Comments: Deltafosb yana da nasaba da bambancin, wanda ya kasance kamuwa da nau'in tantanin halitta da aka kunna ta hanyoyi daban-daban.
Abstract
ΔFosB sunadarai a cikin striatum don mayar da martani ga ci gaba da maganin magungunan, L-DOPA, ko danniya, da ke haifar da canjin yanayin da zai kasance mai dorewa da kuma halin canjin da ke haifar da wasu kwayoyi addiction, abubuwan haɗari masu haɗari (dyskinesia), da kuma bakin ciki.
ΔFosB yana ɗaure AP-1 DNA yarjejeniya da aka samo a cikin masu tallafawa da kwayoyin da yawa kuma zai iya dakatarwa ko kunna rikodin gizon. A cikin striatum, ana tunanin ΔFosB don bunkasa tare da JunD don ƙirƙirar ƙididdigar aikin aiki, kodayake JunD ba ya tara a cikin layi daya.
Ɗaya daga cikin bayani shi ne, ΔFosB zai iya daukar nauyin daban-daban, ciki har da kanta, dangane da nau'in nau'in nau'i wanda aka jawo shi da kuma cigaba da cigaba, samar da hanyoyin gina jiki tare da tasiri daban-daban akan rubutun kwayoyin halitta.
Don bunkasa sunadarai bincike don nazarin ΔFosB, an gudanar da allo mai mahimmanci don gano kananan ƙwayoyin da ke tsara aikin ΔFosB. Ma'aikata biyu tare da aikin micromolar m, wanda ake kira C2 da C6, sun rushe ɗaukar ΔFosB zuwa DNA ta hanyoyi daban-daban, kuma a cikin gwajin in vitro na ƙarfafa takardun da aka tsara na ΔFosB. A cikin ƙwayayyen maganin cocaine, C2 yana ɗauke da matakan mRNA na karbaccen gwanin AMG glutamate GluR2 tare da ƙayyadadden bayanai, wani nau'i mai mahimmanci na ΔFosB wanda ke taka rawar a cikin miyagun ƙwayoyi addiction da kuma abubuwan da suka dace. C2 da C6 suna nuna ayyukan daban-daban ga masu bin ΔFosB idan aka kwatanta da ΔFosB / JunD heterodimers, suna nuna cewa wadannan mahadi zasu iya amfani dashi don bincike don taimakawa wajen tallafawa daban-daban ΔFosB-ƙunshe da ƙaddarar rubutun kwayoyin halitta a tsarin nazarin halittu da kuma tantance mai amfani da ΔFosB a matsayin manufa mai warkewa.
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