Mutane da yawa matasa mutanen da ba su da wata cuta ba tare da wata kuskure ba, suna zaton cewa ƙaramin testosterone dole ne a zargi. Wannan ba shi yiwuwa ba kamar yadda sosai kananan testosterone yana buƙatar cimma burbushi, ɗakunan ED da yawa ba su nuna dangantaka tare da testosterone ba, kuma T da ƙarin T yana da tasiri a cikin marasa lafiya mai kwakwalwa.
Matakan ƙwayoyin testosterone na Plasma na aiki da jima'i da maza.
Arch Jima'i Behav. 1980 Oct;9(5):355-66.
Schwartz MF, Kolodny RC, Masters WH.
Abstract
Matakan testosterone na Plasma a cikin rukuni na maza 341 da ke fama da lalata ta jima'i idan aka kwatanta da waɗanda ke cikin maza 199 tare da aikin jima'i na yau da kullun. Dukkanin batutuwa sun kasance mahalarta a cikin shirin sati 2 mai saurin haɗuwa game da ilimin jima'i a Cibiyar Masters & Johnson. An yanke shawarar Testosterone ta amfani da hanyoyin radioimmunoassay bayan shafi chromatography; duk samfuran jini an same su a rana ta biyu na farwa tsakanin 8:00 da 9:00 na safe bayan azumin dare. Rigilar kwayoyin testosterone a cikin maza da halayen jima'i (ma'anar 635 ng / dl) ba su da bambanci da dabi'un testosterone a cikin mazaunin dysfonctional (nufin 629 ng / dl). Koyaya, maza masu rashin ƙarfi na farko (N = 13) suna da mahimmancin matakan testosterone fiye da maza masu rashin ƙarfi na biyu (N = 180), tare da ƙananan matakan 710 da 574 ng / dl, bi da bi (p <0.001). Matsakaicin matakin testosterone ga maza masu fama da rashin ingancin abu shine 660 ng / dl (N = 15), yayin da ga maza masu saurin kawowa ma'anar su 622 ng / dl (N = 91). Magungunan testosterone na Plasma ba su da alaƙa da sakamakon farfadowa amma an haɗu da su daidai da shekarun marasa lafiya.
Aikin kwayoyin cutar Pituitary yana aiki a marasa lafiya da rashin ciwon daji da tsohuwar haɗari.
Arch Jima'i Behav. 1979 Jan;8(1):41-8.
Pirke KM, Kockott G, Aldenhoff J, Besinger U, Feil W.
Abstract
Anyi nazarin tsarin gwajin kwayar cutar a cikin maza tare da rashin ƙarfi. Magunguna takwas da ke fama da rashin ƙarfi a shekarun haihuwa 22-36, maza takwas da ke fama da rashin ƙarfi a shekara ta 29-55, da kuma maza 16 da ba su kai ƙarfin tsufa ba. Ungiyar ta ƙarshe an sake raba ta zuwa ƙungiyoyi biyu: E23 (n = 43) marasa lafiya ba tare da E1 (n = 7) marasa lafiya da damuwa da halayyar kauce wa aiki na aure ba. Goma sha shida baligi manya masu shekaru 2-9 sunyi aiki a matsayin ƙungiyar kulawa. An gudanar da ganewar asali bayan bincike na tabin hankali da na jiki. Maganin da suka yi la'akari da asarar libido basu kasance cikin binciken ba. An samo samfurori na jini guda goma a cikin tsawon 3 Hr daga kowane mai haƙuri. An auna nau'in hormone na Luteinizing (LH), jimlar testosterone, da kuma free (ba gina jiki) testosterone. Rikici na lissafin bayanai bai nuna bambancin dake tsakanin marasa lafiya da kulawar al'ada ba.
Magunguna da ƙwayoyin testosterone da testosterone a cikin maza da rashin ƙarfi, oligospermia, azoospermia, da hypogonadism.
Br Med J. 1974 Mar 2;1(5904):349-51.
