COMMENTS: Delta-FosB shine sinadaran kwakwalwa (sashin kwafi) mai mahimmanci a cikin samuwar jaraba. Ya samo asali ne a cikin "ƙwarewar yanayi," kamar yawan cin abinci mai ƙanshi / mai ƙanshi, da kuma yawan motsa jiki da motsa jiki (kuma babu shakka, jarabar batsa). Wasu majiyoyi suna ba da shawarar cewa ya ragu kusan mako na 6-8 na ƙauracewa abu ko halayyar maye.
By William McCall
http://biopsychiatry.com/cocaine/index.htm
Cocaine na iya kasancewa daya daga cikin maganin da ya fi dacewa don warkewarta domin yana haifar da gina wani furotin da ke ci gaba a cikin kwakwalwa kuma yana karfafa kwayoyin da ke ƙarfafa sha'awar magani, sabon bincike ya nuna.
Masana kimiyya a Cibiyar Yale ta Yale sun iya warewa mai gina jiki mai tsawo, wanda aka kira Delta-FosB, kuma ya nuna cewa ya haifar da jaraba lokacin da aka saki zuwa wani yanki na ƙwararren ƙwayar ƙarancin gingwani.
Ba a samar da furotin (wanda ake kira fawz-bee) a cikin kwakwalwa har sai wadanda suka kamu da cutar sun yi amfani da hodar iblis sau da yawa, ko ma tsawon shekaru. Amma da zarar ginin ya fara, buƙatar magani ya zama da ƙarfi kuma halayen mai amfani yana ƙara zama mai tilastawa.
"Kusan kamar canza kwayoyin ne," in ji Eric Nestler, wanda ya jagoranci binciken. Da zarar an kunna shi, zai ci gaba, kuma baya tafiya cikin sauki. ”
Abubuwan da aka gano, wanda za a buga a ranar Alhamis a cikin mujallar Nature, an kira su da "kyakkyawa" da "mai haske" daga wasu masu binciken waɗanda suka ce ya ba da tabbaci na farko na tabbaci cewa amfani da miyagun ƙwayoyi yana haifar da takamaiman canjin canjin kwakwalwa.
Nazarin ya nuna jinsin halitta ba shi da mahimmanci a cikin jaraba fiye da amfani da miyagun ƙwayoyi na tsawon lokaci, in ji Alan Leshner, darektan Cibiyar Nazarin Kasuwancin Drug, wadda ta ba da tallafi ga wani binciken.
Leshner ya ce: "Kwayoyin halittar ku ba su yanke muku hukuncin zama mashaya ba,"
“Suna kawai sa ku ƙari, ko lessasa, mai saukin kamuwa. Ba mu taba samun kwayar halitta guda daya da za ta hana ka zama mashaya ba, ko kuma wacce ke nuna za ka zama mai shan tabar ba. ”
Nestler da abokan aikinsa sun hada da kwayoyin halitta da binciken binciken kwayoyin halitta don warewa da furotin Delta-FosB da kuma yanayin kwakwalwa ya shafi, sannan kuma ya yi nazari kan halayen.
Da zarar matakin Delta-FosB ya tara, sai ya fara tsara kwayoyin da ke kula da yankin da kwakwalwa da ake kira tsakiya, wanda yake da tasiri game da halayyar ƙwayar cuta da kuma jin dadi.
Sun ɗauka cewa Delta-FosB yana kunna sauran kwayoyin da ke samar da kwayoyin halitta mai suna "glutamates", wanda ke dauke da saƙonni a cikin kwakwalwa. Masu karɓa a cikin kwakwalwa kwayoyin sun zama masu karuwa sosai, musamman ma a cikin mahallin.
Don gwada ka'idar, sun shigar da kwayar halittar da ke hade da glutamate cikin kwayar halittar berayen gwaji. Wadannan berayen sun nuna karuwar "mai ban mamaki" a cikin halayyar cocaine, sun ruwaito.
"Wannan babban ci gaba ne a fahimtarmu game da jaraba," in ji Francis White, shugaban kwayar kimiyyar salula da kwayoyin a Jami'ar Finch ta Kimiyyar Kiwon Lafiya a Chicago.
Sauran masu bincike sun fi hankali, suna lura cewa tsangwama abu ne mai rikitarwa a cikin mutane saboda an danganta shi da ilmantarwa da hanyoyi masu yawa a kwakwalwa.
"Ba a bayyane ya ke gare ni ba cewa akwai wata hanyar kwayar halitta ta daban wacce za a sanya wa shan miyagun kwayoyi kuma ba ta tsoma baki tare da sauran ilmantarwa," in ji Gary Aston-Jones na Makarantar Koyon Magunguna ta Jami'ar Pennsylvania.
Abin sha'awa ga cocaine zai iya zama mai karfi, mai shan magani wanda ya yi guje wa miyagun ƙwayoyi don shekaru yana iya fara ji daɗin zuciyarta kawai ta hanyar ganin wani abu da ke hade da amfani da miyagun ƙwayoyi, irin su lissafi na $ 100 ko kusurwar hanya ta gari, Aston- Jones ya ce.
"Kuna son fitar da ƙwaƙwalwar don magani amma ba ku so ku fitar da ƙwaƙwalwar don hanyar zuwa gida," in ji shi.
Steve Hyman, darektan Cibiyar Harkokin Kasuwancin Cibiyar Nazarin Harkokin Lafiya, ya ce binciken ya nuna cewa gina gina jiki na Delta-FosB zai iya zama wani abu tare da wasu kwayoyi, ciki har da amphetamine, morphine, heroin da nicotine.
Hyman ya ce "Wannan muhimmiyar matattakala ce amma akwai doguwar hanyar tafiya,"
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