Akụkụ na-agba aghara nke Ọrịa Na-achịkwa Mmetụta (2006)

Ndị amị North. Akwụkwọ edemede; dị na PMC Mar 7, 2007.

E bipụtara na ụdị edetu ikpeazụ:
PMCID: PMC1812126
NIHMSID: NIHMS13952
Jon E. Grant, JD, MD, MPHa,* na Marc N. Potenza, MD, PhDb
Mbubre ọhụụ nke onye bipụtara edemede a dị na Psychiatr Clin North Am
Hụ ihe ndị ọzọ na PMC na ebe isiokwu e bipụtara.

Okwu ikpe

Anna, nwanyị nke lụrụ nwanyị dị afọ 32, kọwara onwe ya dị ka onye "mmanye." Ọ kọrọ akụkọ, malite na mbubreyo nwata, nke aka na-enweghị nchịkwa. Ọ na-akọ na n'ime ọnwa ole na ole ọ nọrọ “na-echegharị” ohi, na-eche maka ya “ụbọchị niile.” Ọ na-akọ na ịsa aka ya malitere mgbe ya na ndị enyi ya zuru ohi, na ọnwa ole na ole, malitere. ihe fọrọ nke nta ka ọ bụrụ ememe ụbọchị ọ bụla, nke o ji aka ya mee. Anna na-akọ na ọ na - asa ngwa ngwa otu ugboro abụọ kwa izu. Ọ na-akọ “oke” ma ọ bụ “ọsọ” oge ọ bụla o zuru ohi. N'ụzọ bụ́ isi, o zuru ngwaahịa dị ọcha, dị ka shampoo na ncha. Ọ na-ezu ohi nsụgharị nke otu ihe. Anna na-akọ na ya nwere igbe nke otu ihe ncha ntutu na ncha ahụ zoro ezo na akwa ya. Ọ na-ezuru ncha ntutu na ncha ọ na-anaghị eji ma zụta ncha ntutu na ncha ọ masịrị ya n’ụlọ ahịa ọzọ. Mgbe a jụrụ Anna ihe mere na ọ tụfuru ncha ntutu ahụ, Anna na-akọ na inwe ngwaahịa ndị a "na-akasi ya obi". Ntụtụaka Anna nwere ike iri 2 ruo 3 elekere n'otu oge. Anna kowakwara echiche nke ubochi nile ma gbaa ya ume ka O buru ya ụzọ na akwado oge 3 rue 4 kwa ubochi. O nwedịrị ike ịhapụ ọrụ n'oge, na-enweghị ọrụ ndị ọ na-emezughị, ka o wee nwee ike ịbanye n'ụlọ ahịa zuo ihe. Ọzọkwa, ọ ghaara di ya ụgha, na-agwa ya na ọ na-azụta ihe ndị o zuru. Anna na-akọ na ọ dị “mmanye” ya na ihe ndị dị egwu.

Anna ọ na-arịa ọrịa uche (OCD) ma ọ bụ kleptomania? Omume ya ọ bụ nke na-eme mmanye, na-akpali akpali ka ọ bụ nke abụọ? Olee otú ịkọwapụta omume ya ga-esi lebara omume Anna anya? Anna enwere ike irite uru kariri n ’oke nziputa nke serotonin reuptake inhibitor, ma obu mmetu obi ma obu naltrexone ga adi nma karie?

A kọwapụtara impulsivity dị ka ihe ga - eme ka mmeghachi omume ọsọ ọsọ, nke a na - akwadoghị na mmeghachi omume nke ime ma ọ bụ n'èzí na - enweghị nhịahụ maka nsonaazụ ọjọọ [1]. Agbanyeghi na ụfọdụ nsogbu ụfọdụ ka emepụtara nke ọma dị ka nsogbu nchịkwa (ICDs), nsị anụ ahụ bụ isi ihe na-akpata ọtụtụ nsogbu uche (dịka ọmụmaatụ, iji ihe eji eme ihe, nsogbu ọgbụgba, ihe na - emetụta oke elele hyperactivity).

Ndi American Psychiatric Association na akowaputa ihe dika ihe mmeghari akparamagwa agwa na ebumnuche nke ibelata ma obu igbochi nchekasị ma obu nkpagbu, obughi inye gi obi uto ma obu imeju gi.2]. Agbanyeghị na OCD nwere ike bụrụ ọrịa kacha pụta ìhè na njiri mara ndị mmadụ, ihe mkpakọ bụkarị mgbaàmà n'ọtụtụ nsogbu uche (dịka ọmụmaatụ, iji ihe eji eme ihe, nsogbu mmadụ, schizophrenia) [3].

Fọdụ atụlewo ngalaba nke ịkpa ike na mkparị dịka ihe na-emegide ya, mana mmekọrịta ahụ yiri ka ọ ga-agbagha. Isi ike mmụọ na ihe omume nwere ike ibikọ n'otu oge n'otu nsogbu ahụ ma ọ bụ n'oge dị iche iche n'otu nsogbu ahụ, si otú ahụ na-agbagha ma nghọta na ọgwụgwọ nke akparamagwa ụfọdụ. A na - achọpụta na ICDs, nsogbu ndị a na - ahụkarị site na ịkpa ike, ka achọpụtara n'oge na - adịbeghị anya nwere atụmatụ nke compulsivity. Ebumnuche dị mkpa nke isiokwu a bụ ịchọpụta otú nchịkọta si dị na ICD. N'ime usoro a, isiokwu ahụ nyochakwara mmekọrịta dị n'etiti OCD na ICD.

