LITATTAFAI: Nazarin ya samo ƙananan matakan masu karɓar D2 a cikin da'irar sakamako (striatum), wanda ya yi daidai da adadin amfani. Hakanan gano cewa matakan masu karɓa na dopamine sun yi daidai da hypofronatlity.
Hoton Eur J Nucl Med Mol. 2014 Yuli;41(7):1388-97 . doi: 10.1007/s00259-014-2708-8.
Tian M 1 , Chen Q , Zhang Y , Du F , Hou H , Chao F , Zhang H.
Abstract
BACKGROUND:
Rashin caca na yanar gizo matsala ce ta haɓaka a duk duniya, yana haifar da mahimmancin ilimi, zamantakewa, da kuma rashin aiki. Koyaya, hanyar neurobiological na tashin hankali na caca ta yanar gizo ba a sani ba. Manufar wannan binciken ita ce tantance kwakwalwa dopamine D2 (D2) / Serotonin 2A (5-HT2A) aikin mai karɓar jini da haɓaka glucose a cikin waɗannan batutuwa ta hanyar tsarin sarrafa hoto na Pitroron (PET), kuma bincika ko akwai daidaituwa tsakanin mai karɓar D2 da kuma tasirin glucose.
MUTANE:
Ma'aikata na mutum-goma sha biyu masu amfani da kwayoyi marasa lafiya waɗanda suka cika sharudda don rikicewar wasan caca ta yanar gizo da kuma daidaitawar 14 da aka daidaita tare da PET da (11) CN-methylspiperone ((11) C-NMSP) don tantance wadatar D2 / 5-HT2A masu karɓa kuma tare da ( 18) F-fluoro-D-glucose ((18) F-FDG) don tantance tsarin glucose na kwakwalwa na yanki, alama ce ta aikin kwakwalwa. (11) C-NMSP da (18) F-FDG PET bayanan hoto an samu su a cikin waɗannan mutane guda ɗaya a ƙarƙashin ɗayan hutu da kuma ayyukan wasannin intanet.
Sakamakon:
A cikin batutuwan rashin lafiyar caca na intanet, an lura da raguwa mai yawa a cikin glucose metabolism a cikin tsarin farkon, na wucin gadi, da tsarin limbic. An lura da karɓar karɓaɓin masu karɓar D2 a cikin yankin, kuma an haɗa shi zuwa shekaru da aka wuce amfani da shi. Lowarancin masu karɓa na D2 a cikin tasirin yana da alaƙa da raguwar metabolism a cikin ƙwayar orbitofrontal.
TAMBAYOYI:
A karo na farko, muna bayar da rahoton shaidar cewa matakin mai karɓar D2 yana da alaƙa da haɓakar glucose a cikin mutane guda ɗaya tare da rikicewar wasan caca, wanda ke nuna cewa D2 / 5-HT2A mai lalata-matsakaici na diski na orbitofrontal cortex na iya ɗaukar wata hanyar don asara na sarrafawa da halayyar tilastawa a cikin batutuwan caca na intanet.