EKPERE: Ọmụmụ banyere ihe gbasara ịba uru (porn / mmekọahụ riri) na-akọ na mgbanwe epigenetic na-egosipụta ndị na-a inụbiga mmanya ókè. Mgbanwe nke epigenetic mere na mkpụrụ ndụ ihe nketa nke metụtara usoro oxygentocin (nke dị mkpa na ịhụnanya, njikọkọ, ihe mgbakwunye, nrụgide, wdg). Isi ihe:
- Mmekọahụ nke epigenetic nke mmekọahụ / porn riri ahụ maka sistemụ ikuku oxytocin yiri ndị aholicụrụma
- Ihe nchoputa nke ihe omumu kwekọrọ Kuhn & Gallinat, 2014 (ihe omumu ihe omumu nke fMRI na ndi oru porn)
- Nchọpụta nwere ike igosipụta sistemụ nrụrụ dysfunctional (nke bụ mgbanwe dị mkpa na iri mmadụ ahụ)
- Mgbanwe na mkpụrụ ndụ mkpụrụ ndụ oxytocin nwere ike imetụta njikọta, nrụgide, ọrụ mmekọahụ, wdg.
Maka inweta ihe ozo, guo edemede a kama nka: Ndị ọkà mmụta sayensị na-achọpụta homonụ nwere ike inwe nsogbu hyperexual
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Adrian E. Boström, Andreas Chatzittofis, Diana-Maria Ciuculete, John N. Flanagan, Regina Krattinger, Marcus Bandstein, Jessica Mwinyi, Gerd A. Kullak-Ublick, Katarina Görts Öberg, Stefan Arver, Helgi B. Schiöth & Jussi Jokinen (2019) )
Epigenetics, DOI: https://doi.org/10.1080/15592294.2019.1656157
nkịtị
A tụpụtara hyperexual aghara (HD) ka ọ bụrụ nchoputa na DSM-5 na kọwapụtara 'Compulsive Sexual Behavio Disorder' ugbu a ka ọ bụrụ ọgba aghara nchịkwa na ICD-11. HD tinye ọtụtụ usoro pathophysiological; gụnyere agụụ mmekọahụ, agụụ mmekọahụ, agụụ mmekọahụ na iri mmadụ riri ahụ. Onweghi ihe omumu nyocha gara aga nyocha HD na nyocha nke oke na microRNA (miRNA) saịtị CpG metụtara. A tụrụ ụkpụrụ ụdị methylation genome na ọbara dum site na isiokwu 60 nwere HD na 33 ndị ọrụ afọ ofufo ahụike na-eji Illumina EPIC BeadChip. E nyochara ihe ntanetị CpG-8,852 na nyocha nyocha nke methylation M-ụkpụrụ ka ọnụọgụ abụọ nọọrọ onwe ya na steeti ọrịa (HD ma ọ bụ ndị ọrụ afọ ofufo dị mma), na-agbazi maka covariates kpebisiri ike. A nyochachara ọkwa nhọpụta miRNAs nke onye ọchọpụtara n'ime otu ndị ahụ maka nyocha okwu ngosi dị iche. A gara n’ihu ịmụba onye na-eme ihe gbasara mmụba maka njikọta na ị alcoholụbiga mmanya ókè na ndị otu nọọrọ onwe ha nke ihe ọmụmụ 107. Abụọ CpG-saịtị ndị gbara ama ama dị na HD - cg18222192 (MIR708) (p <10E-05,pFDR = 5.81E-02) na cg01299774 (MIR4456) (p <10E-06, pFDR = 5.81E-02). MIR4456 gosipụtara nke ọma nke ọma na HD na nyocha abụọ (p <0.0001) na multivariate (p <0.05). Ejikọtara usoro Cg01299774 methylation n'ụzọ dị iche na ọkwa MIR4456 (p <0.01) ma methylated dị iche na mmanya na-aba n'anya (p = 0.026). Gene iche amụma na ụzọ nyocha gosipụtara na MIR4456 na-elekwasị anya na mkpụrụ ndụ ihe nketa na-egosi nke ọma na ụbụrụ na nke ahụ na-etinye aka na usoro mkpụrụ ndụ ihe omimi ndị chere na ọ dị mkpa maka HD, dịka, ụzọ mgbapụ nke oxytocin. Na nchịkọta, ọmụmụ ihe anyị na-egosi na MIR4456 nwere ike inye aka na pathophysiology nke HD site na-emetụta mmetụta nke oxytocin.