Kemgbe ụwa, otu echiche banyere ICD abụwo akụkụ nke ihe na-akpali agụụ mmekọahụ [4]. Nghọta mbu a nke ICD sitere na data dịnụ na njiri mara nke ọrịa a, usoro mgbasa nke ezinụlọ, na azịza ọgwụgwọ ọgwụ na psychosocial. N'ime akwụkwọ nyocha na nyocha nke ọgụgụ isi, mbipụta anọ, ederede edegharịrị (DSM-IV-TR), ụdị ndị ICD na-abụghị ebe ọzọ edepụtara ugbu a gụnyere nsogbu ihe mgbawa na-apụtakarị, kleptomania, pyromania, pathological ịgba chaa chaa (PG), na trichotillomania. A na-ekwupụta nsogbu ndị ọzọ maka nnabata dabere na ndapụta, ọgwụ, na ikekwe myirịta yiri: psychogenic excoriation (ịkpụ ahụ), ịzụrụ mmanye, iji Intanet ịmanye, na omume mmekọahụ na-abụghị paraphilic. Ruo ókè nke ndị ICD ndị a na-ekerịta ụlọ ọgwụ, mkpụrụ ndụ ihe ọmụmụ, ihe ndị dịnụ, na njirimara bayoloji nke ọma. Agbanyeghị na ICD ka na-adịchaghị eleba anya, nyocha nke nsogbu ndị a amụbaala n'oge na-adịbeghị anya. Ihe omuma sitere na ihe omuma ndi a na-egosi nmekorita dikwa egwu di n'etiti ICD na OCD, agwa di iche n’etiti ICD, yana ihe di nkpa n’agha n’agbata isi ike ya. Maka nyocha siri ike na ọtụtụ ICD nwere oke, isiokwu a lekwasịrị anya na PG na trichotillomania, ndị ICD abụọ natara nlebara anya nyocha. Ọ na - enyochakwa kleptomania, nke, n'agbanyeghị na amachaghị ya karịa ọrịa ụbụrụ ndị ọzọ, na - enweta nlebara anya na - arịwanye elu site n'aka ndị ụlọ ọgwụ na ndị nyocha. Isiokwu ahụ tụlere mmekọrịta dị n'etiti ICD ndị a na OCD, akụkụ ndị dị mkpa nke ICD, yana ihe nyocha ụlọ ọgwụ maka ịtụle nchịkọta na ICDs.

Ịgba chaa chaa

PG, nke e ji mara nkwụsi ike ma na-emekarị omume akparamaagwa, na-arụ ọrụ arụ ọrụ, belata ogo ndụ, yana oke ịgba akwụ ụgwọ, ịgba alụkwaghịm, na mkpọrọ.5]. PG na-ebido n’oge okenye, ebe ụmụ nwoke na-amalite ịmalite n’oge ha bụ nwata [6]. Ọ bụrụ na ahapụghị ya ọgwụgwọ, PG dị ka ọrịa na-adịghị ala ala.

Compulsivity na-ezo aka na akuko omume ugboro ugboro nke emere dika iwu ufodu si di ma obu n'uzo nzuzu, PG na nmekorita nke otutu ihe. A na-eji PG eme omume nkwupụta nke ịgba chaa chaa na mgbochi na-egbochi omume ahụ. Ndị nwere PG na-akọwakarị ịgba chaa chaa dị ka ihe siri ike iguzogide ma ọ bụ ịchịkwa, na nke a, PG yiri nke a na-eme ugboro ugboro, enweghị isi, na ememe achọghị OCD. Ọzọkwa, ndị nwere PG na-enwekarị ememe okpukpe metụtara ịgba chaa chaa (wdg., Yi uwe ụfọdụ mgbe ịgba chaa chaa ma ọ bụ ịgba chaa chaa na igwe ịgba ọtọ). Njikọ putara ihe ozo n'etiti PG na OCD bu ntinye obi nke ndi nwere PG itinye aka na oke, nke puru ime ihe ojoo nke n’eme ka nsogbu ghara idi n ’mmekorita ma o bu aka oru ma mee ka nsogbu diri mmadu.7]. Dị ka ọ dị na OCD, akparamagwa omume PG-ịgba chaa chaa na-abụkarị mkpagharị ma ọ bụ mkpali na-akpali akpali [8]. Ndị nwere PG na-akọkarị na agụụ ihe ha na-agba na-eme ka ha chee echiche, ụjọ, ma ọ bụ owu ọmụma [9,10].

