Ejiri Bingeing: Ụkpụrụ nke Omume Na-agabiga Akwụsịtụ? (2006)

IWU: Dika akwukwo a si kwuo, oke oke bu ezigbo ihe nlere anya nke ndi mmadu riri ahu - ma na omume. Inye nri na oke nri na akuko oge obula na - agba ume. Mụ banyere ụbụrụ nke oke oke ndị a na-ekpughe neurobiology nke ahụ riri ahụ maka ụmụ mmadụ.

Ọmụmụ ihe zuru oke: Oke oke: Model nke Oke Oke Oke Ebere?

PMCID: PMC1769467

NIHMSID: NIHMS15066

nkịtị

Omume na-agbagwoju anya (IEB) na-egosi ụdị nsogbu mmadụ dị iche iche gụnyere iri nri, ịṅụ ọgwụ ọjọọ, ịṅụbiga mmanya ókè, mmekọahụ ịkwa iko, na ịgba chaa chaa na-agba chaa chaa. Ọrịa na-akpata ọrịa ọgbụgba nọ n'etiti IEB, na ọnụọgụ ọgwụgwọ ndị dị oke dị. Ojiji nke ụdị omume ịme bingeing na usoro ihe oriri ndị ọzọ na-amalite ịkọwa ọdịiche dị n'azụ na ọdịiche dị n'etiti IEB na-eduzi inweta na iri nri na IEB na-eduzi maka ịchọta na ịṅụ ọgwụ ọjọọ. Nnyocha site na ụlọ a na-eji usoro ịnweta binge-type nwere ike inye ọhụrụ IEB.

Keywords: Nri Bing, Nrụpụta ihe, Ụdị omume

Kedu ihe na-emekarị, àgwà oke?

Omume na-adịghị mma (IEB) na-egosipụta ọrịa dị iche iche nke mmadụ gụnyere iri nri, ịingụ ọgwụ ọjọọ, ị alcoholụbiga mmanya ókè, omume rụrụ arụ na ịgba chaa chaa. Omume ndị a jikọtara ya na nrịanrịa na ọnwu na-abawanye, mana a na-echekwa ya n'agbanyeghị agbanyeghị nsonaazụ ọjọọ metụtara ha. N'ime iri afọ ole na ole gara aga, elebara anya ka ukwuu maka ịghọta ihe mgbakwasị ụkwụ na-emetụta usoro nke oke omume, na-agbasi mbọ ike na mbenata ị reducingụ ọgwụ ọjọọ na oke oriri. Olileanya bu na ichota ihe omuma nke ihe ojoo (dika inye nri) ga eme ka anyi ghota ihe omuma ndi ozo (dika ogwu ojoo). Nke a ga - eweta ihe ndabere maka mmepe nke usoro ọgwụgwọ ọhụụ nwere ike ịba uru n'ọtụtụ nsogbu. Ọ bụ ezie na, akụkọ ndị na-adịbeghị anya na-egosi ọganihu na ọgwụgwọ ọgwụ nke ọrịa metụtara ịba ụba na ụfọdụ ịtionsụ ọgwụ ọjọọ, nhọrọ ọgwụgwọ ka dị oke ma ọnụọgụ nlọghachi dị elu (de Lima, Soares, Reisser, & Farrellde, 2002; ; ; ; ).

N'ime ụmụ mmadụ, IEB na-eduzi na iri nri nwere ike ịbụ nke kachasị mma na-eri nri. Nri iri Bing na-eri nri ntanetinye oge na obere oge n'ogo nke kariri otutu ndi mmadu ga eri na ihe ndi yiri ya. Ogwurugwu nwere ike ma ọ bụ nwere ike ghara ịgbaso ya site n'omume mmejọ dị ka vomiting ('purging'), ibu ọnụ, ma ọ bụ mmega ahụ. N'ihe oriri na-eri nri bingeing, binges na-eme ugboro ugboro n'ogologo ogologo oge ma jikọta ya na mmetụta nke njedebe na nchekasị obi ().

Binge na-eri nri ndị ọzọ na IEB ndị ọzọ. Dịka ọmụmaatụ, ndị na-achọ ọgwụgwọ maka ịṅụ mmanya na ịṅụ ọgwụ cocaine nwere nnukwu ọnụ ọgụgụ nke iri nri (; ), na ndị mmadụ na-achọ ọgwụgwọ maka nsogbu iri nri ndị na-egbu bingeing nwere ọtụtụ ọnụ ọgụgụ nke ịṅụ ọgwụ ọjọọ, karịsịa mmanya na cocaine (; ; ; ; ; ). A kọkwara mmekọrịta dị n'etiti oriri na ịgba chaa chaa ().

