Behav Brain Res. 2013 Nov 1; 256: 64-71. doi: 10.1016 / j.bbr.2013.07.056.
Garduño-Gutiérrez R, León-Olea M, Rodríguez-Manzo G.
Source
Departamento de Farmacobiología, Cinvestav Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, Delegación Tlalpan, CP 14330, México DF, Mexico; Departamento de Neuromorfología Funcional, Dirección de Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco 101, Col. San Lorenzo Huipulco, CP 14370, México, DF, Mexico.
nkịtị
Oke oke kwere ka ọ kpoo ruo mgbe o ruru agụụ mmekọahụ na-egosipụta mmachi omume mmekọrịta nwoke na nwanyị na-adịte aka (gburugburu 72h) nke enwere ike ịgbaghari site na sistemụ ịlụ ọgụ opioid antagonist. Copulation na-arụ ọrụ usoro mesolimbic dopaminergic (MLS) ma na-akwalite ntọhapụ opioid endogenous. Na mgbakwunye, opioids endogenous, na-arụ ọrụ na mpaghara ventral tegmental mpaghara (VTA), na-agbanwe ọrụ nke MLS.
Anyi choputara na opioids endogenous na-esonye na mmezu oke nke mmekorita nwoke na nwanyi site na iso ndi nnabata VTA opioid na mmekorita ya, enwere ike ịgbagide ndi opioid ndi na emegide ya..
Na omumu a anyi choputara nsonaazụ intra-VTA nke usoro dị iche iche nke naltrexone na - abụghị opioid receptor antagonist naltrexone (0.1-1.0μg / rat) nke esesiri ike omume mmachi nke ụmụ nwoke nwere oke mmekọahụ. Iji kpughee ohere enwere ike nke ndị nabatara VTA rece-opioid na ntughari nke naltrexone nke nwere ike mejuo mmekọahụ, a nwalere mmetụta dị iche iche nke antagonist ahọrọ δ-opioid, naltrindole (0.03-1.0μg / rat).
Nsonaazụ gosipụtara na ntinye intan-VTA nke 0.3μg naltrexone tụgharịrị mmachi mmekọahụ nke oke oke nwere mmekọahụ., egosiputara na onu anumanu nke anumanu nke puru igosi agu adi nke abuo. Intra-VTA enyere naltrindole emeghị ka ike gwụ nwoke na nwoke ọ bụla. Emechara na MLS tinyere aka na iweghachị agụụ mmekọahụ nke sitere na systemal naltrexone na-eweta, na μ-, mana ọ bụghị ndị nnabata δ-opioid na-esonye na nsonaazụ a.. Intra-VTA naltrexone infusion nke ụmụ oke nwoke nwere mmekọahụ nwere mmetụta na-egbochi ọrụ mmekọahụ. A na-atụle nsonaazụ dị iche iche nke intra-VTA naltrexone na oke oke oke nwoke na-egosipụta mmụọ oke na oke oke nwere mmekọahụ..
Copyright © 2013 Elsevier BV Ikike niile echekwabara.
;