By GINA KOLATA
FEB. 17, 2016
David Bostick, 71, a gida a Pittsburgh. Bayan 'yan makonni na sukar gel a cikin ciki - bai san idan yana da testosterone ko wuribo - ya fara jin daxi. Ya yi tsammani cewa yana samun testosterone. Credit Jeff Swensen don The New York Times
Fiye da mutane miliyan sun smeared testosterone gels a jikinsu a cikin 'yan shekarun nan, da fatan zai mayar da su, karfafa su, kuma ƙara musu libido. Amma har sai yanzu, akwai taba kasancewa wani rigorous binciken tambayar idan akwai wasu hakikanin amfani ga testosterone far ga lafiya maza da ake kira low T.
Sakamakon farko na irin wannan bincike An wallafa shi a Laraba a The New England Journal of Medicine. Ko da yake an samo shi a mafi yawan amfani mafi kyau, mafi yawa a aikin jima'i, yana da binciken ƙasa, in ji Dokta Eric S. Orwoll, farfesa a fannin ilimin likita a Oregon Health and Science University, domin yana samar da bayanai na farko da suka faru akan cutar testosterone akan wasu matsalolin da ake zaton su warware.
Wasu likitoci sun ce sunyi fatan tsauraran sakamakon za su iya haifar da sanyaya ga ƙyamar testosterone na 'yan shekarun nan. "A gaskiya," in ji Dokta Sundeep Khosla, wani dan jarida a Cibiyar Kwalejin Ciwon Magunguna ta Mayo, "akwai mummunan zalunci." Maza maza da aka lalata ta hanyar tallace-tallace sun nemi magani, Dokta Khosla ya ce ya ji likitocin da suka tsara shi ba tare da aunawa ba matakan testosterone mutum don ganin idan sun kasance low.
Kowane mako, za mu kawo muku labarai masu ɗauke da abubuwan al'ajabi na jikin mutum, yanayi da sararin samaniya. Yana nan tafe.
"Abin da nake fata shi ne wannan zai kawo mahimmanci mahimmanci," In ji Dokta Orwoll. "Akwai abubuwa da dama da ke bayyanawa a can, kuma ba ya da kama, ga mutum mai matsakaici, zai yi babban tasiri."
Nazarin, jagorancin Makarantar Medicine na Perelman a Jami'ar Pennsylvania kuma ya biya ta National Confucius Lafiya da kuma AbbVie, mai ƙirar gel AndroGel na testosterone, sun hada da 790 maza 65 da kuma tsofaffi tare da matakan testosterone marasa tushe a shekarunsu.
Matakan Testosterone sukan fada a lokacin da suke da shekaru, amma waɗannan maza suna da matakan a kan ƙananan ƙarshen - a karkashin 275 zane-zane ta kowace ƙwayar jini. Wasu daga cikin mutanen sun ce sun rasa halayensu, wasu sun ce suna tafiya da sauri fiye da yadda suka saba, kuma wasu sun ce sun ji kamar sun rasa rayukansu. An ba da waɗannan mazajen amfani da AndroGel ko wuribo na shekara guda.
Kamar yadda ake tsammani, mutanen da suka yi amfani da AndroGel sun ƙare tare da matsayi mafi girma na ka'idar testosterone - daga mazaunan 19 zuwa 40. Amma tambayar da masu bincike suka so su sani shi ne: Shin sun ji ko aikata wani abu daban?
Maza maza da suka ce halayen jima'i sun kasance suna nuna cewa suna da karuwa sosai a cikin sha'awar jima'i da kuma yadda suke yi, koda kuwa idan aka yi amfani da kwayoyi, Viagra or Cialis zai zama mafi tasiri, masu bincike sun ruwaito. Wadanda suka ce sun ji dadi sun nuna karamin cigaban yanayi. Amma maganin miyagun ƙwayoyi ba shi da wani tasiri game da muhimmancin gaske ko yin gudun hijira cikin maza tare da waɗannan takunkumi.
Binciken ya yi ƙanƙara da gajeren lokaci don magance wata tambaya mai tsawo a kan gels testosterone: ko yin amfani da su yana kara yawan cutar cututtukan zuciya da prostate ciwon daji da sauran yanayi. Kuma wannan, in ji Dokta Richard J. Hodes, darektan Cibiyar Harkokin Kasuwancin {asa, ta yi hankali.
