Nkwupụta: Ọmụmụ nyochara ọtụtụ neurochemicals na protein ndị metụtara ọgwụ riri ahụ. Nnyocha chọpụtara na otu mgbanwe ndị ahụ na-egosipụta site na otu omume ụmụ oke na-eri nri na nri abụba dị oke mma.
Int J Obes (London). 2012 Dec 11. doi: 10.1038/ij.2012.197.
Sharma S, Fernandes MF, Fulton S.
Source
CRCHUM na Montreal Diabetes Research Center; Ngalaba Nri, Ngalaba Ọgwụ, Université de Montreal, Montreal, Quebec, Canada.
nkịtị
ebumnobi:
Iji chọpụta usoro mmetụta uche na mkpali nke na-eweghachi nri oriri na-atọ ụtọ na-esochi mwepụ nke nri nwere oke abụba (HFD) na neuroadaptations jikọtara ya na neurochemical na mgbanwe omume na-akpata ọrụ dopaminergic.
Ụzọ:
Oke nwoke C57Bl6 oke anyitinyeghachi ya na HFD (58% kcal abụba) ma ọ bụ ihe dabara adaba, nri nwere obere abụba (LFD; 11% kcal abụba) maka izu 6. Na njedebe nke usoro nri, a na-edobe oke oke na nri nke ha, ma ọ bụ HFD na LFD ka ejiri chow nkịtị dochie ya.
A tụrụ onye ọrụ na-agba mbọ na-aza maka sucrose na ụgwọ ọrụ nri dị oke abụba yana ọkwa corticosterone na-akpata nchekasị na nchekasị (elu-gbakwunyere maze). A na-enyocha ọkwa protein maka tyrosine hydroxylase (TH), corticosterone na-ahapụ ụdị 1 receptor (CRF-R1), ụbụrụ neurotrophic kpatara ụbụrụ (BDNF), phospho-CREB (pCREB) na ΔFosB (ụdị splice nke FosB) na amygdala. , nucleus accumbens (NAc) na ventral tegmental area (VTA) site na ọdịda anyanwụ immunoblotting.
Results:
Izu isii nke HFD na-ebute oke ibu dị ukwuu kpalitere sucrose anhedonia, omume nchekasị na hypothalamic-pituitary-adrenocortical axis (HPA) hypersensitivity na nrụgide. Mwepụ na HFD mana ọ bụghị LFDnchekasị nwere ike na ọkwa basal corticosterone yana mkpali kwalite maka sucrose na ụgwọ ọrụ nri dị oke abụba.
Nri abụba dị elu na-adịghị ala ala belatara CRF-R1 yana ịbawanye ọkwa protein BDNF na pCREB na amygdala wee belata TH na mụbara protein ΔFosB na NAc na VTA. Ụgwọ nri dị elu dị elu na ụmụ oke ewepụrụ na HFD dabara na ụbara protein protein BDNF na NAc ma belata okwu TH na pCREB na amygdala.
mmechi:
Anhedonia, nchekasị na uche nke ndị na-akpata nrụgide na-etolite n'oge usoro HFD ma nwee ike inwe ọrụ dị mkpa na usoro ọjọọ nke na-eme ka nri nwere abụba dị elu na mmepe nke oke ibu.. Mwepụ nke HFD na-eme ka nzaghachi nrụgide na-abawanye ma na-eme ka adịghị ike maka nri dị ụtọ site n'ịbawanye omume na-akpali nri. Mgbanwe na-adịgide adịgide na dopamine na akara ndị metụtara plastik na sekit ụgwọ ọrụ nwere ike ịkwalite ọnọdụ mmetụta uche na-adịghị mma, iribiga ihe ókè na nlọghachi nri dị ụtọ.
International Journal of Obesity na-aga n'ihu mbipụta n'ịntanetị, 11 Disemba 2012; doi:10.1038/ij.2012.197.
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