Behav Brain Res. 2016 May 6. pii: S0166-4328(16)30276-5. doi: 10.1016/j.bbr.2016.05.010.
Liu C1, Wang J2, Zhan B1, Cheng G1.
nkịtị
Ọ bụ ezie na ụgwọ ọrụ ọgwụ na ụgwọ ọrụ sitere n'okike na-ekerịta ihe ndị na-eme ka akwara ozi, usoro na usoro mmalite nke neuronal na-akpata mmekọrịta dị n'etiti cocaine na ụgwọ ọrụ ọha na eze aghọtachaghị nke ọma. N'ebe a, anyị na-enyocha mmasị ọnọdụ ọnọdụ (CPP) na mmekọrịta mmadụ na ibe ya (kpọmkwem) vs cocaine conditioning, na okwu nke Central c-Fos, oxytocin (OT) na vasopressin (AVP) na ụmụ oke ICR nwere ọnọdụ. Anyị chọpụtara na ụmụ oke ndị ahụ na-emepụta CPP mgbe ejiri ya na-amaghị ama ma ọ bụ cocaine naanị.
Otú ọ dị, ụmụ oke ndị ahụ emepụtaghị CPP mgbe ihe mkpali abụọ ahụ nwere otu ọnọdụ. E jiri ya tụnyere ịkwado ya na naanị ya, ụmụ oke belatara mmasị maka nkọwapụta mgbe ha na-emekọrịta ihe na mmekọrịta mmadụ na ibe ya vs cocaine. Anyị hụrụ ngosipụta dị iche iche nke c-Fos-immunoreactive neurons na ventral anterior cingulate cortex, posterior cingulate cortex, accumbens (shell na isi), etiti etiti nke amygdale na ventral pallidum mgbe atụnyere njikwa (CK), social (SC) ma ọ bụ cocain conditioning (CC) otu, na social vs cocaine conditioning (SCC). E jiri ya tụnyere otu CK, otu SC ma ọ bụ CC nwere okwu OT dị elu na oghere paraventricular (PVN) na okwu AVP dị ala na PVN na supraoptic nucleus. Otu SCC gosipụtara okwu OT dị ala ma e jiri ya tụnyere otu SC, yana okwu OT na AVP dị elu na PVN ma e jiri ya tụnyere otu CC.
Nsonaazụ ndị a na-egosi na cocaine na-emebi mmasị ọha mmadụ site na asọmpi na ụgwọ ọrụ ọha. Ọrụ dị iche iche nke neurons n'ime mpaghara ụgwọ ọrụ a kapịrị ọnụ, na okwu dị iche iche nke OT na AVP nwere ike ịrụ ọrụ dị mkpa n'ịgbazi mmekọrịta n'etiti ụgwọ ọrụ mmekọrịta mmadụ na cocaine.
AKWỤKWỌ:
Cocaine; Mmasị ọnọdụ ọnọdụ; Neuropeptide; Ụgwọ ọrụ
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