Ọmụmụ ihe na-achọpụta na ndị ọ bụla nwere PG nwere ọnụego dị elu nke ndụ ha (60% –76%), nchegbu (16% –40%), na ndị ọzọ (23%) ICDs [5,11,12]. Udi onodi ihe omume n'etiti PG na OCD enwebeghị nkenke. Iji maa atụ, n’ihe atụ nke isiokwu nwere PG, ọnụego ndị na - eme OCD agbagoro site na 1% rue 20% [5], na ụfọdụ, mana ọ bụghị ihe niile, ọmụmụ na-achọpụta ọnụọgụ dị elu nke OCD (ihe dị ka 2%) karịa achọpụtara na ọnụọgụ mmadụ niile. Ọmụmụ ihe gbasara St.13]. Agbanyeghi na ihe omumu a anakọtara data na 1980s, obu ya bu ihe omumu a edeputara rue oge nke enyochale ihe nlebara anya ime obodo banyere DSM maka OCD na PG.

Ihe omumu banyere PG n’etiti ndi mmadu nwere OCD akukotachaghi ihe, odi n’etiti PG na OCD. Agbanyeghi na omumu banyere obere OCD egosiputala onu ogugu PG sitere na 2.2% rue 2.6% [14,15], nyocha emere n’oge na-adịbeghị anya banyere nnukwu mkpụrụedemede nke isiokwu ndị nwere isi OCD (n = 293) hụrụ ọnụego nke ugbu a (0.3%) na ndụ (1.0%) PG [16] nke ahụ dị elu karịa ndị bi n'ozuzu ha (0.7 – 1.6%) [13]. Nchọpụta ndị a na-adịbeghị anya kwekọrọ na ndị sitere na ihe atụ nke ihe karịrị mmadụ 2000 ndị nwere OCD nke ọnụego PG ugbu a na nke gara aga dị ala karịa 1% [17]. N'otu aka ahụ, ọmụmụ ezinụlọ nke OCD proband achọpụtaghị ihe akaebe nke mmekọrịta dị oke n'etiti OCD na PG ma ọ bụ OCD na ICD n'ozuzu (ewezuga nsogbu ejiji na nsogbu nri) [18].

Ihe omumu banyere ezinulo nke ihe ndi nwere PG nwere oke. Nwa na ndi isi ibe [19] nyochara isiokwu 17 nwere PG na 75 nke ndị ikwu mbụ. Ọmụmụ nyocha ahụ chọpụtara na 1% nke ndị ikwu nke ogo mbụ nwere OCD (nke dịka ọnụọgụ na mpaghara), ma e nweghị ya na otu n'ime njikwa ahụ. Ọ bụ ezie na ihe nlele ahụ pere mpe, ọmụmụ ihe ahụ ji otu njikwa yana ajụjụ ọnụ a haziri ahazi maka ndị isiokwu na ndị ikwu nke ogo mbụ. Dika n’ime ihe omumu nke OCD proband, omumu akwukwo banyere ihe banyere PG na ndi ikwu ha aghaputaghi njikọ n’etiti PG na OCD.

Ọ bụ ezie na n’elu PG na-ekerịta ọtụtụ ihe ndị dị na OCD, ihe ka ọtụtụ n’ime data na-egosi na njikọta n’etiti nsogbu ndị a adịghị elu. N'ihi ya, ọ dị ka PG nwere ọtụtụ mmanye atụmatụ mana anaghị esonye ya na oke OCD. Otu ihe mere eji achọpụta ihe nwere ike ịgụnye njedebe nke nchọpụta ọrịa. Ihe ozo, a bughi nkowa okwu nke onwe bu na agbanyeghi na a choputara ihe di nkpa na nsogbu obula, ihe ndi ozo banyere nsogbu a di iche. Ihe ọzọ a na-atụle bụ na akụkụ nke ịkpa ike nwere ike iche n'etiti nsogbu ahụ.

Esstụle compulsivity na OCD na PG na ndị ICD ndị ọzọ nwere ike ịkọwa ọrụ nke compulsivity na nsogbu ọ bụla. Ọ bụ ezie na ọtụtụ ọmụmụ enyochala nnwale na ihe ndị metụtara (dịka ọmụmaatụ na-achọ) na PG [5,20], ihe dịtụ ole na ole nyochara iwu nke compulsivity na PG. N'otu nnyocha (Padua Inventory), ndị gbara ịgba chaa chaa ama ama ama ihe dị elu karịa njikwa nkịtị karịa21]. Ọmụmụ ihe ọmụmụ nke na-adịbeghị anya na-anwa ịghọta akụkụ siri ike na nke PG ji Padua Inventory nyochaa isiokwu 38 tupu yana mgbe izu izu 12 nke ọgwụgwọ paroxetine [22]. Na Padua Inventory na - eme ntụgharị na mmanye ma nwee ihe anọ [23]:

  1. Njikwa arụmọrụ na-emetụta ọrụ iche echiche, nke na-enyocha ụrọ na enyo enyo
  2. Egwu nke ofufe
  3. Atule
  4. Njikwa mmachi na arụmọrụ ụgbọ ala nke na - ebugharị mkpali na nchegbu ndị metụtara omume moto, dị ka mkpali ike

