Na-egbu Biol. 2019 Aug 1: e12814. doi: 10.1111 / adb.12814.
van de Wetering R1, Schenk S1.
nkịtị
Exposureụ ọgwụ ọjọọ ugboro ugboro na-eweta plethora nke ụbụrụ na-agbanwe agbanwe, ụfọdụ n'ime ha na-amalite mmepe nke ọgwụ ọjọọ. Ebumnuche dị mkpa nke nyocha ọgwụ riri ahụ bụ ịchọpụta mgbanwe ụbụrụ nke nwere ike idozi mgbanwe site na iji ọgwụ ọjọọ eme ihe n'ụzọ na-adịghị mma. Nnọchi anya ihe na - akpata ntụgharị ahụ, ∆FosB, na - esochi ugboro ugboro ikpughe ọgwụ na - enye ụzọ iji mezuo ebumnuche a. Emere nyocha na ụmụ oke nwoke toro eto Sprague-Dawley. Ejiri mmetụta nke 3,4-methylenedioxymethamphetamine (MDMA) nchịkwa onwe ya na nha immunohistochemical nke ∆FosB mkpokọta na mpaghara ụbụrụ 12, atụnyere ndị otu, ọgwụ ọjọọ, otu njikwa. Otu ozo di ka MDMA (0.0 ma obu 10.0 mg / kg, ip, otu ugboro kwa ubochi maka ubochi 5), na ntinye ntinye nke MDMA (200 μg / side) microinused bilaterally n’ime mpaghara ụbụrụ ahọpụtara na ndabere nke ∆FosB Ekpebiri nsonaazụ nsonaazụ. Nlekọta MDMA na-abawanye ụba expressionFosB ngosipụta na nucleus accumbens isi, ventromedial na dorsomedial caudate-putamen, cingulate, prelimbic, infralimbic, na orbitofrontal cortex, na ma Central ma nke amygdala amị, ma ọ bụghị na akpa ego ma ọ bụ na-enweghị nsogbu caudate-. putamen. Mmụba na shei nucleus bụ ihe gbara ọkpụrụkpụ mana ọ bụghị ihe dị mkpa na-eso mgbazinye iwu maka ọtụtụ ntụnyere. MDMA mere nkwalite MDMA mepụtara hyperactivity naanị mgbe enyere ya n'ime ngọngọ akwara ma ọ bụ medial, mana ọ bụghị n'akụkụ, caudate-putamen, na-egosipụta nsonaazụ ∆FosB. Ihe omuma a tuputara nke oma na nsonaazụ a na-egosi ngbanwe ugboro ugboro na ọgwụ ọjọọ ndị ọzọ ma kwado echiche nke mgbanwe neuroplastic na-ahụkarị mgbe ekpughere ugboro ugboro ị drugụ ọgwụ ọjọọ.
AKWỤKWỌ: MDMA; mgbakwunye; ọrịa; mẹ ụnwanyi; njikwa onwe ya; FosB
PMID: 31373119
DOI: 10.1111 / adb.12814
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