Psychopharmacology (Berl). 2018 Aug 22. nke a: 10.1007 / s00213-018-5007-4.
Lamontagne SJ1, Melendez SI1, Olmstead MC2,3.
nkịtị
Akụkụ:
Anhedonia, ụkọ iji rụọ ọrụ ụgwọ ọrụ, bụ ngwụcha nke ọtụtụ ọnọdụ akwara ozi. N’agbanyeghi ngbasa ya na ihe na-egbu ya ike, usoro ọgwụgwọ anhedonia enweghị, nke ka nke bụ na a naghị aghọta usoro ndị ọ na-akpata. Dopamine (DA) ka etinyere ya na anhedonia site na ọrụ ya na mmụta metụtara ụgwọ ọrụ; Usoro glucocorticoid nwekwara ike itinye aka na anhedonia na-ebutekarị nrụgide na-adịghị ala ala.
IHE:
Ọmụmụ ihe a nyochare usoro DA na glucocorticoid na anhedonia site na iji ụdị oke ọrụ ọrụ puru iche (PRT).
METHODS:
A zụrụ azụ ụmụ oke Wistar oke na PRT wee nwalee ihe ndị a: (1) ịgbalite ma ọ bụ mgbochi nke ọrụ DA na-akpata site na inphections amphetamine (AMPH) ma ọ bụ pramipexole (PRAMI), (2) nrụgide dị nro (CMS), ma ọ bụ (3) Sistemu glucocorticoid na-arụ ọrụ (dexamethasone (DEX)) ma ọ bụ mgbochi (mifepristone (Mife)).
IHE:
AMPH mụbara na PRAMI belatara mgbagha mgbagha, na-atụ aka ịkwalite ma belata ụgwọ ọrụ na DA agonism na antagonism, n'otu n'otu. CMS belatara mgbagha mgbaghara kama ọ bụ naanị n'ụdị oke oke. DEX belatara mgbagha omume, na-atụ aro na usoro glucocorticoid na-enye aka na anhedonia, n'agbanyeghị na glucocorticoid inhibition (Mife) enweghị mmetụta. Onweghi nke aghụghọ a gbanwere ike ịchọpụta na ịzaghachi ihe mkpali nwere njikọ.
Nkwenye:
Nsonaazụ ndị a gosipụtara ọrụ nke DA na anhedonia ma gosipụta onyinye nke usoro glucocorticoid na mmetụta a. Na mgbakwunye, nrụgide na-adịghị ala ala nwere ike igbochi ọrụ DA na-arụ ọrụ nke ọma, na-eduga n'ọmụmụ metụtara ụgwọ ọrụ ụfọdụ anụmanụ ụfọdụ. Ihe nchoputa a nwere ike iduzi ọgwụgwọ anhedonia n'ọdịnihu site na ichigharị usoro DA na glucocorticoid, yana mmekorita enwere ike n'etiti ha.
AKWỤKWỌ: CMS; Depression; MDD; Reward; Stress
PMID: 30136143
DOI: 10.1007/s00213-018-5007-4
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