LITTAFINSA: Nazari kan batutuwan da ke tattare da rashin hankali (jarabar batsa / jima'i) ya ba da rahoton canje-canje na kwayar halitta wanda ke bayyana waɗanda ke faruwa a cikin giya. Canje-canje na epigenetic ya faru ne a cikin kwayoyin halittar da ke da alaƙa da tsarin ƙwaƙwalwar ƙwayar ƙwayar cuta (wanda ke da mahimmanci a cikin ƙauna, haɗin gwiwa, jaraba, damuwa, da dai sauransu). Karin bayanai:
- Jima'i / batsa mai alamomin alamomi don tsarin ƙwaƙwalwar ƙwaƙwalwar kwakwalwa yayi kama da mashaya
- Binciken binciken yayi daidai da Kuhn & Gallinat, 2014 (sanannen binciken FMRI akan masu amfani da batsa)
- Nemo yana iya nuna tsarin damuwa na damuwa (wanda shine maɓallin canji a cikin jaraba)
- Canji a cikin kwayoyin oxygentocin na iya shafan ɗaurin aure, damuwa, aikin jima'i, da sauransu.
Don ƙarin, karanta wannan batun fasaha mai faɗi: Masana kimiyya sun gano yiwuwar hormone mai alaƙa da rikicewar hyperexual
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Adrian E. Boström, Andreas Chatzittofis, Diana-Maria Ciuculete, John N. Flanagan, Regina Krattinger, Marcus Bandstein, Jessica Mwinyi, Gerd A. Kullak-Ublick, Katarina Görts Öberg, Stefan Arver, Helgi B. Schiöth & Jussi Jokinen (2019) )
Epigenetics, DOI: https://doi.org/10.1080/15592294.2019.1656157
Abstract
An gabatar da rikicewar hypersexual (HD) azaman bincike a cikin DSM-5 kuma yanzu an gabatar da matsayin 'Rashin halayen Jima'i' a matsayin cuta mai rikicewa a cikin ICD-11. HD ya haɗu da nau'ikan ƙwayoyin cuta; gami da tursasawa, tilastawa, sha'awar jima'i da jarabar jima'i. Babu wani binciken da ya gabata wanda yayi bincike HD a cikin nazarin methylation wanda aka iyakance zuwa microRNA (miRNA) shafukan yanar gizon CpG. An auna tsarin methylation na genome a cikin jini gabaɗaya daga batutuwa na 60 tare da HD da masu ba da lafiya masu lafiya na 33 suna amfani da Illumina EPIC BeadChip. An bincika wuraren haɗin CpG-8,852 na CpG-shafuka masu yawa a cikin ƙididdigar rikice-rikicen rikice-rikice na methylation M-dabi'u zuwa yanayin sassaucin ra'ayi na binary na cutar cuta (HD ko masu sa kai na lafiya), daidaitawa don kyakkyawan shawarar covariates. An bincika matakan bayyanar miRNAs ɗan takarar a cikin mutane guda ɗaya don bambance bambance na magana. An kara nazarin ɗan takarar methylation loci don haɗuwa tare da dogara da giya a cikin rukunin masu zaman kansu na batutuwa na 107. CpG-shafuka biyu sun kasance masu mahimmancin iyaka a HD - cg18222192 (MIR708) (p <10E-05,pFDR = 5.81E-02) da cg01299774 (MIR4456) (p <10E-06, pFDR = 5.81E-02). MIR4456 ya ragu ƙwarai da aka bayyana a cikin HD a cikin duka nau'ikan (p <0.0001) da multivariate (p <0.05) na nazari. Cg01299774 matakan methylation sun kasance daidai da alaƙa tare da matakan magana na MIR4456 (p <0.01) kuma an haɗa su daban-daban a cikin maye gurbin (p = 0.026). Tsarin hangen nesa na Gene da kuma nazarin hanyar da aka gano sun nuna cewa MIR4456 yana sa ido kan ƙwayoyin halittar da aka fi so a cikin kwakwalwa kuma waɗanda ke cikin manyan ƙwayoyin ƙwayoyin cuta waɗanda ake zaton sun dace da HD, misali, hanyar siginar oxytocin. A taƙaice, bincikenmu yana nuna gudummawar MIR4456 a cikin ilimin halittar jiki ta HD ta hanyar tasiri tasirin siginar oxytocin.
DAGA ZAUREN FIQHU
A cikin bincike na haɗin methylation na DNA a cikin jini na yanki, muna gano takamaiman CpG-shafukan da ke da alaƙa da MIR708 da MIR4456 waɗanda ke da bambanci sosai a cikin marasa lafiya na HD. Bugu da ƙari, muna nuna cewa hsamiR-4456 hade da methylation locus cg01299774 an bambanta methylated a cikin dogara da barasa, yana ba da shawara cewa ana iya haɗa shi da farko tare da kayan maye wanda aka lura a HD.
