Neurosci Lett. 2015 Maris 4; 589: 1-6. doi: 10.1016/j.neulet.2015.01.019.
Zhang C 1 , Wei NL 2 , Wang Y 3 , Wang X 3 , Zhang JG 1 , Zhang K 4.
Abstract
Manufar wannan binciken shi ne a tantance tasirin kwayar cutar kibau (NAc-sh) mai zurfin motsawar kwakwalwa (DBS) a cikin kiba da ake samu a cikin abinci (DIO) da berayen da aka ba su (chow). An kuma kimanta tasirin DBS akan siginar dopamine (DA) a cikin NAc-sh. DIO da berayen da aka sara wa DBS na tsawon kwanaki 14 a jere. Ana auna yawan cin abinci da karin nauyi a kowace rana. Bayanin kwayar halitta na masu karban dopamine D1 da D2 an kimanta ta qPCR. Bugu da kari, matakan da ke dauke da kwayoyin halitta na DA da abin da ke narkewa, dihydroxyphenylacetic acid (DOPAC), an tantance su ta microdialysis. Mun lura cewa DBS na yau da kullun ya haifar da raguwa mai yawa a cikin yawan cin kuzari (596.0 ± 65.0kcal vs. 1161.6 ± 22.2kcal, p <0.001) da ƙimar nauyi (1.45 ± 0.57% vs. 9.64 ± 0.38%, p <0.001) a cikin berayen DIO idan aka kwatanta da berayen sham-DIO. An lura da haɓakar mai karɓar mai karɓar D2 ta sama (2.43 ± 0.12 vs. 0.64 ± 0.04, p <0.001) da haɓaka matakan DA (2.73 ± 0.15pmol / mL vs. 0.62 ± 0.05pmol / mL, p <0.001) a cikin berayen DIO idan aka kwatanta da berayen sham-DIO. DBS ba ta da tasiri a kan cin abinci, karuwar nauyi, ko DA neurotransmission a cikin berayen da ke sara. Sakamakonmu yana tallafawa ƙungiya game da tasirin rashin abinci na NAc-sh DBS tare da sigina na mesolimbic DA kuma yana nuna cewa canji mai kyau na DA aiki a cikin berayen DIO na iya zama alhakin tasirin daban-daban na DBS a cikin DIO da ɓawon beraye.
KALMOMI MAI MUHIMMANCI: Zurfin motsa kwakwalwa; Dopamine; Nucleus yana ƙara harsashi; Kiba
PMID: 25578952