Jurnal Riset Obat lan Alkohol
vol. 2 (2013), Artikel ID 235651, 11
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aja: 10.4303 / jdar / 235651
Eric J. Nestler
Departemen Neuroscience Fishberg lan Lembaga Otak Friedman, Sekolah Kedokteran Gunung Sinai, One Gustave L. Levy Place, Box 1065, New York, NY 10029, USA
Ditampa 2 November 2012; Diperbarui 10 November 2012; Ditampa 20 November 2012
Abstract
ΔFosB iku anggota kulawarga transkripsi saka faktor transkripsi. Nalika kabeh anggota kulawarga liyane didhudhuk kanthi cepet nanging transiently kanggo nanggepi pangguna stimulus akut, ΔFosB unik amarga ngasilake nanggepi stimulasi bola amarga stabilitas protein sing ora normal.
Induksi ΔFosB sing suwe, ing wilayah hadiah otak, kalebu model kecanduan obat-obatan kewan, kanthi bukti sing nuduhake manawa ΔFosB nyengkuyung hadiah lan motivasi lan dadi mekanisme kunci sensitisasi obat lan nambah administrasi obat-obatan . Iki wis divalidasi ing postmortem manungsa, kanthi level ΔFosB sing luwih dhuwur katon ing wilayah ganjaran otak kecanduan.
Minangka faktor transkripsi, ΔFosB mrodhuksi phenotype prilaku kasebut kanthi ngatur ekspresi gen sing spesifik. Kita ngenali sasaran transkriptasi ΔFosB kanthi nggunakake pendekatan gene kandidat uga kanthi nggunakake cara-cara genom-wide. Karya pungkasan wis nganalisa remodeling chromatin-owah-owahan ing modifikasi posttranslational histones lan protein nuklir liyane ing ganja-diatur gen-kanggo delineate mekanisme molekuler rinci dening ΔFosB ngatur ekspresi gen target ing vivo kanggo mediasi synaptic, neural, lan perilaku plasticity. Studi kasebut saka ΔFosB nyedhiyakake wawasan anyar menyang basis molekul kecanduan narkoba, sing nemtokake target anyar kanggo pangembangan terapi.
Cathetan Suku
- IN Alibhai, TA Green, JA Potashkin, lan EJ Nestler, Regulasi fosB lan ekspresi mRNA fosB: ing vivo lan in vitro studies, Brain Res, 1143 (2007), 22-33.
- E. Ang, J. Chen, P. Zagouras, H. Magna, J. Holland, E. Schaeffer, et al., Induksi nuklir faktor-B ing nukleus diakoni dening administrasi kokain kronis, J Neurochem, 79 (2001), 221-224.
- M. Asanuma lan JL Cadet, Methamphetamine-induced increase ing striatal NF-B DNA-binding kegiatan dilemoni ing superoxide dismutase transgenik clurut, Mol Brain Res, 60 (1998), 305-309.
- O. Berton, HE Covington 3rd, K. Ebner, NM Tsankova, TL Carle, P. Ulery, et al., Indikator FosB ing werna abu-abu periaqueductal dening kaku ngakoni respon tanggapan aktif, Neuron, 55 (2007), 289-300.
- JA Bibb, J. Chen, JR Taylor, P. Svenningsson, A. Nishi, GL Snyder, et al., Efek paparan kronis kanggo kokain diatur dening protein neuronal Cdk5, Alam, 410 (2001), 376-380.
- A. Burung, Persepsi epigenetik, Alam, 447 (2007), 396-398.
- TL Carle, YN Ohnishi, YH Ohnishi, IN Alibhai, MB Wilkinson, A. Kumar, et al., Mekanisme mekanisme gumantung Proteasome lan gumantung marang destabilisasi FosB: identifikasi domain degron FOSB lan implikasi? FosB stabilitas, Eur J Neurosci, 25 (2007), 3009-3019.
- J. Chen, MB Kelz, BT Hope, Y. Nakabeppu, lan EJ Nestler, Antigen sing kronis sing kronis kronis: varian stabil saka FosB sing diakibataké ing otak kanthi pangobatan kronis, J Neurosci, 17 (1997), 4933-4941.
