Ihu ihu. Behav. Neurosci. | doi: 10.3389 / fnbeh.2016.00154
Paula Banca1*, Valerie Voon2, 3 na Neil A. Harrison4
- 1Ọzụzụ na Clinical Neuroscience Institute, Mahadum nke Cambridge, United Kingdom
- 2Ngalaba isi mgbaka, Mahadum nke Cambridge, United Kingdom
- 3Cambridgeshire na Peterborough NHS Foundation Trust, United Kingdom
- 4Brighton na Sussex Medical School, Mahadum nke Sussex, United Kingdom
Mmeghari akparamagwa a choro maka mmeghari nke oma na gburugburu na agbanwe agbanwe. A na-ahụkarị nkwarụ mgbanwe mgbanwe omume na nsogbu ọrịa uche gụnyere ndị riri ahụ. Ọmụmụ ihe a na-enyocha akụkụ abụọ nke ịkpa ike, ya bụ, mmụta azụmaahịa na nlebara anya na-agbanwe, na-emetụta orbitofrontal na akụkụ prefrontal n'otu n'otu, gafee nsogbu nke ụgwọ ọrụ nke mbụ na nke abụọ. Ejiri usoro ịeseụbiga mmanya oke (BED), ndị nwere omume agụụ mmekọahụ (CSB), nsogbu ị alcoholụ mmanya na-egbu egbu (AUD) na egwuregwu vidiyo (VG) jiri ọrụ kọmputa abụọ lelee: Probabilistic Reversal Task (ọnwụnwa ruo nkwupụta na njehie ọnụnọ / ọdịda mmachi) na intra / Extra-ዘር Set Setft Shift (IED). Ndị nwere AUD na egwuregwu vidiyo egwuregwu ji nwayọ nwayọ na iweghachite mmụta na-agbanyeghị obi ọjọọ, na ndị AUD nwere ike ịnọgidesi ike mgbe mmesịrị. E jiri ya tụnyere isiokwu buru ibu na-enweghị BED, isiokwu BED dị njọ na ngbanwe mmụta iji nweta mmeri mana ọ ka mma maka mmefu na-egosi mmetụta ọjọọ dị ka ọrụ nke iri nri riri ọnụ. Ihe omume CSB gosipụtara inwekwu uche iji rụpụta nsonaazụ site na inweta ngwa ngwa na ntachi obi ka ukwuu na-akwụghachi ụgwọ dị ukwuu. Anyị na-egosi n’ihu na-ezughị ike na setịpụrụ na-agbanwegharị n'ime ndị mmadụ nwere BED na AUD nke ndị ọrụ afọ ofufo mara mma. Ọmụmụ ihe a na-enye ihe akaebe maka ọdịiche na ọdịiche abụọ dị iche iche nke mgbanwe omume na-agafe n'ofe nsogbu nke mgbako. Ọmụmụ ihe a na-enye ihe akaebe maka ọdịiche na ọdịiche abụọ dị iche iche nke mgbanwe omume na-agafe n'ofe nsogbu nke mgbako. Anyị na-achịkọta ọmụmụ banyere ụdị ihe dị iche iche dị n'otu ọgụgụ ndị ọrịa a. Anyi n’eme ka ihe ndi ozo di na AUD na BED na mmebi ha gabiga otutu ihe ngosi, ma eleghi anya na-akwado iri nri dika ihe mmasi. Anyị na-aga n’ihu ime ka ihe ndị a na-ahụkarị anya n’ịzụgharị mmụta gafee nsogbu na ọrụ dị mkpa nke mmetụta valence. Nchọpụta ndị a na-egosipụta ọrụ nke mgbanwe mgbanwe omume na ịkọwa okwu dị ka ngalaba dị mkpa na ịkọwapụta ụdị echiche ọgụgụ isi na njirimara endophenotypes dị mkpa dị ka ebumnuche maka mgbanwe ọgwụgwọ.
Keywords: Mmanya riri nne, mmanya na-egbu egbu, Nsogbu iri nri nke Binge, mkpakọ, mmụta mmụta, Ntọgharị.
Akwụkwọ akụkọ: Banca P, Voon V na Harrison NA (2016). Mgbako n'ofe nje na-a rewardsụ ọgwụ na ụgwọ ọrụ na-abụghị ọgwụ. N'ihu. Behav. Neurosci. 10: 154. a: 10.3389 / fnbeh.2016.00154
Enwetara: 14 Apr 2016; Anakwere: 19 Jul 2016.
