Eur J Neurosci. 2016 Feb 1. doi: 10.1111/ejn.13193.
Herrera JJ1, Fedynska S2, Ghasem PR1, Wieman T1, Clark PJ1, Grey N2, Loetz E2, Campeau S3,4, Fleshner M1,4, Ụgwọ nke ụlọ ọrụ Greenwood BN1,4.
nkịtị
A na-etinye sekit ụgwọ ọrụ ụbụrụ na nsogbu mgbaka mgbakasị mgbakasị ahụ. Mmega ahụ na-ebelata nsogbu nke nsogbu ndị metụtara nrụgide, mana amabeghị onyinye nke mmega ahụ maka mmegide nrụgide. Nguzogide nrụgide na-emega ahụ na-adabere na njikwa mmega ahụ; ma wiil afọ ofufo na nke mmanye na-agba ọsọ na-echebe oke megide nchekasị- na ịda mbà n'obi dị ka omume omume nke nrụgide. Mmega ahụ afọ ofufo bụ ụgwọ ọrụ sitere n'okike, mana amaghi ma oke na-ahụta n'ụkwụ mmanye na-agba ọsọ na-akwụghachi ụgwọ. Ọzọkwa, onyinye nke dopamine (DA) na sekit ụgwọ ọrụ striatal iji nweta ụgwọ ọrụ amachaghị nke ọma.
E kenyere ndị okenye, oke oke n'otu ụkwụ akpọchiri akpọchi, ịgba ọsọ afọ ofufo (VR), ma ọ bụ ndị na-agba ọsọ mmanye (FR). A manyere oke oke FR ka ọ gbaa ọsọ n'ụkpụrụ yiri omume ịgba ọsọ ụkwụ nke oke.
Ma VR na FR mụbara ihe nrịbama plastik metụtara ụgwọ ọrụ ΔFosB na dorsal striatum (DS) na nucleus accumbens (NAc), yana mmụba nke DA neurons na mpaghara ventral ventral tegmental (VTA), dị ka ekpughere site na immunohistochemistry maka tyrosine hydroxylase. TH) na pCREB.
Ma oke VR na FR mepụtara mmasị ọnọdụ nwere ọnọdụ (CPP) n'akụkụ ọnụ ụlọ CPP jikọtara ya na mmega ahụ.
Nkpugheghachi n'akụkụ mmega ahụ jikọtara ọnụ nke ụlọ CPP na-ebute mmụba na cfos mRNA n'ụzọ ziri ezi (dynorphin-positive) neurons na DS na NAc na ma VR na FR rat, yana na TH-positive neurons na mpụta VTA. nke naanị oke VR.
Nsonaazụ na-egosi na mmetụta na-akwụghachi ụgwọ nke mmega ahụ na-adabere na njikwa mmega ahụ ma nye nghọta n'ime DA na sekit sekit na-etinye aka na ụgwọ ọrụ mmega ahụ na mmega ahụ na-akpata nrụgide nrụgide.
AKWỤKWỌ: Dopamine; mkpụrụ ndụ ihe nketa mbụ; oke; striatum; mpaghara ventral tegmental
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