Eur Neuropsychopharmacol. 2015 Oct 9. kpọọ: S0924-977X (15) 00310-7. ma ọ bụ: 10.1016 / j.euroneuro.2015.09.015.
Georgiou P1, Zanos P1, Garcia-Carmona JA2, Hourani S1, Usekwu I1, Kieffer BL3, Mbụ Mord2, Bailey A4.
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Relaghachi azụ n'ịchọ ọgwụ n'ụzọ na-ezighi ezi bụ nnukwu ihe ịma aka maka ọgwụgwọ nke ọgwụ riri ahụ ebe ọ nweghị ọgwụ ọgwụ dị irè dị. Anyị gosipụtara n'oge na-adịbeghị anya na ịgbalite sistemụ akwara oxygen na-egbochi mwepu mmetụta uche na iweghachite mgbali nrụgide metụtara opupu opioid. N'ebe a, anyị nyochara ma carbontocin analogue carbetocin (CBT) nwere ike iweghachite morphine-primed iweghachi nke ọnọdụ nwere ọnọdụ (CPP) na ụmụ oke.
E nyochara usoro nke na-egosipụta mmetụta omume CBT site na ịtụle ntinye aka nke sistemu noradrenergic na usoro dopaminergic na CBT na-atụgharịghachi nke priming- na nrụgide nrụgide nke opioid CPP. Na mgbakwunye, enyere aka na nso nso a na-egosi na ọnụnọ nke oxygentocin receptor (OTR) -μ-opioid receptor (MOPr) na ụbụrụ, anyị nyochara mmekọrịta ndị a ọzọ site na ịme OTR autoradiographic ejikọ ya na ụbụrụ nke ụmụ oke nwere MOPr.
Nlekọta CBT gbochiri iweghachite morphine CPP iji bute mmalite ya. Ka enwere mmetụta CBT dị ukwuu n'ịkwalite ntụgharị ọgwụ dopamine mgbe nrụgide-na iweghachigharị mkpali, CBT gbadata ntụgharị noradrenaline naanị na-esote iweghachi ikike ịmalite. Ọzọkwa, nnukwu ụbụrụ mpaghara dị mkpa na - ejikọtara ọnụ maka OTR na ụmụ oke MOPr, na-egosi ọnụnọ nke OTR-MOPr nwere ike ịmekọrịta, nke nwere ike itinye aka na mgbanwe mgbanwe nlọghachi.
Nsonaazụ ndị a na-akwado sistemụ oxytocinergic dị ka ebumnuche na-ekwe nkwa maka igbochi nlọghachi azụ na iji opioid ma gosipụta ọdịiche dị iche iche nke usoro monoaminergic na nsonaazụ nke mkpali OTR iji gbochie nrụgide-na iweghachite iweghachi omume opioid CPP.
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