Nhazi: Matthias ika, Mahadum Duisburg, Germany
Enyocha site:
Alicia Izquierdo, Mahadum California, Los Angeles, USA
Juan M. Dominguez, Mahadum Texas na Austin, USA
Rudolf Stark, Mahadum nke Giessen, Germany
* Akwụkwọ ozi: Dr. Paula Banca, Mahadum nke Cambridge, Behavioral na Clinical Neuroscience Institute, Cambridge, United Kingdom, [email protected]
ABSTRACT
CSB na-achị gosipụtara uche ziri ezi iji rụpụta nsonaazụ ngwa ngwa inweta ngwa ngwa na ntachi obi ka ukwuu na ụgwọ ọrụ dị ukwuu.
IHE
Ilszọ nke nkatọ: Na oge ngbanwe na isiokwu CSB (N = 25) ma e jiri ya tụnyere ndị ọrụ afọ ofufo nwere ahụike (N = 50) enweghị isi ọrụ nke Group (F (1,73) = 1.33, p = 0.253), Valence (F (1,73) = 1.47, p = 0.229) ma ọ bụ mmetụta mmekọrịta (F (1,73) = 0.008, p = 0.928) (ọgụgụ 1). N'ime oge nnweta na CSB isiokwu (wardkwụ :gwọ: HV 9.39 (SD 7.34); CSB 6.39 (SD 5.43); Loss: HV 7.26 (SD 6.53); CSB 8.69 (SD 7.83)) enwere mkparịta ụka x Valence esemokwu (F (1,73) = 4.35, p = 0.039) nke ndị CSB nwere ngwa ngwa mụta ihe site na wardsgwọ Ọrụ na nwayọ iji mụta ihe site na Mfu ma e jiri ya tụnyere ndị ọrụ afọ ofufo ahụike. Enweghị otu (F (1,73) = 0.38, p = 0.539) ma ọ bụ mmetụta Valence (F (1,73) <0.001, p = 0.983 Win-Stay / Lose-Shift: Na nyocha Lose-Shift, n'ebe ahụ bụ mmetụta nke otu x Valence (Ntọala 3; Nyocha 2); na nyocha nke posthoc, isiokwu CSB nwere obere Lose-Shift ma ọ bụ yikarịrị ka ọ ga-anọ ma ọ bụ nọgidesie ike mgbe ọ nwụsịrị na ọnọdụ nkwụghachi ụgwọ 422 ka Loss (p = 0.005) na Neutral (p <0.001). N'otu aka ahụ, na nyocha nke Win-Stay, enwere mmetụta otu x Valence; na nyocha posthoc, CSB nwere mmeri dị elu ma ọ bụ nwee ike ịnọdụ mgbe mmeri meriri n'ọnọdụ wardgwọ Ọrụ metụtara Loss (p = 0.019) na Neutral (p = 0.007). 427
Na nchikota: Ihe omume CSB di ngwa ngwa ka mmuta site na ugwo ya na ngalaba inweta ma e jiri ya tụnyere ndi enyem aka nke oma ma nwekwaa ike ntachi obi ma obu nọrọ n’otu mgbe ihe nwuru ma obu mmeri n’onodu ugwo.
NKWASỊTA
Akwụkwọ a na-egosipụtakarị akụkụ dị iche iche nke sekọndị ihu ihu ihu na ndọghachi azụ na ntinye uche, nke bụ orbitofrontal na mpụta prefrontalcortices n'otu n'otu. Anyị ebuola ụzọ banyere usoro ndị a maka mmụta nlọghachị (ọnụọgụ ọnwụnwa gaa na nkatọ) na ngbanwe nke ED na-egosi mmekọrịta n'etiti sekit ndị dị n'ihu (Morris et al., 2016).
N’adịghị ka nsogbu ndị ọzọ, CSB atụnyere ndị ọrụ afọ ofufo nwere ahụ ike gosipụtara nnweta ngwa ngwa maka nsonaazụ nsonaazụ ya na ntachi obi ka ukwuu na ọnọdụ ụgwọ ọrụ n'agbanyeghị ihe ga-esi na ya pụta. Ihe omume CSB egosighi mmebi ọ bụla akọwapụtara na usoro ịdegharịgharị ma ọ bụ mgbanwe mmụta. Ihe nchoputa a metụtara ihe anyi choro na nkwalite ochicho nke nkwalitesi ike na nmekorita nke nwoke ma obu ego, n’enye atumatu aka di elu banyere ugwo (Banca et al., 2016). Emere ihe omumu ozo site na iji ugwo di nma. A kọbeghị ntụpọ nke omume ebumnuche ebumnuche ma ọ bụ nyocha na CSB.
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