SITE NA NTA
Na nyocha njikọta methylation DNA na ọbara mgbatị, anyị na-achọpụta CpG-saịtị dịgasị iche jikọtara na MIR708 na MIR4456 nke dịkarịsịrị iche na ndị ọrịa HD. Na mgbakwunye, anyị gosipụtara na hsamiR- 4456 metụtara methylation locus cg01299774 dị iche na methylated na ịdabere na mmanya, na-atụ aro na ọ nwere ike ịbụ nke metụtara na ihe riri ahụ nke a hụrụ na HD.
Iji mara anyị, ọ nweghị akwụkwọ ọ bụla gara aga kọwara MIR4456 na mpaghara nke psychopathologies. Anyị na-achọpụta na miRNA a bụ nke chebere evolushọn n'ihe gbasara usoro mebere usoro na usoro isi mmalite ntutu isi site na mmalite nke primates. Na mgbakwunye, anyị na-enye ihe akaebe na ebumnuche mRNA nke MIR4456 bụ nke akọwapụtara na amygdala na hippocampus, mpaghara ụbụrụ abụọ nke Kühn et al na-atụ aro. ka ekpughere ya na oria pathophysiology nke HD [5].
Ntinye aka na uzo ihe mmuputa anakpoputara nke akowara na ihe omumu a putara ihe emere ka otutu ihe akowara HD dika nke Kafka et al. [1], dika agụụ agụụ mmekọahụ, agụụ mmekọahụ, ihe mkparị na (mmekọahụ) riri ahụ. Isi ihe nke hypothalamus nke mepụtara hypothalamus mepụtara hiri nne na nke etinyere site n'aka nke ọkpụrụkpụ pituitary, oxytocin na-arụ ọrụ dị mkpa na njikọta mmekọrịta na inwe mmekọahụ na ụmụ nwoke na ụmụ nwanyị [59]. Murphy et al. kọwara ọkwa dị elu n'oge agụụ mmekọahụ [60]. Burri et al. Achọpụtara na ngwa introasal oxygentocin n'ime ụmụ nwoke rụpụtara mmụba nke ọkwa plasma nke epinephrine n'oge omume mmekọahụ na mgbanwe gbanwere banyere mmụọ [61]. Ọzọkwa, a na-atụ aro maka oxygentocin iji gbochie ọrụ nke hypothalamic-pituitary-adrenal (HPA) n'oge nrụgide. Jurek et al. chọpụtara na sistemụ ikuku oxygentocin na-ebugharị ntughari nke corticotropin na-ewepụta ihe (Crf) na ngalaba paraventricular nucleus, ihe ọmụmụ nke nwere njikọ siri ike na nzaghachi nrụgide [62].
Mgbanwe na ụzọ mgbapụ oxytocin nwere ike ịkọwa ihe nchoputa nke Chatzittofis et al., Onye hụrụ HPA axis dysregulation n'ime ụmụ nwoke nwere nsogbu hypersexual [3]. Ọzọkwa, ọmụmụ na-egosi na oxytocin nwere ike itinye aka na pathophysiology nke obsessive-mmanye aghara aghara [63]. Mkparịta ụka nke oxytocin na usoro dopamine, HPA-axis na usoro ahụ ji alụso ọrịa ọgụ dugara na postulation na esemokwu ndị mmadụ n'otu n'otu na ọkwa oxygentocin na-emetụta mmerụ ahụ riri ahụ [64]. Ọ bụ ezie na oxytocin na mbụ ejikọtara na nhazi nke mmekorita nke mmekọrịta mmadụ na ibe ya, Johansson et al. gosikwara na mgbanwe mkpụrụ ndụ ihe nketa na mkpụrụ ndụ oxygentocin receptor gene (OXTR) metụtara mmetụta nke imeghachi ọnọdụ n'ọnọdụ oke iwe dị n'okpuru mmetụta nke mmanya [65]. N'ikpeazụ, Brüne et al. kwubiri na mgbanwe mkpụrụ ndụ ihe nketa na OXTR nwere ike itinye aka na ịkọwa ọrịa pathophysiology nke nsogbu ịkpa oke ókè [66], ihe gbasara akparamagwa nke e ji mara ịkpa ike dysregulation [66].
