Prog Neuropsychopharmacol Biol Ọrịa. 2020 Apr 20; 99: 109864. doi: 10.1016 / j.pnpbp.2020.109864. Epub 2020 Jan 15.
Mascia P1, Wang Q1, Brown J1, Nesbitt KM2, Kennedy RT3, Vezina P4.
nkịtị
N'oge na-adịbeghị anya, anyị kọrọ na nucleus accumbens (NAcc) dopamine (DA) na-agbagha usoro a na-ejighị n'aka n'oge onye ọrụ na-aza maka saccharin na-enweghị caloric. Anyị gosikwara na ikpughere ugboro ugboro na ọnọdụ a na-ejighị n'aka, dị ka ikpughe ọgwụ ọjọọ eme ihe, na-eduga na ịma ọkwa nke locomotor na NAcc DA nke amphetamine ma na-akwalite njikwa onwe ya nke ọgwụ. N'ebe a, anyị na-atụle nyocha ndị a na ndị ọzọ na-egosi na akara nrịbama nke NAcc na-emetụtakwa ụdị nsogbu ahụ. A na - ahụ maka ọkwa gligam na extracellular dị na saịtị a maka imi na-arịọ maka saccharin na usoro na - arịwanye elu na - agbakwunye na - agbakwunye na - agbakwunye na - emewanyewanye mgbanwe n'etiti arụmọrụ onye na - akwụ ụgwọ na - akwụ ụgwọ. Ọzọkwa, mmetụta uche na-azaghachi na maka amphetamine na-esochi ikpughe na ejighị n'aka na-esonyere ọkwa nke Ca2+/ proteinodase-based protein kinase II (CaMKII) na protein kinase C (PKC) phosphorylation yana gbanwere protein protein nke transFosB (ụba) na ndị na-ebugharị glutamate 1 (GLT1; belatara) na anụ ahụ NAcc. Dị ka ihe atụ, phosphorylation nke CaMKII na PKC na-achịkwa ịzụ ahịa na nnata nke AMPA na saịtị a, buliri elu na-esote mkpughe psychostimulant, ọ dịkwa mkpa maka ngosipụta nke ị drugụ ọgwụ ọjọọ. A na-ahụta ∆FosB na-abawanye na ọkwa GLT1 na-esochi ngosipụta nke psychostimulant, jikọtara ya na ị drugụ ọgwụ na ịba ụba, na-amarakwa ịmegharị ndị nnabata AMPA na ọkwa extracellular glutamate dị iche iche. Mmeghari ndị a na nnyefe glutamate yana ndị a hụrụ ya na DA na-esochi ugboro ugboro na-ekpughere ọnọdụ na-ejighị n'aka yiri nke a na-amịpụta site na ikpughe ọgwụ ọjọọ. Ha abụọ, ha rụtụrụ aka na iwebata ma DA na afọ ojuju na-edenye ụzọ na NAcc na ma ọgwụ ọjọọ yana omume riri ahụ. Dị ka ejighị n'aka dị ka ihe egwuregwu dị na ntanetị, ihe nchoputa ndị a nwere mkpa maka nsogbu ịgba chaa chaa mara amara iji gosipụta ọgwụ ọjọọ.
AKWỤKWỌ: Amphetamine; Dopamine; Amblinggba chaa chaa; Lutta nri; Nnyocha; Amaghi ihe
PMID: 31952958
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