Mmekọrịta dị n'etiti IEB na-atụ aro na usoro ịhazi ụdị omume ndị a nwere ike isiwanye. A chọrọ ụdị anụmanụ iji nyochaa mgbanwe ndị mepere n'oge IEB, mmezi, na nlọghachite, na iji tụnyere ọdịiche na ọdịiche dị n'etiti IEB dị iche iche. Mkpụrụ ogbugba eji etinye ụgwọ ọrụ nkịtị dị ka ihe oriri na-adọrọ mmasị karịsịa n'ihi ikike ha nwere ikpughe mgbanwe ndị na-eme ma ọ bụrụ na mgbe ụfọdụ, ịmalite omume omume (dịka mgbe ụfọdụ bingeing) gbanwere dị ka ugboro ugboro, mmechi, mmebi omume omume rụrụ arụ (dịka bingeing ugboro ugboro). Ejirila ụdị omume omume nke ụdị binge-ụdị, bụ nke a nyochaworo n'oge na-adịbeghị anya (). Ojiji nke ihe ndị a na usoro ndị ọzọ na-amalite ịkọwa ọdịiche dị nro na ọdịiche dị n'etiti IEB na-eduzi nri na IEB na-eduzi iji ọgwụ ọjọọ eme ihe (dịka ọmụmaatụ, ; ; ; ; ; ; ; ; ).

Eke Bingeing na IEB

Usoro ntinye ohere

A na-eduzi nyocha a site na ụlọ a ka ịzụlite ụdị omume nke iri nri binge nke na-achọghị igbochi ike, iji belata ihe mgbagwoju anya nke ejikọtara na nri-ndapụ. Ya mere, a na-enye ụlọ ọrụ nyocha na mmiri zuru ezu na-edozi ahụ na mgbe niile na usoro iwu anyị. Iji mee ka ụdị iri binge-type, enwere ike ịnweta ebe a ga-esi enweta nri abụba (nri mkpirisi mmiri). Nchọpụta anyị egosila na, dị ka ohere nke mbelata mkpụmkpụ, njiri nke na-ebuwanye mkpụmkpụ n'oge oge 2-h oge ịnweta oge (; ; ; ). Mgbe oke nwere ike ịnweta ngwa ngwa maka 2 h ugboro atọ n'izu, nnweta n'oge oge 2-h dị elu, ya bụ, ụdị oke na-aga n'ihu na-eme mkpirikpi iri na 24 h. Ịmepụta ihe ndị a dị elu na-ewe banyere izu 4. Otú ọ dị, ozugbo e guzobere, a na-edozi omume ahụ n'ụzọ dị mfe. Usoro a na-enye ụzọ dị mfe ma dị ọnụ ala iji guzosie ike IEB nke a ga-echekwa maka ogologo oge. Ihe a na-ahụ siri ike ma nwee ntụkwasị obi, dịka anyị gosipụtara ya na nsogbu dị iche iche na ogo oke (), yana ụmụ nwoke na nwanyị (; ).

Rats na ịnweta mkpụmkpụ maka 2 h na Mon, Weds, Fri (MWF) n'izu ọ bụla anaghị akwụ ụgwọ maka mbupụ ike e mepụtara n'oge binge na 22 h na-eso ihe omume binge. Nke ahụ bụ, uru dị ukwuu n'oge 2-h binge na-eme ka ihe ngosi 24-h dị ukwuu n'ụbọchị binge. Otú ọ dị, na ụbọchị ndị na-abụghị nke binge, Otú ọ dị, ụbọchị 24-h a na-ebelata ume. N'ihi ya, a na-emepụta àgwà ọjọọ na mwepụta MWF, ọ bụ ezie na ha anaghị enweta nri; naanị ohere ha nwere na mkpụmkpụ na-ejedebe. Ụdị nri oriri na MWF oke dị iche na nke oke a nọgidere na-enwe na oge nkwụsị nke 2-h kwa ụbọchị. Nri oriri 24-h kwa ụbọchị na oke ndị ahụ adịghị iche na nchịkwa naanị na ọtụtụ ụbọchị.

Eziokwu ahụ bụ na ịbịanye na protocol na-ejideghị aka na-adaba site n'ịkwụsị ịnweta nri kachasị abụba dị oke mkpa, n'ihi na ihe oriri binge nke ụmụ mmadụ na-eri na-agụnye nanị ihe ndị a na-egbochi 'abụba' dị ka nri nri na nri (DSM-IV ; ; ; ; ). Ke adianade do, igbochi ohere inweta ihe oriri nri na-eme ka mmiri ha na-esote na nhazi ihe nyocha a na-achịkwa (). Eziokwu ahụ bụ na ọ bụ ihe oriri na-adịghị eri nri dị mkpa, dị ka iri nri na enweghị agụụ na-ejikọta na ụmụ mmadụ (). Omume nke ụmụ anụmanụ na usoro ịnweta ohere na-emetụta ihe oriri mmadụ, ọ bụkwa n'ụzọ yiri nke ahụ ka ụmụ mmadụ na-ata ahụhụ na-eri nri bingeing.