Na nbido, ihe pf PG mgbajiri jikọtara ya na njiri mara nke mkpali ma nwekwaa ike (nke pụtara, ihe 1 na 4 nke Padua Inventory). N'oge ọgwụgwọ, ọtụtụ ihe banyere ogo ịba uru na ihe mkpalite belatara, na mbelata dị ukwuu hụrụ na ihe 1 nke Padua Inventory na ntinye mkpali nke Eysenck impulsivity Questionnaire [22]. Ọmụmụ ihe a na-atụ aro na ịkpa ike na ịkpa ike na PG na-emekọ ihe n'ụzọ dị mgbagwoju anya, na usoro nke ịkpa ike na mgbaru ọsọ nwere mkpa dabere na nsonaazụ ọgwụgwọ. Nchikota ihe ichota bu na nnughari ma obu nmekorita (ma obu ihe akuko nke obula) nwere ike igosiputa ihe oghachu maka PG.

Agbanyeghị na pathogenesis bụ ihe ngosipụta kachasị dị mma ma enwere nsogbu ọfụma, naanị nyocha pere mpe nyochara ihe ga-ekwe omume ụbụrụ nke PG, ihe akaebe ahụ na-atụkwa aro dị iche na nke ahụrụ na OCD. Nnyocha MRI na-arụ ọrụ nke ịgba chaa chaa na-agba ume na ụmụ nwoke ịgba chaa chaa pathologic na-atụ aro na PG nwere njirimara akwara (nke na-agbada agbada n'ime mpaghara cortical, basal ganglionic, na mpaghara ụbụrụ thalamic na isiokwu ndị nwere PG dịka e jiri ya tụnyere njikwa) dị iche na usoro mmegharị ụbụrụ a hụrụ na cue. omumu ihe omumu banyere OCD (ihe kariri ime cortico-basal-ganglionic-thalamic pressure) [24,25]. Ebe nyocha banyere neurobiology nke PG na-abawanye, mmekọrịta neurobiologic nke PG na OCD ka ga-abụ nke ruru eru. Ọmụmụ ihe gbasara usoro nke PG na OCD (dịka, ndị na-atụnyere ma na-ọdịiche nke isiokwu na-eji otu ụdị atụ ahụ) achọrọ.

Ọgwụgwọ ịgba chaa chaa pathological

Na mbu ka atara aro ka PG, dika OCD, nwere ike igosi nzaghachi preferensi nke serotonin reuptake inhibitors (SRIs). Ihe omuma sitere na nnwale ogwu eji eme ya emeghari anya nke puru iche nke SRI n’egwuregwu PG, enwebeghi isi.7], na ọgwụ na-egosi uru dị ukwuu karịa placebo na ụfọdụ mana ọ bụghị na ọnwụnwa ndị ọzọ nke SRIs [26-29]. Na mgbakwunye, PG gosipụtara nzaghachi nye ndị na-emegide opioid [30,31], ọgwụ ndị egosighi na ọ dị irè n'ịgwọ OCD. Emeghachiwo nzaghachi nke PG maka ọgwụ pharmacologic ezughị ezu iji chọpụta n'ụzọ doro anya nhọrọ ọgwụgwọ. Enwere ike iji oke nke ịkpokọta ịdọ aka dakọtara ọgwụgwọ ndị ọpụrụiche ya na ndị mmadụ nwere PG ma ọ bụ ndị tụlere ma ọ bụ ịkọ ihe ga-ebute ọgwụgwọ ga-enyocha.

Ọgụgụ isi na ọgwụgwọ omume na-eleba anya na ọnọdụ PG egosila uru mbido [32]. Usoro ọgwụgwọ cognitive-omume maka PG, mana, dị iche na mkpughe na ọgwụgwọ mgbochi ọgwụgwọ a na-eji maka OCD [33]. Usoro ọgụgụ isi na-elekwasị anya n'ịgbanwe nkwenye onye ọrịa banyere njikwa a hụrụ maka ihe omume kpebiri n'echeghị eche. Usoro ọgụgụ isi na-enyere onye ọrịa ahụ aka ịghọta na iwu nke ihe gbasara omume, ọ bụghị akparamagwa ịkpa agwa, na-achịkwa nsonaazụ nke ịgba chaa chaa. N’otu nnyocha, usoro ọgụgụ isi nke mmadụ rụpụtara mere ka ọnụ ọgụgụ ịgba chaa chaa belata ma nwekwuo njide onwe onye banyere ịgba chaa chaa ma e jiri ya tụnyere njikwa ndepụta nchere [34]. Ọmụmụ ihe nke abụọ nke gụnyere igbochi nlọghachi azụpụtara rụpụtara nkwalite mgbaàmà ịgba chaa chaa ma e jiri ya tụnyere njikwa ndepụta nchere [35].