- J. Chen, MB Kelz, G. Zeng, N. Sakai, C. Steffen, PE Shockett, et al., Kéwan transgenik kanthi ekspresi gèn ditargetkan ing otak, Mol Pharmacol, 54 (1998), 495-503.
- J. Chen, SS Newton, L. Zeng, DH Adams, AL Dow, TM Madsen, et al., Downregulation saka beta protein penguat CCAAT-enhancer ing tikus transgenik FosB lan electroconvulsive seizure, Neuropsychopharmacology, 29 (2004), 23-31.
- J. Chen, HE Nye, MB Kelz, N. Hiroi, Y. Nakabeppu, BT Hope, et al., Regulasi saka protèin FosB lan FosB kanthi penyakit elektrokonvulsif lan pengobatan kokain, Mol Pharmacol, 48 (1995), 880-889.
- J. Chen, Y. Zhang, MB Kelz, C. Steffen, ES Ang, L. Zeng, et al., Induksi kinase 5-gumantung kinetisan ing hippocampus kanthi kejang elektroconvulsif: peranan FosB, J Neurosci, 20 (2000), 8965-8971.
- CR Colby, K. Whisler, C. Steffen, EJ Nestler, lan DW Self, Fenomena over-panjelasan tipe sel striatal? FosB nambah incentive kanggo kokain, J Neurosci, 23 (2003), 2488-2493.
- D. Damez-Werno, Q. LaPlant, H. Sun, KN Scobie, DM Dietz, IM Walker, et al., Pengalaman narkoba epigenetically primes Fosb gene inducibility in rat nucleus accumbens, J Neurosci, 32 (2012), 10267-10272.
- P. Dobrazanski, T. Noguchi, K. Kovary, CA Rizzo, PS Lazo, lan R. Bravo, Loro-lorone produk saka gen fosB, FosB lan wangun cendhak, FosB / SF, yaiku aktivator transkontrasi ing fibroblas, Mol Cell Biol, 11 (1991), 5470-5478.
- ME Ehrlich, J. Sommer, E. Canas, lan EM Unterwald, Pertunjukan tikus Periadolescent meningkat? Upregulation FosB minangka tanggepan marang kokain lan amphetamine, J Neurosci, 22 (2002), 9155-9159.
- D. Ferguson, N. Shao, J. Koo, J. Feng, V. Vialou, D. Dietz, et al., Urutan generasi sabanjure nggunakake Chip-Seq nyoroti peran penting kanggo SIRT1 ing kepekaan emosional, Planner Meeting Neurosains, Program Nomer 778.09, Masyarakat kanggo Neurosains, New Orleans, LA, 2012.
- AM Graybiel, R. Moratalla, lan HA Robertson, Amphetamine lan kokain ngedhunake aktifitas narkotika ing gen c-fos ing kompartemen striosom-matriks lan bagean limbik striatum, Proc Natl Acad Sci USA, 87 (1990), 6912-6916.
- BA Grueter, AJ Robison, RL Neve, EJ Nestler, lan RC Malenka, FosB beda modulates nukleus kanthi nggayuh fungsi jalur langsung lan ora langsung, Proc Natl Acad Sci USA (kanggo katon).
- VL Hedges, S. Chakravarty, EJ Nestler, lan RL Meisel, ? Overexpression FosB ing accumbens inti nambah ganjaran seksual ing hamster Suriah wadon, Gen Brain Behav, 8 (2009), 442-449.
- N. Hiroi, JR Brown, CN Haile, H. Ye, ME Greenberg, lan EJ Nestler, Tikus mutan FosB: ilang induksi kokain kronis protein sing ana gandhengane Fos lan sensitivitas kanggo psikomotor kokain lan efek sing bermanfaat, Proc Natl Acad Sci USA, 94 (1997), 10397-10402.
- N. Hiroi, GJ Marek, JR Brown, H. Ye, F. Saudou, VA Vaidya, et al., Peranan penting saka gen fosB ing tumindak molekuler, seluler, lan tindak tanduk kejang electroconvulsive kronis, J Neurosci, 18 (1998), 6952-6962.