Abstract
Matsakaicin matakan plasma testosterone (+/- SD), ta amfani da Sephadex LH-20 da haɗin gasa mai ƙarfi, sun kasance 629 +/- 160 ng / 100 ml don ƙungiyar 27 manya maza, 650 +/- 205 ng / 100 ml don 27 maza marasa ƙarfi tare da halayen jima'i na yau da kullun, 644 +/- 178 ng / 100 ml don maza 20 tare da oligospermia, da 563 +/- 125 ng / 100 ml na 16 azoospermic men. Babu ɗayan waɗannan ƙimomin da ya bambanta da muhimmanci. Ga maza 21 tare da shaidar asibiti na hypogonadism maƙasudin ƙwayar plasma testosterone (+/- SD), a 177 +/- 122 ng / 100 ml, ya bambanta sosai (P <0.001) daga na maza na al'ada.Matsanancin ka'idar testosterone (kamar yadda aka kwatanta da yawan plasma da ake buƙatar ɗaure 50% na (3) H-testosterone tracer) sun kasance kama da al'ada, marasa ƙarfi, da kuma maza na oligospermic. Kodayake mafi ƙanƙanta ga mazajen azoospermic amma bambancin bashi da mahimmanci (P> 0.1). Don 12 na 16 hypogonadal maza haɗin testosterone haɗuwa daidai ne, amma haɓaka alaƙa, kama da waɗanda aka samo a cikin mata na al'ada ko kuma yara maza masu balaga (kusan sau biyu na maza manya), an same su a cikin abubuwa huɗu na jinkirta balaga. Wadannan binciken sun taimaka wajen bayyana dalilin da yasa magungunan inrogen din yakan zama mara amfani a cikin maganin rashin ƙarfi.
Shin testosterone yana da rawar gani a aikin aiki?
Am J Med. 2006 May;119(5):373-82.
KASHI:
Duk da ci gaban da aka samu na testosterone wajen inganta libido, ainihin gudunmawar da aka yi a cikin mutane ya kasance marar ganewa. Makasudin manufofin wannan bita shine ya bayyana muhimmancin testosterone a cikin aikin tsararraki kuma yayi la'akari da muhimmancin lafiyar maza da ciwon daji (ED).
MUTANE:
An yi nazari game da wallafe-wallafe masu dacewa (Turanci, Faransanci, da Mutanen Espanya) daga 1939 zuwa Yuni 2005 ta yin amfani da asusun bayanai daga MEDLINE, littattafai na ƙarshen rubutun kalmomi, da kuma neman hannu akan nassoshi na giciye daga asali na asali da sake dubawa. Kwalejin gwaji, nazarin dabba, rahotanni, sake dubawa, da kuma jagororin manyan ƙungiyoyi sun hada.
Sakamakon:
Nazarin dabba da samfurin mutum na farko ya nuna cewa testosterone na iya sauƙaƙe kafaɗa ta hanyar yin aiki a matsayin ƙananan kwalliya na ƙananan kwakwalwa da launi. Bayan gyare-gyare, mafi yawa, amma ba duka ba, mutane suna da hasara ko tsararre. Hypogonadism ba sananne ne a cikin ED ba, yana faruwa a game da 5% na lokuta, kuma a gaba ɗaya, akwai rashin ƙungiya tsakanin matakan kwayoyin testosterone, yayin da suke a cikin al'ada ko ƙananan ƙananan matakan, da kuma aikin aiki.
Yawancin gwaje-gwaje ta yin amfani da kwayoyin testosterone don maganin ED a cikin mazaunan hypogonadal suna fama da matsalolin hanyoyin da kuma bayar da rahoto marasa dacewa, amma gaba ɗaya, suna ba da shawarar cewa testosterone na iya zama mafi tsayi ga placebo. Ayyukan erectile zai iya ingantawa tare da maganin testosterone a marasa lafiya da darajar hypogonadism.
