Berry, Anne, UC Berkeley
Berry, Anne, UC Berkeley, https://orcid.org/0000-0002-5086-3643
[email protected], [email protected]
Bọchị mbipụta: Septemba 5, 2018
Onye mbipụta akwụkwọ: UC Berkeley
https://doi.org/10.6078/D1JM3K
Ntughari
Berry, Anne; Berry, Anne (2018), usoro Dopaminergic na-akpata mgbanwe dị iche na nchekasị àgwà: mgbakwunye, UC Berkeley Dash, Dataset, https://doi.org/10.6078/D1JM3K
nkịtị
Ejikọtara ọnya ọnya na ọrụ gbanwere n'ime ụzọ corticolimbic na-ejikọ amygdala na rostral face cingulate cortex (rACC), nke na-enweta ntinye dopaminergic bara ụba. Ọ bụ ezie na ọdịbendị a ma ama na-eji okwu ahụ “ahaghị nhata nke kemịkalụ” kọwaa pathophysiology nke ọnọdụ isi mmụọ dị ka nsogbu ụjọ, anyị amachaghị banyere otu ọdịiche ndị mmadụ n'otu n'otu na dopamine neurochemistry si emetụta mgbanwe na nchekasị na ọrụ dị na sekit corticolimbic. Anyị lebara okwu a anya site na inyocha ọdịiche dị na mwepụta dopamine na izu ike iji [11C] raclopride PET, njikọta ọrụ dị n'etiti amygdala na rACC na-eji izu ike fMRI, yana usoro ntụgharị uche na ụmụ mmadụ tozuru oke. Anyị hụrụ mmekọrịta na-adịghị mma n'etiti mwepụta dopamine na nchegbu trait nke na ndị mmadụ nwere nnwale dopamine dị elu na amygdala na rACC na-akọ akụkọ dị ala banyere onwe. Ejikọtara nrụpụta dị ala na mbelata ọrụ RACC-amygdala belata na ntọala. Ọzọkwa, njikọ arụ ọrụ gosipụtara mmekọrịta dị ala na nhapụ dopamine nke na ndị mmadụ nwere obere ọrụ RACC-amygdala na-arụ ọrụ gosipụtara ọkwa dị elu nke ntọhapụ dopamine na mpaghara ndị a. Na nchikota, nchoputa ndi a nyere aka na usoro hypodopaminergic nke nchegbu ma kwado ike ijikọ fMRI na usoro PET nke ọrụ neurochemical iji mee ka nghọta anyị banyere usoro emetụta mmetụta dị mkpa n’ime mmadụ.
ụzọ
Enyere ihe mgbakwunye, ebe a na-agụnye nyocha nke mwepụta dopamine na striatum yana mmekọrịta ya na nchekasị trait. Na mgbakwunye, anyị na-etinye nyocha nke mwepụta nke dosamine dopamine aka ekpe na njikọta egwuregwu funcitonal maka amygdala na rostral ihu ihu cingulate cortex.
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