MIR4456may nwere ọrụ nchịkwa ọzọ na HD nke egosighi na ọmụmụ ugbu a. N'ikwekọ na nchoputa anyị, ọmụmụ ndị gara aga kọọrọ mkpakọrịta nke omume mmekọahụ nwoke na-adịghị ike na mkpụrụ ndụ ihe nketa nke na-etinye aka na usoro glutamatergic na ndị mmadụ nwere nkụda mmụọ [67]. Ọzọkwa, enwere ike ọrụ nke 3ʹ-5ʹ-cyclic adenosine mono phosphate (cAMP) na nnabata mmekọahụ na oke oke nwanyị, site na ịgbanwere phosphoprotein-32 ma na-eduga na mgbanwe nke ndị na-anabata ndị nnabata [68]. N'ụzọ na-akpali mmasị, cAMP na-ahazikwa ụmụ irighiri ihe metụtara ntụzịaka axon [69], dị ka usoro B3gnt1, nke e jikọtara ya na omume mmekọahụ arụrụ ọrụ na ụmụ oke.
NKWUP FIRSTTA NKE MBOUT:
Ndị ọkà mmụta sayensị na-achọpụta homonụ nwere ike inwe nsogbu hyperexual
Nnyocha ọhụrụ nke ụmụ nwoke na ụmụ nwanyị nwere ọrịa hyperexual kpughere ọrụ nwere ike ịba uru na oxygentocin, dịka nsonaazụ ndị e bipụtara na akwụkwọ akụkọ ahụ. Epigenetics. Nchọpụta ahụ nwere ike imepe ụzọ iji gwọọ nsogbu ahụ site na injinịa ụzọ iji gbochie ọrụ ya.
A na-ahụta nsogbu hypersexual, ma ọ bụ inwe mmekọahụ na-akpali agụụ mmekọahụ dị ka nsogbu mmekọahụ metụtara ike, nke edepụtara listedtù Ahụ Ike disorderwa. Enwere ike ịkọwa ya site na -echekarị echiche gbasara mmekọahụ, manye mmadụ ka ya na-enwe mmekọahụ, ma ọ bụ nwee njide onwe ya, ma ọ bụ omume mmekọahụ nwere ike ibute nsogbu ma ọ bụ ihe egwu. Ọ bụ ezie na atụmatụ dị iche iche dịgasị iche iche, akwụkwọ na-egosi na ọgba aghara hyperexual na-emetụta 3-6% nke ndị bi.
Esemokwu gbara ya gburugburu maka ịchọpụta ihe n'ihi na ọ na-abụkarị n'akụkụ okwu ahụike ndị ọzọ, na-atụ aro na ọ ga-abụ ndọtị ma ọ bụ ngosipụta nke nsogbu uche dị adị. A maghị ihe dị ukwuu banyere neurobiology dị n'azụ ya.
"Anyị wepụtara iji nyochaa usoro usoro nchịkwa nke epigenetic n'azụ nsogbu mmekọahụ rụrụ arụ ka anyị wee nwee ike ịchọpụta ma ọ nwere akara ngosi ọ bụla nke mere ka ọ dị iche na nsogbu ahụike ndị ọzọ," ka onye edemede bụ Adrian Boström si na Ngalaba Neuroscience na Mahadum Uppsala, Sweden onye duziri ọmụmụ ihe na ndị nyocha si Andrology / Sexual Medicine Group (ANOVA) na Karolinska Institutet, Stockholm, Sweden.
"N'ihe anyị maara, ọmụmụ ihe anyị bụ nke mbụ na-emetụta usoro epigenetic dysregulated nke DNA methylation na microRNA ọrụ na ntinye nke oxytocin na ụbụrụ n'etiti ndị ọrịa na-achọ ọgwụgwọ maka mmekọahụ."
Ndị ọkà mmụta sayensị ahụ tụtara usoro methylation DNA na ọbara site n'aka ndị ọrịa 60 nwere nsogbu hypersexual ma jiri ha tụnyere ndị nlele sitere na ndị ọrụ afọ ofufo nke 33.
Ha nyochara mpaghara 8,852 nke DNA methylation metụtara microRNAs dị nso iji chọpụta ọdịiche ọ bụla n'etiti sample. DNA methylation nwere ike imetụta nkwupụta mkpụrụ ndụ na ọrụ nke mkpụrụ ndụ ihe nketa, na-eme ihe iji belata ọrụ ha. N'ebe achọpụtara mgbanwe na methylation DNA, ndị nchọpụta nyochara ọkwa nke usoro nkwupụta nke microRNA metụtara. MicroRNA bụ ihe na-atọ ụtọ dịka ha nwere ike ịgafe ihe mgbochi ụbụrụ-ọbara ma gbanwee ma ọ bụ mebie ngosipụta nke ihe ruru narị narị mkpụrụ ndụ dị iche iche na ụbụrụ na akwara ndị ọzọ.
