylcysteine na-emetụta akparamagwa na mmegharị akwara sitere na nchịkwa ethanol na-adịghị ala ala. Icemụ Switzerland nọ n'okpuru 13 ụbọchị nke nchịkwa ethanol kwa ụbọchị iji mee ka mmata omume. Ka elekere abụọ tupu ethanol nke ethanol na ntule arụmọrụ locotor, ụmụ anụmanụ natara ọgwụ introperitoneally N-acetylcysteine.
Ozugbo oge ule ikpeazụ gachara, ewepụrụ ụbụrụ ha maka ΔFosB na cystine-glutamate antiporter quantification. Achọpụtara na ọgwụgwọ N-acetylcysteine gbochiri mmetụ omume ethanol, mmụba nke ọdịnaya ΔFosB na cortex prefrontal, yana mbelata ya na njakịrị akwara. Nsonaazụ a na-egosi na enwere ike iji N-acetylcysteine na nsogbu ọgbụgba ethanol.
AKWỤKWỌ:
Mmanya na-egbu egbu; Lutta nri; N-acetylcysteine; Nucleus na-akụta; Kortex prefrontal; mgbochi xCT
PMID:
DOI:
10.1016 / j.neuropharm.2016.07.009
;