Psychopharmacology (Berl). 2004 Jul; 174 (3): 381-8 . Epub 2004 Febụwarị 7.
Czoty PW1, Morgan D, Shannon EE, Ngwa HD, Nader MA.
nkịtị
Akụkụ:
Egosiputara ọkwa mmekọrịta mmadụ na-emetụta dopamine (DA) D (2) ọrụ nnata yana adịghị ike na nchịkwa onwe nke cocaine na enwe cynomolgus. Emebere ọmụmụ ihe ugbu a iji gbasaa nchoputa ndị a iji kwado nkwado cocaine na ndị na-anabata DA D (1).
IHE:
Nyochaa mmetụta nke agonist D (1) dị elu na omume enweghị ọnọdụ (anya na-egbuke egbuke) na agonist D (1) dị ala na nchịkwa onwe nke cocaine, yana mmetụta nke ikpughe cocaine na D (2) onye na-anabata ya. na-arụ ọrụ n'ofe ọha mmadụ, dị ka positron emission tomography (PET) siri kpebisie ike.
METHODS:
Mmetụta dị elu D (1) agonist SKF 81297 na cocaine (0.3-3.0 mg/kg) na nchapụta ozugbo bụ na enwe asatọ n'oge oge nlele 15-min. Na-esote, a na-enyocha ike nke D (1) agonist SKF 38393 (0.1-17 mg / kg) iji belata nchịkwa onwe nke cocaine (0.003-0.1 mg / kg kwa injection, IV) na 11 enwe na-azaghachi n'okpuru a ofu-ratio 50 nhazi oge. N'ikpeazụ, a na-enyocha ọkwa nnabata D (2) na caudate na putamen na enwe iri na itoolu na-eji PET.
IHE:
SKF 81297, ma ọ bụghị cocaine, mụbara nke ukwuu n'ikiri enwe niile, na-enwe ike dịtụ ukwuu na enwe na-achị. SKF 38393 dose-dabere na-ebelata ọnụego nzaghachi cocaine na-eji ike omume na ịdị irè n'ofe ọkwa ọha. Mgbe akụkọ ihe mere eme nke nchịkwa cocaine buru ibu, ọkwa nnabata D (2) adịghị iche na ọkwa ọha.
Nkwenye:
Nsonaazụ ndị a na-egosi na ọrụ nnata D (1) anaghị emetụta ya nke ukwuu site n'ọkwá ọha na enwe si n'òtù ọha guzosiri ike. Ọ bụ ezie na nnyocha e mere na mbụ gosiri na enwe ndị na-achị achị nwere ọkwa ndị na-anabata D (2) dị elu ma ghara inwe mmetụta na-eme ka cocaine dị ike n'oge mkpughe mbụ, nchọpụta dị ugbu a na-egosi na iji cocaine ogologo oge gbanwere D (2) ọkwa nnabata dị ka D. (2) Ọrụ nnabata na nkwado cocaine adịghị iche n'etiti ọkwa ọha. Nchọpụta ndị a na-egosi na ikpughe cocaine belata mmetụta nke ụlọ mmadụ na ọrụ nnata DA.
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