Peptides na-achịkwa oriri na-abaghị uru na-enweghị mmetụta n'okpuru ọnọdụ ohere ịnweta oke

Na protocols ndị na-abụghị nke binge, galanin na-akwalite nri oriri na-edozi ahụ mgbe a na-enye ya kpọmkwem n'ime oghere paraventricular nke hypothalamus (; ), na onye M40 na-agba mbọ na-eme ka ọ ghara ịdị na-eri ya (). Otú ọ dị, mgbe a nwalere ya n'ọnọdụ enweghị ohere ma ọ bụ na M40 emetụta oriri anụ ahụ (). Enwetara ihe yiri nke ahụ na enterostatin, echiche nke neuropeptide na-eme ka e nwee ụbụrụ na -). Nke ahụ bụ, n'okpuru ọnọdụ ohere ịnweta, enterostatin enweghi mmetụta na nri nri bara uru (; , ). Nchoputa ndia na egosi na neurobiology nke uru na abuba n'adighi ike inweta ohere di iche na neurobiology of intra fat under other conditions.

Ije Bingeing site na ohere nwere oke nwere ike iyi mmechi

Enyochala ọmụmụ ihe ugbu a iji chọpụta ihe ndị dị n'etiti uru abụba nke nwere ike ịnweta na IEB ọzọ, iji ọgwụ ọjọọ eme ihe. Akụkọ sitere na ndị ọzọ dị iche iche egosiwo na GABA-B agonist baclofen na-ebelata nchịkwa onwe onye na ụmụ anụmanụ (; ; ; leekwa Brebner, Phelan, & Roberts, 2002; , maka nlele anya), ma gosipụta nkwa ụlọ ọgwụ na ọgwụgwọ nke ọgwụ ọjọọ na ịdabere (; ; ; lee kwa ; , maka nyocha). Ihe ndị a na-emepụta n'oge a na-egosi na baclofen na-ebelata binge-ụdị oriri nke abụba na-ebute site na ohere dị oke na-enweghị ibelata oriri nke nnukwu abụba nri ma ọ bụ chow (). Nke a na-adọrọ mmasị n'ihi na ịṅụ ọgwụ na ịṅụ ọgwụ ọjọọ na -; ; ; ; ; ; ; ) na baclofen n'ozuzu ha enweghi mmetụta na ma ọ bụ mee ka nri na-eri nri na usoro anụ ọhịa ndị na-abụghị anụ ọhịa (; ; ; ; ; ; ; ; ). N'ịkọtara ọnụ, nchọpụta ndị a na-egosi na njirimara na-emepụta ihe na-emetụta ụdị iri nri, dị ka a na-egosipụta na protocol a na-ejighi oke, dị iche na nke iri nri na-adịghị. Kama nke ahụ, amaokwu ndị dị mkpa na IEB nke bingeing nwere ike ịdị na-ejikọta ya na ndị nọ na IEB nke iji ọgwụ ọjọọ eme ihe.

Mkpebi

A naghị aghọta nke ọma ihe na-adịghị mma nke ugboro ugboro, nke na-emekarị ka ọ ghara ịdị na-eme ihe. Otú ọ dị, ịtụgharị ihe àmà na-egosi na usoro ndị ọzọ nwere ike itinye aka na nsogbu ndị metụtara ụdị omume a. Nnyocha ndị a na ụlọ nyocha a egosiwo na ohere dị mkpirikpi nwere ike ime ka mkpịsị aka, ugboro ugboro, imebiga ihe ókè nke mkpụmkpụ anụ na-adịghị eri nri. Usoro nkwekọrịta dị mfe ma dị ọnụ ala, na omume ahụ yiri ụzọ ụfọdụ iji bingeing mmadụ. Ihe ngosi nke oge a na-egosi na ọhụụ na-adịghị ahụkebe na-adịghị mma na ọnọdụ binge-ụdị dị iche na ọnọdụ ndị na-adịghị mma, ọ pụkwara ịdị na-ejikọta ya na njiko. E nwere ugbu a ụdị ọgbụgba dịgasị iche iche nke nwere ike iji mee ka nghọta anyị banyere mgbanwe mgbanwe na mgbatị ahụ na-eme site na ịbanye na IEB. Nchọpụta dị otú ahụ dị oké egwu ma ọ bụrụ na anyị ga-eme ka usoro dị iche iche na-enye aka na mmepe, mmezi, na nlọghachi azụ na omume ndị a na-ebibi ihe mgbe niile.

Nkweta

E gosipụtara na Society for the Study of Ingestive Behavior (SSIB) Satellite Symposium, Hueston Woods Resort, Ohio, Julaị 18-20, 2004. Onye oche nke Allan Geliebter na Harry R. Kissileff. Satọdee kwadoro akụkụ ụfọdụ site na New York Obesity Research Center, SSIB, General Mills Foods, McNeil Nutritionals, Ortho-McNeil Pharmaceuticals, Procter & Gamble.

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