Psychopharmacology (Berl). 2016 Jan 14.
Freund N1,2, Thompson BS3, Sonntag K3, Meda S3, Andersen SL3.
nkịtị
Akụkụ:
Mmụba ọrụ nke prefrontal D1 dopamine receptors (D1R) na-etinye aka na omume metụtara ụgwọ ọrụ achọtara na ọrịa bipolar na ọgwụ riri ahụ. Ọ bụ ezie na amaara mmetụta nke D1R dị elu, omume ịda mbà n'obi na-emekwa na nsogbu ndị a mgbe nchọta ụgwọ ọrụ kwụsịrị.
IHE:
Ebumnobi bụ ịkọwapụta ka nkwụsị nke oke okwu D1R si emetụta omume ịda mbà n'obi.
METHODS:
A na-eji vector lentiviral (Tet.On) eme ihe iji megharịa okwu nke mkpụrụ ndụ DRD1 na glutamate neurons n'ime prefrontal cortex na nwoke, oke oke. A mụrụ ihe omume mmekọahụ na mmasị sucrose na ma D1R dị elu ON yana obere steeti OFF dị ntakịrị. Na-esochi nkwụsị nke steeti D1R ON, a na-ekpebi omume ịda mbà n'obi na steeti OFF. A na-eji nkwupụta nke onye na-achịkwa transcriptional, cyclic AMP-responsive element-binding protein (CREB), cyclic dị ka ihe na-egosi mmetụta mgbada na nucleus accumbens (NA).
IHE:
NA okwu D1R mụbara mmekọ nwoke na nwanyị nke laghachiri na ntọala na steeti OFF. Mmasị sucrose mụbara ~ 6% na steeti ON mana dara 11% n'okpuru ọkwa njikwa mgbe agbanyụrụ. N'ikwekọ n'ụdị phenotype nke ịda mbà n'obi, D1R OFF wedara ọrụ site na 40%, mebie ikike ịchịkwa (43%) yana mkpali ịgbanarị ujo (27 % karịa nsogbu) metụtara dsRed Gbanyụọ. CREB mụbara 29% na NA na steeti D1R OFF metụtara steeti ON.
Nkwenye:
Usoro akwụkwọ akụkọ a na-egosi na okwu D1R dị elu mụbara omume hedonic, ebe nkwụsị nke oke okwu D1R na-ebutekarị omume ịda mbà n'obi. Nlebanya ndị a na-akwado ọrụ maka ịgba ígwè okwu D1R na omume na riri ahụ metụtara bipolar.
AKWỤKWỌ:
Ihe riri ahụ; Ọrịa bipolar; Hedonia; Lentivirus; Prefrontal cortex; Oke
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