- B. Hope, B. Kosofsky, SE Hyman, lan EJ Nestler, Regulasi ekspresi gen awal lan AP-1 ngiket ing inti nukleus sing diakoni dening kokain kronis, Proc Natl Acad Sci USA, 89 (1992), 5764-5768.
- BT Hope, HE Nye, MB Kelz, DW Self, MJ Iadarola, Y. Nakabeppu, et al., Induksi komplek AP-1 sing dumadi saka protèin kaya Fosok ing otak kanthi kokain kronis lan pangobatan kronis liya, Neuron, 13 (1994), 1235-1244.
- HJ Jorissen, PG Ulery, L. Henry, S. Gourneni, EJ Nestler, lan G. Rudenko, Dimerisasi lan sifat-sifat transduksi DNA saka faktor transkripsi? FosB, Biokimia, 46 (2007), 8360-8372.
- PW Kalivas lan ND Volkow, Dasar narkotika kecanduan: patologi motivasi lan pilihan, Am J Psychiatry, 162 (2005), 1403-1413.
- GB Kaplan, KA Leite-Morris, W. Fan, AJ Young, lan MD Guy, Sensitisasi opiate ngakibatake FosB / ekspresi FosB ing korteks prefrontal, striatal lan amygdala wilayah otak, PLoS Salah, 6 (2011), e23574.
- JA Kauer lan RC Malenka, Plasticity synaptic and addiction, Nat Rev Neurosci, 8 (2007), 844-858.
- MB Kelz, J. Chen, Carlezon Jr., WA, Jr., K. Whisler, L. Gilden, AM Beckmann, et al. Ekspresi faktor transkripsi? FosB ing otak ngontrol sensitivitas kanggo kokain, Alam, 401 (1999), 272-276.
- A. Kumar, KH Choi, W. Renthal, NM Tsankova, DE Theobald, HT Truong, et al., Remodeling kromatin minangka mekanisme kunci sing ndasari kelenturan kokain ing striatum, Neuron, 48 (2005), 303-314.
- Q. LaPlant dan EJ Nestler, CRACKing kode histone: efek kokain ing struktur lan fungsi kromatin, Horm Behav, 59 (2011), 321-330.
- KW Lee, Y. Kim, AM Kim, K. Helmin, AC Nairn, lan P. Greengard, Pembentukan tulang tonggong dendritik ing Cocaine ing D1 lan D2 dopamin receptor sing ngandhut neuron menengah ing inti sèl accumbens, Proc Natl Acad Sci USA, 103 (2006), 3399-3404.
- ML Lehmann lan M. Herkenham, Pengayaan lingkungan nyebabake kaku sosial kanggo asor sosial liwat jalur neuroanatomi sing gumantung korteks infralimbi, J Neurosci, 31 (2011), 6159-6173.
- A. Levine, Y. Huang, B. Drisaldi, EA Griffin Jr., DD Pollak, S. Xu, et al., Mekanisme molekular kanggo tamba gateway: owah-owahan epigenetik diawali dening expression gen perdana nikotin dening kokain, Sci Transl Med, 3 (2011), 107ra109.
- AA Levine, Z. Guan, A. Barco, S. Xu, ER Kandel, lan JH Schwartz, Protein CREB-binding ngontrol reaksi kokain kanthi histones asetilasi ing promotor fosB ing striatum mouse, Proc Natl Acad Sci USA, 102 (2005), 19186-19191.
- J. Li, Y. Sun, lan J. Ye, Electroacupuncture ngurangi konsumsi alkohol sing berlebihan sing nyebabake pangurangan FosB / FosB tingkat ing gizi sing gegandhengan karo wilayah, PLoS Salah, 7 (2012), e40347.
- HF Liu, WH Zhou, HQ Zhu, MJ Lai, lan WS Chen, Microinjection of M5 reseptor muscarinic oligonucleotide antisense menyang VTA nyegah ekspresi FosB ing NAc lan hippocampus tikus sensitized heroin, Neurosci Bull, 23 (2007), 1-8.
- I. Maze, HE Covington 3rd, DM Dietz, Q. LaPlant, W. Renthal, SJ Russo, et al., Peranan penting saka methyltransferase histone G9a ing plastisitas cocaine-induced, Ilmu, 327 (2010), 213-216.