Ejikwala ọgwụgwọ ọgụgụ isi maka ịgwọ PG. Akụkụ akparamàgwà na-akọwa nnọchi omume ndị ọzọ maka ịgba chaa chaa. Otu nnwale na-enweghị usoro atụnyere ụdị ọgwụgwọ anọ: (1) njikwa mkpali nke mmadụ n'otu n'otu na mgbochi vivo na nzaghachi mmeghachi omume, (2) nhazi njikwa, (3) njikọ nke 1 na 2, na (4) njikwa ndepụta ndepụta nchere. . Na ọnwa 12, ọnụọgụ ịwepu ma ọ bụ obere ịgba chaa chaa dị elu na usoro ọgwụgwọ onwe onye (69%) karịa na nhazi mmezi nke otu (38%) na nchịkọta ejikọtara (38%).36]. Nnwale nnwere onwe, nke a na-achịkwa, dabere na usoro ọgwụgwọ ọgụgụ isi nke ejiri mee ihe n'ịgwọ nsogbu nke iji ihe na-emetụta ihe yana gụnyere usoro mgbochi ịlọghachi, ugbu a; Nsonaazụ mbụ na-egosi nrụpụta nke usoro nchịkwa akparamaagwa akwara ji aka njikwa.37].

Otu ihe omumu banyere ntinye ihe di mkpirikpi nke akwukwo akwukwo (nke gunyere akparamagwa-akparamagwa na usoro iji bulie ya elu) ka atụnyere iji akwukwo akwukwo tinyere otu onye oru nyocha ogwu [38]. Otu abụọ a kwuru na mbelata dị egwu n'ịgba chaa chaa na ntinye nlere anya nke ọnwa 6. N'otu aka ahụ, akwụkwọ dị iche iche ekenyela ndị na-agba chaa chaa ka ha jiri akwụkwọ ọrụ, akwụkwọ akwụkwọ tinye mgbakwunye mgbakwunye ekwentị na-akpali, ma ọ bụ ndepụta echere. Tụnyere ndị na-eji akwụkwọ ọrụ naanị, ndị ịgba chaa chaa e nyere na ntinye mkpali tinyere akwụkwọ ọrụ belatara ịgba chaa chaa n'ime oge mmemme 2 niile.39].

Ọmụmụ ihe abụọ nwalekwara usoro ọgwụgwọ mkpocha azụ na enweghị nchekwube n'echiche echere. N'ime ọmụmụ ihe nke mbụ, ọgwụgwọ abụọ ahụ rụpụtara nkwalite n’ọbere obere ndị ọrịa [40]. N'ime ọmụmụ ihe nke abụọ, e kenyere ndị ịgba chaa chaa 120 pathologic na-enweghị usoro ọgwụgwọ mkpogharị, enweghị nchekasị, na vivo desensitization, ma ọ bụ izu ike. Ndị sonyere na-enweta atụmanya pụrụ ịkọpụtara nsonaazụ ka mma na ọnwa 1 na ruo na 9 afọ mgbe e mesịrị [41].

Trichotillomania

A kọwawo Trichotillomania dị ka ikwugharị, ntutu na-ama ụma na-eme ka ntutu na-ama ama ma na-ebute nhụjuanya dị ukwuu ma ọ bụ nrụrụ ọrụ [2]. A tụlere ebe ndị ọzọ na mbipụta a, trichotillomania yiri ka ọ bụ nke a na-ahụkarị, ebe enwere atụmatụ dị n'etiti 1% na 3% [42]. Afọ ole dị na mmalite maka trichotillomania bụ ihe dịka 13 afọ [43].

Omume moto ugboro ugboro nke ịdọpụ ntutu na njikwa dị nro na-enwe ọhụụ yiri nke OCD. N'ụzọ dị iche na OCD, nke mmanye na-eme n'ọtụtụ ọnọdụ, ndị nwere trichotillomania na-adọtakarị oge mgbe ha na-eme mmega ahụ [44]. Ọ bụ ezie na ntutu na-adọta na trichotillomania na-ebelata nchekasị, dị ka a na-amanye mmadụ na OCD, ọ nwekwara ike iwepụta obi ụtọ, ebe mmanye OCD anaghị eme ya.

A na-ahuta Trichotillomania dika nsogbu obula na-emetuta nwanyi.45] ma a na-ejikọkarị ya na ịda mbà n'obi (39% –65%), nsogbu nchegbu zuru oke (27% –32%), na iji ihe eme ihe (15% –20%). Karịsịa, ọnụego ihe jikọrọ OCD adịkarịsịrị elu (13% –27%) [43] karịa ka ahuru n’obodo (1% –3%) [46], na akụnụba a na-ewelite ohere nke ọghọm neurobiologic nkịtị na-akpata maka njikọta a hụrụ n'ọrịa abụọ a. Trichotillomania adịghị ejikọ ọnụego dị elu nke mgbaàmà ike-emetụta, yana otutu n'ogo na oke kwesịrị [44].

Ọnụego trichotillomania n'etiti ndị mmadụ nwere OCD ekwekọghị na nyocha niile. Ihe omumu ato nke obere ihe nlele nke isiokwu OCD egosiputala onu ahia sitere na 4.6% rue 7.1% [14,15,47]. Otu ihe omumu buru ibu banyere ndi 293 ndi nwere OCD akuko oge ndu ya na onu ogugu ugbua nke trichotillomania nke 1.4% na 1.0%, dika ndi ozo16]. Dị ka ọ dị na PG, ajụjụ ahụ ka na-enyocha ngalaba nke ịkakọ ihe n'ofe nsogbu ndị a, ọ ga-eme ka a mata ihe ọ ga-ekwe mee.