Ha tụlere ihe nchoputa ha n’omume sitere n’isi 107, 24 n’ime ha bụ ndị mmanya na-egbu, iji nyochaa mkpakọrịta na agwa ndị na-eri ahụ.
Nsonaazụ gosipụtara mpaghara abụọ nke DNA nke gbanwere na ndị ọrịa ọrịa hyperexual. Agwaghasị ọrụ ọrụ methylation DNA ahụ wee mebie microRNA metụtara, itinye aka na ịgbachi mkpụrụ ebe a chọpụtara na-ekwenyeghị ihe ọ bụla. Nnyocha mere kpughere na microRNA ahụrụ, microRNA-4456, na-elegara mkpụrụ ndụ ihe nketa ndị a na-egosipụtakarị na ọkwa dị elu na ụbụrụ yana ndị na-etinye aka na nhazi nke hormonetoto. Site na ịgbachi nkịtị site na ịgbachi nkịtị, enwere ike ịtụ anya oxytocin na ọkwa dị elu, ọ bụ ezie na ọmụmụ ugbu a anaghị egosi nke a.
Achọpụtala ya n'ụdị vood na otu ụdị mkpụrụ ndụ neurotoptide oxytocin na-arụ ọrụ dị mkpa na usoro nke njikọ mmekọrịta. Omumu ihe omumu gara aga egosiputala na o nwere ihe jikọrọ oxytocin na mmekorita nke mmekorita nke nwoke na nwanyi, mmekorita nwoke na nwanyi na mmeko nwoke na nwanyi. Tụnyere ihe ndị metụtara ị alcoholụbiga mmanya ókè kpughere otu mpaghara DNA ahụ ka ọ bụrụ nke a na-ahụkarị, na-atụ aro na ọ nwere ike bụrụ nke metụtara na ihe ndị na-eri ahụ nke ọgba aghara, dị ka iri mmadụ agụụ mmekọahụ, agụụ mmekọahụ dysregulated, agụụ mmekọahụ na agụụ mmekọahụ.
Prọfesọ Jussi Jokinen si Umeå na-ekwu, sị: "A ga-achọ nyocha ọzọ iji nyochaa ọrụ nke microRNA-4456 na oxytocin na nsogbu mmekọrịta nwoke na nwanyị, ma nsonaazụ anyị na-egosi na ọ ga-abụ ihe bara uru iji nyochaa uru nke ọgwụ na psychotherapy iji belata ọrụ nke oxytocin." Mahadum, Sweden.
Ndị ode akwụkwọ ahụ kwuru na mmachi ọmụmụ ihe ahụ bụ na ọdịiche pụtara na DNA methylation n'etiti ndị ọrịa ọrịa hypersexual na ndị ọrụ afọ ofufo nwere ahụ ike bụ naanị ihe dị ka 2.6%, yabụ enwere ike ịkpọ mmetụta na mgbanwe mgbanwe anụ ahụ na ajụjụ. Agbanyeghị, akụkụ ihe akaebe na-eto eto na-atụ aro na naanị mgbanwe methylation nwere ike ịnwe nsonaazụ buru ibu maka ọnọdụ ndị siri ike dịka ịda mbà n'obi ma ọ bụ schizophrenia.
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A kwadoro ego omumu ihe a site na nkwekorita mpaghara nke Mahadum Umeå na Västerbotten County (ALF) na enyemaka nke Stockholm County Council na Sweden Research Foundation, Åhlens Foundation, Novo Nordisk Foundation, na Swedish Brain Research nke Sweden. Ntọala.
NKE AKW ABKWỌ NKE AB ABỌ:
Mgbanwe Epigenetic jikọtara ya na ọgba aghara Hypersexual na omume riri ahụ
MedicalResearch.com Ajụjụ ọnụ: Adrian E. Boström MD, n'aha ndị dere ya
Ngalaba Neuroscience, Mahadum Uppsala, Sweden
MedicalResearch.com: Gini bu ihe omumu a?
Azịza: Ọ bụ ezie na atụmatụ dị iche iche dịgasị iche iche, akwụkwọ na-egosi na hyperexual aghara (HD) na-emetụta 3-6% nke ndị bi. Agbanyeghị, arụmụka gbara ya gburugburu gbasara nchọpụta ahụ, amachaghịkwa banyere ọrịa neurobiology dị n'azụ ya.
