Neurochem Res. 2013 Apr 13.
Lee DK, Oh JH, Shim YB, Choe ES.
Source
Ngalaba Nkà Mmụta Ihe Ọmụmụ, Pusan National University, 63-2 Pusandaehak-ro, Kumjeong-gu, Pusan, 609-735, Korea.
nkịtị
Ebido protein protein kinase G (PKG) na nhazi nke synaptic plasticity na ụbụrụ. A na-eduzi ọmụmụ ihe a iji chọpụta ntinye aka nke ndị na-anabata dopamine D2 (D2) metụtara PKG na nhazi nke ntọhapụ dopamine, okwu osFosB na ọrụ locomotor na nzaghachi maka ikpughe cocaine ugboro ugboro. Usoro ogwu cocaine (20 mg / kg) ugboro ugboro, otu ugboro n'ụbọchị maka ụbọchị asaa, na-arịwanye elu cyclic guanosine monophosphate (cGMP) na extracellular dopamine concentrations na dorsal striatum. Mgbochi nke neuronal nitric oxide synthase (nNOS), cGMP ma ọ bụ PKG na mkpali nke ndị natara D2 belatara cocaine ugboro ugboro na-eme ka ọnụọgụ dopamine. Enwetara nsonaazụ yiri ya site na ijikọta nOS, cGMP ma ọ bụ mgbochi PKG na mkpali nke ndị natara D2. N'iji data ndị a, mmechi PKG, ihe mkpali D2, na ijikọta igbochi PKG na mkpali nke ndị natara D2 belatara cocaine ugboro ugboro na-emewanyewanye na okwu ΔFosB na ọrụ locomotor.
Nchọpụta ndị a na-atụ aro na ịchịkwa ndị na-anabata D2 site na ọrụ PKG mgbe cocaine ugboro ugboro nwere ọrụ maka iwelie ntọhapụ dopamine na nkwado ogologo oge na nkwupụta mkpụrụ ndụ na ọdụ dopamine na gamma-aminobutyric acid neurons nke dorsal striatum, n'otu n'otu. Nzụlite a nwere ike itinye aka na mgbanwe akparamagwa na nzaghachi na mgbe ekpughere ekpomeekpo.
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