- CA McClung lan EJ Nestler, Peraturan ekspresi gene lan hadiah kokain dening CREB lan FosB, Nat Neurosci, 6 (2003), 1208-1215.
- CA McClung, PG Ulery, LI Perrotti, V. Zachariou, O. Berton, lan EJ Nestler, ? FosB: switch molekul kanggo adaptasi long-term ing otak, Mol Brain Res, 132 (2004), 146-154.
- J. McDaid, JE Dallimore, AR Mackie, lan TC Napier, Owah-owahan ing pCREB akustik lan pallidal lan FosB ing tikus morfin-sensitized: hubungan karo reseptor-nguripake electrophysiological langkah ing pallidum ventral, Neuropsychopharmacology, 31 (2006), 1212-1226.
- J. McDaid, MP Graham, lan TC Napier, Methamphetamine-induced sensitization differ alters pCREB and? FosB throughout the limbic circuit of brain mammalian, Mol Pharmacol, 70 (2006), 2064-2074.
- C. Mombereau, L. Lhuillier, K. Kaupmann, lan JF Cryan, Pemandhangan modulasi sing dianggep modulasi-reseptor GABAB sing ngasilake nikotin digandhengake karo pangurangan ing akumulasi nukleus? Akumulasi FosB, J Pharmacol Exp Ther, 321 (2007), 172-177.
- R. Moratalla, B. Elibol, M. Vallejo, lan AM Graybiel, Perubahan tingkat jaringan ing ekspresi protèin Fos-Jun induktif ing striatum sajrone perawatan kokain kronis lan mundur, Neuron, 17 (1996), 147-156.
- JI Morgan lan T. Curran, Gen-gen awal: sepuluh taun, Trends Neurosci, 18 (1995), 66-67.
- DL Muller lan EM Unterwald, D1 dopamin receptors modulate? FosB induksi ing striatum tikus sawise intermittent morfin administrasi, J Pharmacol Exp Ther, 314 (2005), 148-154.
- J. Muschamp, C. Nemeth, A. Robison, E. Nestler, lan W. Carlezon Jr., ? FosB nambah efek ganjaran kokain nalika ngurangi efek pro-depresi saka agonist reseptor kappa-opioid U50488, Biol Psikiatri, 71 (2012), 44-50.
- Y. Nakabeppu lan D. Nathans, A wangun FosB sing ditindakake kanthi alami sing nyegah kegiatan transkripsi Fos / Jun, Cell, 64 (1991), 751-759.
- EJ Nestler, Basis molekular long-term kelenturan pendaptaran ndasari, Nat Rev Neurosci, 2 (2001), 119-128.
- EJ Nestler, Mekanisme transkripional saka kecanduan: peran FosB, Philos Trans R Soc Lond B Biol Sci, 363 (2008), 3245-3255.
- EJ Nestler, MB Kelz, lan J. Chen, ? FosB: mediator molekuler saka plastisitas saraf lan tindak tanduk jangka panjang, Brain Res, 835 (1999), 10-17.
- SD Norrholm, JA Bibb, EJ Nestler, CC Ouimet, JR Taylor, lan P. Greengard, Proliferasi spin dendritik ing inti saka accumbens gumantung ing aktivitas kinase-5-gumantung siklus, Neuroscience, 116 (2003), 19-22.
- HE Nye, B. Hope, M. Kelz, M. Iadarola, lan E. Nestler, Pasinaon farmakologi babagan angger-angger antigen sing ana hubungane karo FOS kronis kanthi kokain ing striatum lan nukleus accumbens, J Pharmacol Exp Ther, 275 (1995), 1671-1680.
- HE Nye lan EJ Nestler, Inti saka antigen Fos sing kronis ing otak tikus dening administrasi morphine kronis, Mol Pharmacol, 49 (1996), 636-645.
- P. Olausson, JD Jentsch, N. Tronson, RL Neve, EJ Nestler, lan JR Taylor, ? FosB ing accumbens nukleus ngatur prilaku lan motivasi instrumental sing diperkuat karo panganan, J Neurosci, 26 (2006), 9196-9204.