A na-akwado mmekọrịta dị n'etiti trichotillomania na OCD site na nchọpụta na OCD bụ ihe a na-ahụkarị na ndị ikwu nke nwere trichotillomania. Ọ bụ ezie na ọmụmụ akụkọ ihe mere eme ezinụlọ nke trichotillomania nwere ntakịrị, otu ọmụmụ na-atụ aro maka mmekọrịta ezinụlọ na OCD. Ọmụmụ ihe metụtara ndị 22 isiokwu ndị nwere trichotillomania na ndị ikwu nke ogo mbụ nke 102. Mgbe atụnyere otu ndị na-achịkwa (n = 33, ya na ndị ikwu 182 nke izizi), ndị ikwu dị omimi nke trichotillomania probands nwere OCD (2.9%) ma e jiri ya tụnyere ndị na-achịkwa [48]. Otu omumu ihe omumu nke OCD probands choputara oke onu ogugu n’ule karia ihe ndi mmadu nwere ike ime ya (t $ 60% na 4%)18].

Ọgwụ nke trichotillomania

Ọgwụ ọgwụgwọ lelere maka trichotillomania gụnyere ọgwụ na ọgwụ. Emebere ya nke ọma na usoro izizi nke ọgwụ ọgwụ maka OCD bụ SRI (dịka ọmụmaatụ, clomipramine, fluvoxamine, ma ọ bụ fluoxetine). Ihe omuma banyere uzo oma nke SRI maka trichotillomania enwechaghi nkwenye. Otu ọmụmụ jiri clomipramine na desipramine na usoro 10-izu abụọ kpuchiri ìsì, imebi ụzọ (izu 5 maka onye nnọchi anya ọ bụla mgbe izu 2 nke ụzọ onye isi kpuru ìsì) [49]. Iri na abụọ nke isiokwu 13 nwere nnukwu ọganihu mgbe ha na-anata Clomipramine. Ọ bụ ezie na SRIs dị mma maka OCD, ọgwụ ndị a egosipụtawo nsonaazụ ngwakọta na ule atọ na-enweghị atụ nke trichotillomania [50-52]. Na mgbakwunye, ndị nwere ọrịa trichotillomania na ndị nwere ọrịa SRI n'ụzọ gara nke ọma na-enwe oke nrịgharị nke mgbaàmà karịa ndị ọrịa SRI nwere OCD nwere.51].

Ndị ọrụ ọgwụ ọgwụ ndị ọzọ gosipụtara uru maka trichotillomania enwebeghị ike maka OCD. Enweghi ike oru a na-akpalite ajụjụ gbasara njikọta n'etiti nsogbu ndị a. Christenson na ndị ọrụ ibe [51] atụnyere opioid antagonist naltrexone na placebo na usoro 6-izu na-ezighi ezi, nke nwere okpukpu abụọ. Achọpụtara ọganihu dị ukwuu maka otu naltrexone n'otu ụzọ nke mgbaàmà trichotillomania. Na nyocha nke emeghe nke lithium, ihe 8 nke 10 na-akọ kọrọ mbelata na oge ndọta, oke ntutu dọtara, na oke ntutu isi [53] Lithium abaarala uru mgbe mgbe n'ịgwọ ndị nwere nsogbu ndị njigide mmụọ na-adịghị mma54]. Ezi ihe si na nnabata nke lithium [53] na-ebulite ohere ahụ nwere ike ịmị ihe kama ịmanye njimara na-anọchi anya ebumnuche ọgwụgwọ dị mkpa na ụfọdụ ndị trichotillomania. Inyocha nyocha nke hypothesis a tupu ekwenye ekwenye n'ihe a.

Ma OCD na trichotillomania na-aza ajụjụ banyere omume; agbanyeghị, ụdị omume omume ọgwụgwọ dị iche na iche nke ukwuu. Azrin na ndi oru ibe55] ndị 34 na-ekenye ha na-ezighi ezi na usoro ọgwụgwọ ịgbanwe omume ma ọ bụ omume na-adịghị mma (nke a gwara ha ka ha guzo n'ihu enyo ma gosipụta mmegharị nke ntutu ị na-adọkpụghị n’ezie. Habit weghachite ntutu ịdọrọ na-erughị ihe karịrị 90% maka ọnwa 4, ma e jiri ya belata 52% na 68% maka omume na-adịghị mma na ọnwa 3. Onweghi otu ìgwè na-achịkwa agụnyere, yabụ na oge a na-enyochaghị nlebara anya na usoro ọgwụgwọ.

Ọmụmụ nyocha emere n'oge na-adịbeghị anya nyochara ihe omume 25 na-agbagha izu izu 12 (oge 10) nke nnabata na ntinye ọgwụgwọ / nkwụghachi omume ma ọ bụ ndepụta nchere [56]. Isi ihe enyere aka na ọgwụgwọ ahụ nwere mbelata dị ukwuu na nrụgide ntutu na mmebi ma e jiri ya tụnyere ndị ekenyela na listi nchere ahụ, a na-emeziwanye ihe na 3-ọnwa.