Enyochabeghị nsogbu mmekọahụ rụrụ arụ na mbụ banyere epigenomic na transcriptomics na usoro ọmụmụ na-enweghị echiche na-enweghị ihe ọ bụla ma amachaghị banyere neurobiology n'azụ nsogbu a. Anyị nyochara ma enwere epigenetic mgbanwe ọ bụla na-emetụta ọrụ mkpụrụ ndụ na nkwupụta na ọrịa ndị mmekọ nwoke na nwanyị (HD) ma chọpụta microRNA dysregulated nke ekwenyere na ọ ga-emetụta usoro nke ihe nke hormone oxytocin na ụbụrụ.
Oxytocin maara na ọ nwere mmetụta omume dịgasị iche iche. N'ihe kachasị anyị maara, ọ nweghị ọmụmụ gara aga nyere ihe akaebe maka njikọ dị n'etiti methylation DNA, ọrụ microRNA na oxytocin na nsogbu mmekọrịta nwoke na nwanyị. Nchọpụta anyị kwesịrị nyocha ọzọ na ọrụ nke MIR4456 na karịsịa Oxytocin na nsogbu mmekọrịta nwoke na nwanyị. A chọkwuru ọmụmụ ihe iji gosi ọrụ nke Oxytocin na HD na iji chọpụta ma ọgwụgwọ na ọgwụgwọ ọgwụ na-eme ka ndị na-eme ihe ike nwere ike inwe mmetụta bara uru maka ndị ọrịa na-arịa ọrịa mmekọahụ rụrụ arụ.
MedicalResearch.com: Kedu ihe bụ isi nchoputa?
Azịza: - N'ime ọmụmụ a, anyị nyochara ihe karịrị 8000 dị iche iche methylation DNA nke ejiri usoro hypothesis na-enweghị ya, na-enweghị isi. Ya mere, anyị nwere ihe ijuanya ma nwee ihe ịtụnanya ịchọpụta mkpụrụ ndụ ihe nkedo microRNA siri ike gbadoro ụkwụ nke e gosipụtara na ụbụrụ na ndị na-etinyekwa aka na isi usoro akwara pere mpe na-eche na ọ dị mkpa maka nsogbu ọgbụgba hyperexual, dịka ụzọ mgbaàmà oxygentocin. Nke a microRNA na-egosikwa na a na-echekwa evolushọn na primates niile, nke bụkwa ihe na-atọ ụtọ ma na-atụghị anya ya.
MedicalResearch.com: Kedu ihe ndị na - agụ kwesịrị iwepụ na akụkọ gị?
Azịza: Ọrịa hyperexual gụnyere usoro pathophysiological dị iche iche gụnyere mkparị, mkparị, agụụ mmekọahụ na iri mmadụ ahụ. Enwere ike ịkọwa nke a na ọrịa hypersexual nwere ihe na-eri ahụ, mana a gaghị ahụ ya dị ka ihe riri ahụ. Ihe nchoputa ayi, dika uzo esi akpo mmanya ma obu uzo mmanya, nekwu na MIR4456 na uzo nke oghachighachi oxygen nwere ike tinye aka na ihe riri ahu nke oria obi. A choro omumu ihe omumu iji kwado nke a.
MedicalResearch.com: Kedu ndụmọdụ ị nwere maka nyocha ọdịnihu n'ihi ọrụ a?
Azịza: Nsonaazụ anyị na-akpali nyocha ọzọ na nrụpụta ọrụ, dịka ọmụmaatụ, oxytocin na-achịkwa ọgwụgwọ ọgwụ na nsogbu mmekọahụ rụrụ arụ nke nwere ike inye aka na nhọrọ ọgwụgwọ ọhụụ iji meziwanye nsonaazụ nke ndị ahụ metụtara. Tụkwasị na nke a, anyị na-achọpụta microRNA (miRNA) a kapịrị ọnụ nke a ga-anwale miRNA na-achịkwa ọgwụ ga-eme n'ọdịnihu na nsogbu mmekọrịta nwoke na nwanyị.
MedicalResearch.com: Enwere ihe ọzọ ịchọrọ ịgbakwunye?
