Ọrịa Ọrịa. 2014 Ọkt 1;76 (7):542-9. doi: 10.1016/j.biopsych.2014.01.013.
Der-Avakian A1, Mazei-Robison MS2, Kesby JP1, Nestler EJ3, Markou A4.
nkịtị
MGBE:
Anhedonia, ma ọ bụ mbelata mmasị ma ọ bụ obi ụtọ na mmemme na-akwụghachi ụgwọ, na-akọwa ịda mbà n'obi ma gosipụta mperi na sekit ụgwọ ọrụ ụbụrụ. Nchegbu ọha na eze na-ebute anhedonia ma na-abawanye ohere ịda mbà n'obi, ọ bụ ezie na mmetụta nke nrụgide mmekọrịta ọha na eze na ọrụ ụgwọ ọrụ ụbụrụ na-aghọtaghị nke ọma.
METHODS:
Ọmụmụ ihe a tụlere ihe ndị a: 1) ụgwọ ọrụ ụbụrụ na oke (iji usoro mkpali onwe onye intracranial) na ọkwa protein nke ụbụrụ ụbụrụ na-enweta neurotrophic na mkpụrụ ndụ ihe mgbaàmà metụtara ya na nzaghachi maka mmeri ọha mmadụ na-adịghị ala ala, 2) ụgwọ ọrụ ụbụrụ n'oge mmeri ọha mmadụ. na ọgwụgwọ ogologo oge na antidepressants fluoxetine (5 mg / kg / day) na desipramine (10 mg / kg / ụbọchị), na 3) ịmanye omume ule igwu mmiri mgbe mmeri ọha na eze na ọgwụgwọ fluoxetine.
IHE:
Mmeri ọha na eze na-ebelata nke ukwuu ma na-anọgidesi ike na-ebelata ọrụ ụgwọ ọrụ ụbụrụ, na-egosipụta nzaghachi anhedonic na-adịgide adịgide, na oke ndị nwere ike ime ya, ebe oke na-agbanwe agbanwe egosighi mperi ụgwọ ọrụ ụbụrụ ogologo oge. Na mpaghara ventral tegmental, mmeri nke ọha mmadụ, n'agbanyeghị ihe nwere ike ime ma ọ bụ nkwụghachi azụ, mbelata ihe na-akpata neurotrophic ụbụrụ na-abawanye na AKT phosphorylated, ebe ọ bụ naanị nhụsianya na-ejikọta ya na phosphorylated mammalian target of rapamycin. Fluoxetine na desipramine tụgharịrị dị ala, mana ọ bụghị elu, mbelata ụgwọ ọrụ ụbụrụ na-akpata nchekasị na oke ndị nwere ike ịdaba. Fluoxetine belatara enweghị ike imeghari na ule igwu mmiri amanye, dịka mmeri ọha mmadụ mere.
Nkwenye:
Nsonaazụ ndị a na-egosi na mmeghachi omume anhedonic dị iche iche na-adịgide adịgide na nrụgide psychosocial nwere ike bụrụ onye ogbugbo site na mpaghara ventral tegmental nke na-egosi ụmụ irighiri ihe na-adabere na ụbụrụ neurotrophic nke ụbụrụ na-enweta ma na-egosi na anhedonia na-akpata nrụgide na-ejikọta ya na iguzogide ọgwụgwọ antidepressant. Ntụle nke omume ndị a na ihe ndị na-ahụ maka neurobiological jikọtara ya na iguzogide nrụgide na ọrụ antidepressant nwere ike ịkwalite nchọpụta nke ihe mgbaru ọsọ ọhụrụ iji na-emeso nsogbu mmetụta uche metụtara nchekasị.
Copyright © 2014 Society of Biological Psychiatry. Elsevier Inc. bipụtara. Ikike niile echekwabara.
AKWỤKWỌ:
Anhedonia; BDNF; ICSS; ịda mbà n'obi; mTOR; nrụgide
;