Pharmacol Biochem Behav. 2013 Oct 12. pii: S0091-3057(13)00238-4. doi: 10.1016/j.pbb.2013.10.004.
Bijlsma EY, Chan JS, Olivier B, Veening JG, Millan MJ, Waldinger MD, Ihe kpatara RS.
Source
Utrecht Institute for Pharmaceutical Sciences na Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584CA Utrecht, Netherlands.
nkịtị
Mmekọahụ mmekọahụ na-akpata antidepressant na-emetụta ndụ nke ndị na-eji ọgwụ antidepressant nke ọma ma na-ebelata nnabata na ọgwụgwọ. Ụdị anụmanụ na-enye usoro nkuzi maka nyocha mmetụta mmetụta mmekọahụ nke ọgwụ ọhụrụ nwere. Ntụleghachi a na-atụle nkwụsi ike na mmeghari nke usoro nyocha anyị ahazi nke na-enyocha nnukwu, subchronic na adịghị ala ala mmetụta nke ogige psychoactive na ule 30minute mating. Na mgbakwunye, anyị na-enye nkọwapụta nke mmetụta nke ọtụtụ antidepressants dị iche iche (putative) na omume mmekọahụ oke nwoke, dị ka a nwalere na usoro nyocha anyị. Site n'ịtụle mmetụta nke ọgwụ antidepressants ndị a dị iche iche (paroxetine, venlafaxine, bupropion, buspirone, DOV 216,303 na S32006), nyochaa a na-atụle usoro ntinye nke na-akpata mmetụta mmekọahụ nke antidepressants na nhazi ha.
Nyocha a na-egosi na omume mmekọahụ na-egbochikarị site na antidepressants nke na-abawanye serotonin neurotransmission site na mgbochi nke ndị na-ebu serotonin, ebe ndị na-ebuwanye ọkwa nke dopamine na noradrenaline enweghị mmetụta mmekọahụ. Enweghị ike ịhazi nsogbu mmekọahụ ndị ahụ site na ịba ụba noradrenaline neurotransmission n'otu oge, mana a na-ahazi ya site na ịbawanye ma noradrenaline na dopamine neurotransmission. Ya mere, a na-eche na mmetụta mmetụta mmekọahụ nke ndị na-emechi ihe nchịkwa serotonin nke nhọrọ nwere ike ịgbado site na mmetụta mgbochi ha na akara dopamine na sekit ụbụrụ mmekọahụ. Ya mere mmepe ụlọ ọgwụ nke antidepressants ọhụrụ kwesịrị ilekwasị anya na mkpokọta ndị na-abawanye ma serotonin na dopamine mgbaàmà n'otu oge.
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