Am J Arugụrụma Mmanya Na-aba n’anya. 2019; 45 (1): 84-89. doi: 10.1080 / 00952990.2018.1529182.
Sadat-Shirazi MS1,2, Babhadi-Ashar N1, Khalifeh S3, Mahboubi S2, Ahmadian-Moghaddam H1, Zarrindast MR1,4,5.
nkịtị
MGBE:
E wezụga mmetụta analgesic nke tramadol, ikpughe tramadol ruo ogologo oge nwere ike ime ka mgbanwe ndị na-agbanwe agbanwe si otú ahụ na-eduga n'ịdabere na ndidi. Tramadol na-ebute nsonaazụ ya site na µ-opioid receptor (MOR). Agbanyeghị, tramadol nwere ebumnuche ndị ọzọ dịka serotonin na epinephrine na-ebugharị.
IHE:
CREB na ΔFosB bu ihe ndi na ebute oria, nke sonyere na nmekpa aru a na-aria aru oru. Na omumu a, a nyochaputara nsonaazụ nke ọgwụgwọ tramadol na-adịghị ala ala na usoro MOR, ΔFosB, na CREB.
METHODS:
Maka ebumnuche a, ejiri ụmụ oke ụmụ nwoke Wistar 36. E kere anụmanụ ndị ahụ ụzọ abụọ. Onu ogugu anumanu 18 natara tramadol (0, 5, na 10 mg / kg) nke oma na umu anumanu 18 natara otu ihe ndia rue ubochi iri na ano. Otu awa mgbe ogwu ikpeazụ gasịrị, a na-ekpochapụ NAC na PFC ma debe -14 Celsius C na nitrogen mmiri. N'iji usoro nhichapu ebe ọdịda anyanwụ, enyocha ọkwa nke MOR, ΔFosB, na p-CREB.
IHE:
Na NAC, nnyonye anya tramadol na-abawanye ọkwa nke MOR na p-CREB. Ọzọkwa, nchịkwa tramadol na-adịghị ala ala na mpaghara a na-ebute ọkwa dị elu nke MOR, ΔFosB na p-CREB ma e jiri ya tụnyere oke bekee. Ọkwa MOR na p-CREB na PFC mụbara na mkparịta ụka tramadol na-adịghị ala ala na nke na-adịghị ala ala. Ọzọkwa, ọkwa ΔFosB mụbara naanị usoro nlekọta tramadol na-adịghị ala ala. Nsonaazụ gosipụtara na mgbanwe mgbanwe mere n'oge ekpughere ọgwụ.
Mmechi:
Anyị kwubiri na ma CREB na ΔFosB rụrụ ọrụ na ntanetị obi tramadol. Ọzọkwa, ọkwa MOR dị elu n'oge ọgwụgwọ tramadol nwere ike ịbụ n'ihi enweghị nchekasị nnabata.
AMAOKWU: CREB; Tramadol; ngwangwa ngụkọta; cortex prefrontal; nnabata op-opioid; FosB
PMID: 30632799
DOI: 10.1080 / 00952990.2018.1529182
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