Kleptomania

Akụkụ ndị bụ isi nke kleptomania gụnyere (1) ọdịda na-enweghị ike iguzogide mkpali nke izu ihe ndị na-adịghị mkpa; (2) echiche na-arịwanye elu nke esemokwu tupu ịme ohi ahụ; (3) ahụmịhe nke ihe ụtọ, afọ ojuju, ma ọ bụ mwepụta n'oge emere ohi; na (4) na-ezughi oke site na iwe, ịbọ ọbọ, ma ọ bụ n'ihi psychosis [2].

Dika OCD, kleptomania na - aputa ihe na izizi n’abia n’oge uto ma obu n’oge okenye.57]. Usoro ahụ na-abụkarị ala ala na -akpọ ma na-ebelata ihe mgbaàmà. N'adịghị ka OCD, Otú ọ dị, ụmụ nwanyị ji okpukpu abụọ karịa nke ụmụ nwoke na-ata ahụhụ site na kleptomania [57]. N'ime otu ọmụmụ, ndị niile sonyere kwuru na ha nwere ụba ume ohi mgbe ha na-achọ ịkwụsị izu ohi [57]. Ikike dị ntakịrị nke ịkwụsị ịkwụsị na-edugakarị na mmetụta nke ihere na obi amamikpe, nke ọtụtụ isiokwu na-ekwu (77.3%) [57].

N'agbanyeghị na ndị nwere kleptomania na-ezukarị ihe dị iche iche n'ọtụtụ ebe, ihe ka ọtụtụ na-ezuru n'ụlọ ahịa. N'otu nnyocha, 68.2% nke ndị ọrịa kọrọ na uru nke ihe ndị zuru ohi abaala ogologo oge [57]. Edere ọtụtụ (64% –87%) n'oge ụfọdụ n'ihi omume ha [58], na 15% gaa na 23% kọọ na a tụrụ ya mkpọrọ [57]. Ọ bụ ezie na ọtụtụ n'ime ndị ọrịa ahụ nwudatara kọrọ na agụụ ha nwere izu ohi belatara mgbe ụjọ jidere, mgbaghara mgbapụta ahụ na-adịgide naanị ụbọchị ole na ole ma ọ bụ izu ole na ole.58]. N'uzo, nchoputa ndi a gosiputara na ntinye aka na omume nsogbu agbanyeghi aka ojoo gi.

Omume ikwugharị a hụrụ na kleptomania bụ echiche nke mmanye, dị ka okwu ikpe nke mepere isiokwu a. Na mgbakwunye, ọtụtụ ndị nwere kleptomania (63%) na-agbanye ihe ụfọdụ dị na ha na-ezuru [57]. Nnyocha nyocha nke mmadụ nke ndị nwere kleptomania na-atụ aro na-egosi na ha na-ahụkarị maka mmụọ [59] na-akpali akpali [60] sikwa otú ahụ dị iche na ndị nwere OCD, ndị na-emerụkarị onye na-ezere nke nwere nsogbu dị egwu-ịchekwa omume ha [4]. N'adịghị ka ndị nwere OCD, ndị nwere kleptomania nwere ike ịkọ akụkọ ma ọ bụ nwee agụụ tupu ha etinye aka na izu ohi na oke hedonic n'oge arụ ọrụ nke izu ohi [7].

Achọpụtala ọnụọgụ nke ọrịa uche ndị ọzọ na ndị ọrịa nwere kleptomania. Ọnụego nsogbu ndị na - emetụta ndụ mmadụ na - esite na 59% [61] na 100% [58]. Mmụta achọtapụtakwala ogo ndụ ha niile nke nsogbu ụjọ ụjọ (60% ka 80%) [58,62] na nsogbu nke iji ihe eme ihe (23% ka 50%) [58,61].

Aghotaghi oke nke ihe omimi OCD na kleptomania. Ọnụ ego nke OCD na-emekọ ọnụ na ihe atụ nke mmadụ nwere kleptomania sitere na 6.5% [61] na 60% [63]. N'aka nke ọzọ, ọnụego kleptomania na nyocha OCD na-egosi ọnụego mmekọrịta dị elu karịa ka achọpụtara n'obodo (2.2% –5.9%) [14,15]. Ọmụmụ ihe ọmụmụ n'oge na-adịbeghị anya banyere ndị 293 ndị nwere OCD kọrọ akụkọ dị ugbu a na ndụ kleptomania (0.3% na 1.0%) [16] dị ala karịa ọnụego achọtara na ọnụnọ ọrịa ọrịa uche n'ozuzu ha (7.8% na 9.3%, otu isi) [64]. Nnukwu omumu ihe gbasara oria bu ihe puru iche nke kleptomania, ya mere na-egbochi ihe omuma banyere ihe omuma ya na uzo ihe ya na nsogbu ndi ozo di.