- MC Peakman, C. Colby, LI Perrotti, P. Tekumalla, T. Carle, P. Ulery, et al., Ekspresi spesifik wilayah otak mutant negatif dominan saka c-Jun ing tikus transgenik ngurangi sensitivitas kanggo kokain, Brain Res, 970 (2003), 73-86.
- LI Perrotti, CA Bolan ~ os, KH Choi, SJ Russo, S. Edwards, PG Ulery, et al., ? FosB nglumpukake ing populasi sel GABAergic ing ekor wingking area tegegalal ventral sawise perawatan psikostimulant, Eur J Neurosci, 21 (2005), 2817-2824.
- LI Perrotti, Y. Hadeishi, PG Ulery, M. Barrot, L. Monteggia, RS Duman, et al., Indikator FosB ing struktur otak sing menehi ganjaran sawise stres nemen, J Neurosci, 24 (2004), 10594-10602.
- LI Perrotti, RR Weaver, B. Robison, W. Renthal, I. Maze, S. Yazdani, et al., Pola sing khas yaiku: FosB induksi ing otak dening obat-obatan penyalahgunaan, Synapse, 62 (2008), 358-369.
- EM Pich, SR Pagliusi, M. Tessari, D. Talabot-Ayer, R. Hooft van Huijsduijnen, lan C. Chiamulera, Substrat saraf umum kanggo sifat adiktif nikotin lan kokain, Ilmu, 275 (1997), 83-86.
- KK Pitchers, KS Frohmader, V. Vialou, E. Mouzon, EJ Nestler, MN Lehman, et al., ? FosB ing accumbens inti penting banget kanggo nguatake efek ganjaran seksual, Gen Brain Behav, 9 (2010), 831-840.
- W. Renthal, TL Carle, I. Maze, HE Covington 3rd, HT Truong, I. Alibhai, et al., ? FosB mediates desensitization epigenetic saka gen c-fos sawise paparan amphetamine kronis, J Neurosci, 28 (2008), 7344-7349.
- W. Renthal, A. Kumar, G. Xiao, M. Wilkinson, HE Covington 3rd, I. Maze, et al., Analisis genom babagan pengaturan kromatin ku kokain ngungkapake peran kanggo sirtuin, Neuron, 62 (2009), 335-348.
- W. Renthal, I. Maze, V. Krishnan, HE Covington 3rd, G. Xiao, A. Kumar, et al. Histone deacetylase 5 epigenetically kontrol adaptasi perilaku kanggo rangsangan emosi kronis, Neuron, 56 (2007), 517-529.
- TE Robinson lan B. Kolb, Plastisitas struktural digandhengake karo paparan obatan penyalahgunaan, Neuropharmacology, 47 (2004), 33-46.
- AJ Robison lan EJ Nestler, Mekanisme transkriptif lan epigenetik saka kecanduan, Nat Rev Neurosci, 12 (2011), 623-637.
- AJ Robison, V. Vialou, M. Mazei-Robison, J. Feng, S. Kourrich, M. Collins, et al., Respon behavioral lan struktural kanggo kokain kronis mbutuhake dobel feed-nerusake nglibatake? FosB lan CaMKII ing inti kloro accumbens shell, J Neurosci (katon).
- SJ Russo, MB Wilkinson, MS Mazei-Robison, DM Dietz, I. Maze, V. Krishnan, et al., Faktor nuklir B signaling ngatur morphology neuronal lan hadiah kokain, J Neurosci, 29 (2009), 3529-3537.
- HJ Shaffer lan GB Eber, Perkembangan temporal gejala katergantungan kokain ing Survey National Comorbidity of the US, Kecanduan, 97 (2002), 543-554.
- T. Shippenberg lan W. Rea, Sensitisasi kanggo efek perilaku cocaine: modulasi dening dynorphin lan agonist reseptor kappa-opioid, Pharmacol Biochem Behav, 57 (1997), 449-455.
- J. Taylor, W. Lynch, H. Sanchez, P. Olausson, E. Nestler, lan J. Bibb, Inhibisi Cdk5 ing accumbens nukleus nambah efek locomotor-activating lan incentive-motivational saka kokain, Proc Natl Acad Sci USA, 104 (2007), 4147-4152.