Azịza: DNA anyị bụ mkpụrụ ndụ ihe nketa maka mkpụrụ ndụ ihe nketa nke na-atụgharị gaa na usoro dị iche iche nke amino acid a na-akpọ protein. Ndi protein, n’aka nke ha, bu isi ihe na - akowa ihe nile di ndu. DNA anyị bu ihe nketa ma ọ naghị agbanwe oge. Otú ọ dị, ọmụmụ ihe a metụtara epigenetics, nke bụ mgbanwe na-emetụta ọrụ mkpụrụ ndụ na ngosipụta. Ihe ndị a epigenetic na-agbanwe n'oge na-adịghị anya ma enwere ike ịnwe dysregulated na ọrịa ụfọdụ. E nwere usoro epigenetic dị iche iche.
N'ime ọmụmụ ihe a, anyị mụrụ methylation DNA (usoro a maara iji emetụta mkpụrụ okwu, ya bụ, ọnụọgụ nke mkpụrụ ndụ ihe nketa nke atụgharịrị na protein) na ọrụ microRNA (akụkụ mkpụrụ ndụ na-abụghị nke nwere ike imetụta nsụgharị nke ọtụtụ narị mmadụ mkpụrụ ndụ ihe nketa dị iche).
N'iji ndị ọrịa nwere nsogbu ịkwa iko na ndị ọrụ afọ ofufo ahụike, anyị chọpụtara usoro methylation DNA ka a gbanwee n'ụzọ dị ukwuu na nsogbu mmekọrịta nwoke na nwanyị. Iji chọpụta mkpa nke nchọpụta a, otu usoro DNA gosipụtara ọzọ ka ọ bụrụ nke a na-agbanye n'ọbara na mmanya na-aba n'anya, na-atụ aro na enwere ike jikọta ya na ihe na-eri ahụ nke nsogbu mmekọahụ rụrụ arụ. Ejikọtara usoro methylation DNA ahụ na microRNA a na-akpọ (microRNA 4456; MIR4456), na nyocha ọzọ gosipụtara na usoro methylation DNA a na-emetụta oke MIR4456 nke emepụtara. Ọzọkwa, n'otu otu ọmụmụ ihe ahụ, anyị na-egosi na MIR4456 dị oke obere na nsogbu mmekọahụ rụrụ arụ ma e jiri ya tụnyere ndị ọrụ afọ ofufo ahụike, na-atụsi ike na mgbanwe usoro methylation DNA gbanwere na nrụrụ mmekọrịta nwoke na nwanyị ma na-enye aka n'ịkọwapụta dysregulation a hụrụ nke MIR4456. Dị ka microRNA: a na-enwe ike ịchọta ọtụtụ mkpụrụ ndụ ihe nketa dị iche iche, anyị jiri algorithms kọmputa gosipụta na MIR4456 na-eleba anya na mkpụrụ ndụ ihe nketa nke egosiputara na ụbụrụ yana nke na-etinye aka na usoro mkpụrụ ndụ ihe omimi ndị chere na ọ dị mkpa maka HD, eg, oxytocin ụzọ mgbaàmà. Nchọpụta anyị kwesịrị nyocha ọzọ na ọrụ nke MIR4456 na karịsịa Oxytocin na nsogbu mmekọrịta nwoke na nwanyị. A chọkwuru ọmụmụ ihe iji gosi ọrụ nke Oxytocin na HD na iji chọpụta ma ọgwụgwọ na ọgwụgwọ ọgwụ na-eme ka ndị na-eme ihe ike nwere ike inwe mmetụta bara uru maka ndị ọrịa na-arịa ọrịa mmekọahụ rụrụ arụ.
Ma data a na-agbasabeghị edebe maka ọmụmụ ihe na-esochi dị iche iche na-egosi mmụba dị ukwuu n'ọkwa Oxytocin na ndị ọrịa nwere nsogbu ịkwa iko ma e jiri ya tụnyere njikwa, yana mbelata dị ukwuu n'ọkwa oxytocin mgbe ọgwụgwọ gbasara omume ịkpa oke, na-egosi oke ọrụ Oxytocin na nsogbu mmekorita nwoke na nwanyi na ikwu ihe edere na ihe omumu a karie ike. E gosipụtawo nsonaazụ ndị a dị ka akwụkwọ nkwụsịtụ na nzukọ nke Society of Biochi Psychiatry na Mee 2019 ma nyefee ya dị ka akwụkwọ mmado na ACNP na Disemba 2019.
Ntughari:
Adrian E. Boström et al, mgbada metụtara hypermethylation nke microRNA-4456 na ọgba aghara hypersexual na mmetụta putative na akara oxygentocin: Nyocha nyocha methylation DNA nke mkpụrụ ndụ ihe mRNA, Epigenetics (2019). DOI: 10.1080 / 15592294.2019.1656157
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