J Neurol Sci. 2011 Nov 15;310 (1-2):53-7 . Epub 2011 Julaị 23.
Moriyama TS, Felicio AC, Chagas MH, Tardelli VS, Ferraz HB, Tumas V, Amaro-Junior E, Andrade LA, Crippa JA, Bressan RA.
Source
Instituto do Cérebro, Instituto de Ensino e Pesquisa do Hospital Israelta Albert Einstein, Sao Paulo, Brazil. [email protected]
nkịtị
Nsogbu nchekasị nke ọha na eze (SAD) bụ ihe a na-ahụkarị n'etiti ndị ọrịa PD karịa na ọha mmadụ. Enwere ike ịkọwa njikọ a site na usoro psychosocial mana ọ ga-ekwe omume na usoro neurobiological nke dị n'okpuru PD nwere ike ibute SAD.. Ebumnuche nke ọmụmụ a bụ iji nyochaa usoro dopaminergic enwere ike itinye aka na ndị ọrịa PD nwere SAD, site n'ịkọwa striatal dopamine transporter binding potential (DAT-BP) na oke mgbaàmà nchegbu ọha na eze na ndị ọrịa PD. iji SPECT na TRODAT-1 dị ka rediopharmaceutical.
Ndị ọrịa PD iri na otu nwere SAD zuru oke na ndị ọrịa 21 PD na-enweghị SAD gụnyere n'ọmụmụ ihe a; dakọtara otu maka afọ, okike, ogologo oge ọrịa na oke ọrịa. Achọpụtara nchoputa SAD dabere na njirisi DSM IV nke ejiri SCID-I na akara mgbakasị nchegbu ọha na eze dị na Brief Social Phobia Scale (BSPS). A chịkọtakwara data igwe mmadụ na ụlọ ọgwụ. Ejikọtara DAT-BP nke ọma na akara na BSPS maka putamen ziri ezi (r=0.37, p=0.04), putamen ekpe (r=0.43, p=0.02) na caudate aka ekpe (r=0.39, p=0.03). Ọnweghị njikọ dị ịrịba ama maka caudate ziri ezi (r=0.23, p=0.21).
Nchọpụta a nwere ike ime ka echiche ahụ dịkwuo ike na dysfunction dopaminergic nwere ike itinye aka na pathogenesis nke nchegbu ọha na eze na PD..
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