- SL Teegarden lan TL Bale, Ngurangi ing pilihan dietary gawé tambah emosionalitas lan resiko kanggo dietapse relapse, Biol Psikiatri, 61 (2007), 1021-1029.
- SL Teegarden, EJ Nestler, lan TL Bale, Perubahan FOSB sing ditengahi ing sinyal dopamin ditormalake kanthi diet dhuwur lemak, Biol Psikiatri, 64 (2008), 941-950.
- PG Ulery, G. Rudenko, lan EJ Nestler, Regulasi saka stabilitas FosB dening fosforilasi, J Neurosci, 26 (2006), 5131-5142.
- PG Ulery-Reynolds, MA Castillo, V. Vialou, SJ Russo, lan EJ Nestler, Phosphorylation of? FosB mediates stabilitas ing vivo, Neuroscience, 158 (2009), 369-372.
- V. Vialou, J. Feng, AJ Robison, SM Ku, D. Ferguson, KN Scobie, et al., Serum respon faktor lan protein respon cAMP nanggepi unsur loro sing dibutuhake kanggo induksi kokain saka FosB, J Neurosci, 32 (2012), 7577-7584.
- V. Vialou, I. Maze, W. Renthal, QC LaPlant, EL Watts, E. Mouzon, et al., Faktor reaksi serum nyedhiyakake ketahanan kanggo stres sosial sing kronis liwat induksi FosB, J Neurosci, 30 (2010), 14585-14592.
- V. Vialou, AJ Robison, QC Laplant, HE Covington 3rd, DM Dietz, YN Ohnishi, et al., ? FosB ing sirkuit ganjaran otak ngirangi ketahanan kanggo kaku lan respon antidepresan, Nat Neurosci, 13 (2010), 745-752.
- DL Wallace, V. Vialou, L. Rios, TL Carle-Florence, S. Chakravarty, A. Kumar, et al., Pengaruh FosB ing inti kasebut akrab karo prilaku sing ana gandhengane karo ganjaran, J Neurosci, 28 (2008), 10272-10277.
- Y. Wang, TI Cesena, Y. Ohnishi, R. Burger-Caplan, V. Lam, PD Kirchhoff, et al., Pemeriksaan molekul kecil mengidentifikasi regulator faktor transkripsi? FosB, ACS Chem Neurosci, 3 (2012), 546-556.
- M. Werme, C. Messer, L. Olson, L. Gilden, P. Thorén, EJ Nestler, et al., ? FosB ngaturake roda mlaku, J Neurosci, 22 (2002), 8133-8138.
- CA Winstanley, RK Bachtell, DE Theobald, S. Laali, TA Green, A. Kumar, et al., Tambah impulsivity sak mundur saka kokain administrasi: peran kanggo? FosB ing cortex orbitofrontal, Cereb Cortex, 19 (2009), 435-444.
- CA Winstanley, TA Green, DE Theobald, W. Renthal, Q. LaPlant, RJ DiLeone, et al., ? Induksi FosB ing corteks orbitofrontal ngalami sensitisasi sensitivitas lokomotif sanajan ngatasi disfungsi kognitif sing disebabake dening kokain, Pharmacol Biochem Behav, 93 (2009), 278-284.
- CA Winstanley, Q. LaPlant, DE Theobald, TA Green, RK Bachtell, LI Perrotti, et al., ? Induksi FosB ing korteks orbitofrontal mediates toleransi kanggo cocaine-induced disfungsi kognitif, J Neurosci, 27 (2007), 10497-10507.
- J. Yen, RM Wisdom, I. Tratner, lan Verma, Wangun singkatan alternatif FosB minangka regulator negatif kanggo aktivasi transklusi lan transformasi dening protèin Fos, Proc Natl Acad Sci USA, 88 (1991), 5077-5081.
- ST Young, LJ Porrino, lan MJ Iadarola, Cocaine ngasari protèin c-fos-immunoreaktif striat liwat reseptor D1 dopaminergik, Proc Natl Acad Sci USA, 88 (1991), 1291-1295.
- V. Zachariou, CA Bolanos, DE Selley, D. Theobald, MP Cassidy, MB Kelz, et al., Peranan sing penting kanggo? FosB ing nukleus akrab ing tumindak morfin, Nat Neurosci, 9 (2006), 205-211.