Ọmụmụ banyere akụkọ ezinụlọ na-atụnyere ndị mmadụ 31 ndị nwere kleptomania na 152 nke ndị ikwu mbụ ha nke nwere njikwa nchịkwa 35 na 118 nke ndị ikwu mbụ [61]. Ọmụmụ nyocha ahụ chọpụtara na 0.7% nke ndị ikwu nke kleptomania proband tara ahụhụ site na OCD ma e jiri ya tụnyere 0% n'ime ezinụlọ nke njikwa ahụ.

Ọgwụgwọ kleptomania

Naanị mkpesa ikpe, usoro ikpe abụọ, na otu nnyocha emepere emepe maka ọgwụ ọgwụ emeela maka kleptomania. Agụrụ ọgwụ dị iche iche n'ihe banyere akụkọ ma ọ bụ usoro ikpe, ma achọpụtakwala na ha dị mma: fluoxetine, northriptyline, trazodone, clonazepam, valproate, lithium, fluvoxamine, paroxetine, na topiramate [65]. N'adịghị ka ọgwụgwọ OCD, ọ dị ka nzaghachi preferenia nke kleptomania na ọgwụ serotonergic. Naanị nnwale ikpe ọgwụ maka kleptomania metụtara isiokwu 10 n'ime otu izu 12, nnabata ngosipụta nke naltrexone. N'ihe dị ka 150 mg / d, ọgwụ mere ka mbelata nke ukwuu na-eme ka izu ohi, echiche banyere izu ohi, na omume izu ohi [66].

Ọ bụ ezie na akọwaala ọtụtụ ụdị psychotherapies na ọgwụgwọ nke kleptomania, enweghị nnwale a na-achịkwa adịghị adị na akwụkwọ ahụ. Formzọ nke psychotherapy akọwapụtara na akụkọ mkpesa dịka igosipụta ihe ịga nke ọma gụnyere psychoanalytic, ọgụgụ isi, na usoro omume [58,67]. Ebe ọ bụ na ọ nweghị ọgwụ ọ bụla metụtara ọgwụgwọ maka kleptomania bipụtara, nrụpụta ọrụ nke ihe ndị a siri ike inwale, mana ụdị ọdịmma psychosocial, dịka ọ dị na ọgwụ ọgwụ, na-atụ aro na kleptomania dị n'ụdị heterogeneous.

Summary

Dịka a hụrụ n'usoro okwu mmeghe, ICDs ka akparamagwa akparamaagwa na mgbochi nke omume ndị a. Omume njiri ike njikwa nke ICD na-atụ aro yiri nke a na-eme ugboro ugboro, ememe na-adịghị mkpa, na-achọghị na OCD. Agbanyeghị, enwere ọdịiche dị n'etiti ICD na OCD (dịka, agụụ ma ọ bụ ọnọdụ agụụ ka achọpụtara na ICDs, ogo hedonic n'oge arụmọrụ nke omume ICD, na ụdị agwa na-achọkarị na ndị nwere ICD) [7]. N'agbanyeghị ọdịiche dị n'etiti ICD na OCD, a hụwo njirimara nke ịkpa ike na mkpakọrịta ndị metụtara ICD, na data mbido na-egosi na njirimara nke ịkwanye ugwu, yana ịkpa ike, nwere ike ịnọchite anya ebumnuche ọgwụgwọ dị mkpa na ụfọdụ ICD.

Atụmatụ n'ọdịnihu

N'ihi na nyocha pere mpe, yana nchọpụta dịgasị iche, ọ dị ka ịkpụchapu afọ iji mata ndị ICD na OCD. A ka ga-enyochakwu etu enwere ICD ma ọ bụ ụdị dị iche iche nke ICD nwere njikọ chiri anya OCD n'usoro. Na mgbakwunye, iwu nke ịkakọta dị ka nke metụtara ICD na OCD na-enyekwu nyocha ọzọ iji chọpụta myirịta na ọdịiche na inyocha ihe ọ pụtara maka usoro mgbochi na usoro ọgwụgwọ. Dịka ọmụmaatụ, nyere na ọgwụgwọ nke ICDs na SRIs gosipụtara nsonaazụ agwakọta, a chọrọ nyocha ndị ga-eme n'ọdịnihu iji chọpụta ma otu ìgwè dị iche iche (dịka, ndị nwere PG nwere njirimara ụfọdụ nke mgbakwunye ma ọ bụ mkparị) na-anabata nke ọma ma ọ bụ njọ na ọgwụgwọ ndị akọwapụtara (wdg., SRI). N'otu aka ahụ, akụkụ akpọrọ akpọrọ iche nwere ike ịnọchite anya ebumnuche maka nsogbu maka omume maka ICD. Ọmụmụ ihe ọmụmụ biologic n'ọdịnihu nke ICD (dịka, mkpụrụ ndụ ihe nketa, neuroimaging) kwesịkwara ịgụnye usoro nke ịgbakọ iji ghọta n'ụzọ dị mma na nkwarụ OC dị.

Ihe odide ala

Enyemaka a sitere na Institutelọ Ọrụ Mba Ahụike Ahụike (K23 MH069754-01A1) kwadoro ọrụ ahụ.

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