Sanarwar Testosterone na iya bunkasa amsawa ga magungunan 5 (PDE5) wadanda ke cikin magunguna da maza da maza da testosterone marasa ƙarfi. Maimaita yawan nauyin sallar sautin duka testosterone shine hanya mai sauƙi da sauƙi don kimanta androgenecity, amma ana bada shawara akan freetostailable testosterone a cikin yanayin da ke canza matakan jinsi-hormone-ɗaure globulin (SHBG), irin su tsofaffi da kuma a cikin kiba.
TAMBAYOYI:
Bayanan da ke samuwa sun nuna cewa a mafi yawan maza suna rarraba matakan testosterone, da kyau a ƙarƙashin al'ada, suna da mahimmanci don tsararren al'ada kuma thatta mafi girma daga kwayoyin testosterone bazai da tasiri mai yawa a kan aikin aiki. Kulawa ga hypogonadism a cikin dukan mutane tare da ED ya zama dole don gano lokuta na hypogonadism mai tsanani da kuma wasu lokuta na hypogonadism mai sauƙi, wanda zai iya amfana daga maganin testosterone.
Muhimmancin hypogonadism a cikin dysfunction erectile.
Duniya J Urol. 2006 Dec;24(6):657-67.
Abstract
Don sake nazarin muhimmancin hypogonadism, wanda aka bayyana a matsayin matakin ƙananan testosterone (T), a cikin dysfunction erectile (ED). Review na wallafe-wallafen.
Serum T yana ƙasa da 3 ng / ml a 12% na marasa lafiya ED, ciki har da 4% kafin da 15% bayan shekaru 50. Sauyawa a cikin mazajen da ke dauke da hypogonadism mai tsanani ya nuna cewa sha'awar jima'i da ƙwaƙwalwa, da kuma yawan lokacin yin jima'i da kuma tsararren lokaci ba su da tabbaci. Ƙwararrakin ƙwayoyin cuta suna dogara da T-dogara. Hanyoyin T a kan aikin jima'i sun dogara ne da mutum ɗaya, amma yana iya canzawa tsakanin mutane, daga 2 zuwa 4.5 ng / ml. Ana buƙatar ƙarin shaida don tabbatar da tasiri mai tasiri na T a kan tsarin ƙwayoyin cuta na jikin mutum kamar yadda yake a cikin dabbobi.
Ba a samu ƙungiyar T tare da ED a cikin nazarin annoba ba. Dangane da gwagwarmayar kwarewa, kodayake samfurin maganin gwajin gwagwarmayar da aka bazu ya tabbatar da cewa T na farfadowa da aikin sa a cikin marasa lafiya na hypogonadal tare da T a karkashin 3.46 ng / ml, sakamakon wannan jiyya sun kasance mafi muni lokacin amfani dasu a cikin marasa lafiya yin shawarwari ga ED waɗanda aka gano bayanan sun sami hypogonadism bayan bin aikin T na yau da kullum. Wadannan mummunar sakamako zasu iya yiwuwa a bayyana su ta hanyar yawan kwakwalwar cutar, tare da gaskiyar cewa ED kanta na iya haifar da hypogonadism.
Haɗin haɗawa tare da T da PDE5 mai hanawa (PDE5I) na iya zama tasiri a cikin marasa lafiya ED yayin da T kawai farfadowa ya kasa. Duk da haka, ana buƙatar ƙarin shaida don tabbatar da ra'ayin cewa an buƙatar ƙarami na T don cikakkiyar sakamako na PDE5I a wasu mutane, tun da PDE5I ya iya mayar da cikakke kayan aiki a cikin mutane mai tsanani. Kodayake ƙananan matakin T ba koyaushe ne kawai dalili na ED a hypogonadal ED marasa lafiya, akwai wasu mahimmancin amfani a tantancewa ga hypogonadism a ED. Tashin ƙananan matakin T ya ƙaddara gwajin 3 watanni na T, kafin hada PDE5I idan T kawai farfadowa ya kasa.
;