Game da 15 shekaru da suka wuce, damuwa game da yawan mutanen da ke amfani da kwayoyin testosterone, Dokta Hodes da masu gudanarwa a Sashen Tsohon Kasuwanci sun nuna wata babbar jarrabawar gwaji wanda zai kunshi dubban maza, ci gaba har tsawon shekaru kuma gano ainihin abin da hadari da Abubuwan da suka dace da maganin testosterone sun kasance. Amma shirin ya gudu cikin juriya.
Akwai mawuyacin haɗari ga maza da ke ciki, in ji masu sukar. Ba kawai hadarin ba ciwon daji kuma, daga baya ya fito, yiwuwar cututtukan zuciya, amma batun da PSA gwaje-gwaje, gwaje-gwaje na jini da aka yi amfani da su don nunawa ga ciwon ciwon gurba. Testosterone yana ƙaruwa matakan PSA. Maza maza da manyan matakan sukan samo biopsies daga cikin karuwanci don neman ciwon daji. Amma a cikin gwaji mai gwaji, masu bincike basu san wanda ke samun magani ba kuma wanda ke samun wuribo. Don haka dubban maza da ke dauke da testosterone zasu iya kawo karshen kwayoyin halittun da suka fito daga PSA kawai wanda miyagun ƙwayoyi suka tashe, ba ta hanyar ciwon daji ba.
Dokta Hodes ya koma Cibiyar Nazarin Medicine don jagora. Kungiyar likita a can shawarci fara kananan. Yi bincike, sun ce, wannan na farko ya tambaya idan akwai wani amfani ga testosterone a cikin tsofaffin maza masu lafiya da ƙananan matakan hormone. Idan babu wani amfani, me ya sa yasa kalubalen?
Sabuwar binciken shine sakamakon. Gelin testosterone da mazajen binciken suke amfani da su ba su da karfi kamar yadda yawan kwayoyin testosterone da sauran irin kwayoyin halittar sune sunyi inganci don bunkasa tsoka da inganta aikin.
Wasu maza da ke da mummunar yanayin kiwon lafiya wanda ke ƙazantar da jikin su na kwayoyin cutar kwayoyin halitta suna amfani da hormone a matsayin farfadowa kuma wannan aikin ba shi da wata tambaya, in ji masu bincike. A halin yanzu maza ne waɗanda matakan testosterone sun sauke kawai saboda sun tsufa.
Domin David Bostick, dan jarida na 71 mai shekaru Pittsburgh wanda ya halarci binciken, addu'ar testosterone shi ne cewa zai iya taimakawa tare da rashin jin daɗi kuma ya rage libido. Bayan 'yan makonni na sintiri na gel - bai sani ba idan yayi AndroGel ko wuribo - a cikin ciki, ya fara jin bambanci, da sha'awar jima'i da karin makamashi. Ya tsammani dole ne ya sami testosterone. Lokacin da binciken ya ƙare, sai ya ga likita na farko kuma ya sami takardar izini ga AndroGel. Ya san cewa akwai yiwuwar hadarin amma ya ce, "Na yanke shawarar yanke shawarar daukar shi." A ranar Asabar, sai ya karbi wasika daga binciken da ya faɗa masa abin da yake cikin gel da ya yi amfani da shi. Yana da testosterone.
Amma damuwa kan hadarin yana ci gaba. Yau na ƙarshe, Abinci da Drug Administration sanar cewa ya tambayi masu yin maganin testosterone suyi babban gwaji don tantance ko akwai cututtukan zuciya da kwayoyi. Kamfanonin suna aiki akan tsara shi, in ji Morry Smulevitz, mai magana da yawun AbbVie.
A halin yanzu, likitoci sun rabu akan ko don karfafa damun binciken. Dokta William Bremner, farfesa a fannin ilimin likita a Jami'ar Washington, ya ce yanzu, yana da karfi, idan bayanan gajeren lokaci, zai iya fada wa maza da ke da matakan ƙananan testosterone cewa magani, "abu mai kyau ne don tunani game da yin. "
Dokta Joel Finkelstein, farfesa a fannin ilimin likita a Harvard, ya kasance ba shi da kyau. "Testosterone ba fili ba ne panacea," inji shi. Ya damu game da rashin bayanai game da hadarin da ake dadewa da damuwa game da ƙarfafa yawan mutane don yin amfani da miyagun ƙwayoyi ba tare da sanin amsoshin ba. A yanzu, yana so ya san ƙarin bayani game da wanda zai iya amsawa don kauce wa nuna yawan mutane zuwa hadarin gaske.
Amma yana son babban gwajin gwaji ya ci gaba, koda kuwa yana nufin magance matsalar PSA.
"Ina ganin akwai wajibi ne," in ji Dr. Finkelstein.
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