Behav Brain Res. 14 ga Yuli 2017;330:46-55. doi: 10.1016/j.bbr.2017.05.014.
Camacho A 1 , Montalvo-Martinez L 2 , Cardenas-Perez RE 2 , Fuentes-Mera L 3 , Garza-Ocañas L 4.
Abstract
Halayen yanayin yanayin abinci suna buƙatar yanayin kwanciyar hankali na glutamatergic neurotransmission a cikin tsarin sakamako, wanda ya shafi canje-canje a cikin bayanin ciki har da wani-amino-3-hydroxy-5-methylisoxazole 4-propionate receptors (AMPA), N-methyl-d-aspartic acid (NMDA) ) da metabotropic glutamate 2,3 (mGlur 2,3). Koyaya, rawar canje-canje a alamomin alamar damuwa ta glutamatergic akan alamun abinci mai cike da ƙarfin makamashi yayin ci gaba ba a bayyana shi ba. A nan, mun ƙayyade tasirin shirye-shiryen abinci mai gina jiki a lokacin gestation akan zaɓin abincin mai ta amfani da gwajin matsayin fifiko (CPP) da kuma amsawar horo na aiki da tasirin sa ga alamomin glutamatergic a cikin ƙirar nukiliya (Nac) da kwandon prefrontal cortex (PFC). Bayananmu sun nuna cewa berayen sun nuna fifiko ga abincin mai mai da yawa kuma yana ƙaruwa da yawan adadin kuzari idan aka kwatanta da irin abincin da ake ci. Mahimmanci, 74% na berayen da ke nuna fifiko don cin abinci mai ƙiba yana daidaita tare da kyakkyawan sakamako mai haɗin HFD yayin da 26% ya kasa samun yanayin HFD. Hakanan, berayen maza da aka horar a ƙarƙashin jadawalin amsawa na horo na aiki (FR1, FR5 da PR) sun nuna ƙungiyar manyan masu ba da amsa da aiki don abinci. Musamman ma, tsarin abinci mai gina jiki na berayen mata yana haifar da mummunan rauni ga masu karfafawa a cikin zuriyarsu mace idan aka kwatanta da zuriya daga abincin da ake ci. A ƙarshe, mun gano cewa amsawar mai ba da horo ga masu karfafawa mai karfafawa tana da alaƙa da haɓaka mGlur 2,3 a cikin kwalin NAc da PFC na berayen maza da zuriya mata. Hakanan, mun sami maɓallin Nr1 mai zaɓi a cikin harsashi NAc da PFC na zuriya mata. Bayananmu sun ba da shawarar cewa shirye-shiryen abinci mai guba ta hanyar hauhawar ƙwayar cuta yana haifar da motsawa zuwa ga motsa jiki don yin aiki don abinci da maganin canzawar synaptic plasticity a tsarin mesolimbic.
KALMOMI MAI KYAU: Jaraba; Zaɓin wuri mai kyau; Abincin mai mai yawa; Nucleus accumbens; mGlur2,3
PMID: 28487223
DOI: 10.1016/j.bbr.2017.05.014