Zuwa ga iliminmu, babu takarda da ta gabata ta bayyana mahimmancin MIR4456 a cikin yanayin mahallin psychopathologies. Mun gano cewa wannan miRNA an kiyaye shi akan juyin halitta dangane da abubuwan da aka tsara na farko da kuma tsinkayar tsinkayukan shunn gashi daga farkon farkon. Bugu da kari, muna ba da hujjoji da ke nuna cewa burin MRNA na MIR4456 shine wanda aka zazzage a amygdala da hippocampus, yankuna kwakwalwa guda biyu da Kühn et al suka ba da shawara. da za a iya amfani da shi a cikin pathophysiology na HD [5].
Kasancewar hanyar siginar oxygentocin da aka bayyana a cikin wannan binciken yana nuna alama yana da tasiri sosai a cikin yawancin halayen dake nuna HD kamar yadda Kafka et al suka gabatar. [1], kamar sha'awar jima'i, lalata, sha'awar sha'awa da (jima'i). Mafi yawan abubuwan da ke gudana a cikin kwayar halitta na hypothalamus kuma aka saki ta hanyar pituitary na baya, oxytocin yana taka muhimmiyar rawa a cikin haɗin zamantakewar jama'a da haifuwa ta jima'i a cikin maza da mata [59]. Murphy et al. aka bayyana matakan haɓaka yayin tashin hankalin jima'i [60]. Burri et al. gano cewa aikace-aikacen oxygentocin intranasal a cikin maza ya haifar da karuwa a cikin matakan plasma na epinephrine yayin aikin jima'i da kuma canza tsinkaye game da tashin hankali [61]. Bugu da ƙari, an ba da shawarar oxytocin don hana ayyukan ƙwayar hypothalamic-pituitary-adrenal (HPA) yayin damuwa. Jurek et al. lura cewa ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta na oxygentocin sun dakatar da fassarar abubuwan da ke ciki na sakin corticotropin (Crf) a cikin ƙwaƙwalwar ƙwaƙwalwa, ƙwaƙwalwar ajiya mai ƙarfi da ke da alaƙa da damuwa na damuwa [62].
Canje-canje a cikin hanyar siginar oxygentocin na iya yin bayanin binciken ta hanyar Chatzittofis et al., Wanda ya lura da lalatawar ƙwayar cuta ta HPA a cikin maza masu rashin lafiyar hypersexual [3]. Bugu da ƙari, bincike ya nuna cewa ana iya shiga cikin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta a cikin ƙwayar cuta na ƙwayar cuta na damuwa [63]. Yin hulɗa da oxygentocin tare da tsarin dopamine, ƙwaƙwalwar HPA-da tsarin rigakafi ya haifar da rikicewar cewa bambance-bambancen mutum a cikin matakan oxygentocin suna haifar da raunin tashin hankali [64]. Duk da yake ana amfani da oxygentocin a baya tare da ka'idar halayen zamantakewa da tashin hankali, Johansson et al. kara nuna cewa bambancin kwayoyin halitta a cikin kwayoyin karɓa na oxygentocin (OXTR) yana tasiri akan sha'awar amsawa ga yanayi tare da matakan fushi a ƙarƙashin tasirin barasa [65]. A ƙarshe, Brüne et al. kammala cewa bambancin kwayar halitta a cikin OXTR na iya ba da gudummawa ga yin bayanin pathophysiology na rashin daidaituwa game da iyakoki [66], yanayin halayyar mutum wanda aka san shi da mummunan lalacewa na dysregulation [66].
MIR4456may suna da ƙarin aikin iko a cikin HD wanda ba a bayyana shi ba a cikin binciken na yanzu. A layi tare da bincikenmu, binciken da ya gabata sun ba da rahoton ƙungiyoyi na halayen jima'i na maza da ke da alaƙa da tsarin glutamatergic a cikin mutane masu ɓacin rai [67]. Bugu da ƙari kuma, rawar da za a iya amfani da ita na matakan Xennen '3ʹ-cyclic adenosine mono phosphate (cAMP)' a cikin karɓar jima'i a cikin berayen mata, ta hanyar gyaran phosphoprotein-5 kuma yana haifar da sauye-sauyen masu karɓar progestin [32]. Abin sha'awa, CAMP kuma yana daidaita kwayoyin da ke da alaƙa da jagoranci na axon [68], kamar su ƙirar B69gnt3, wanda aka danganta shi da halayen jima'i mara kyau a cikin mice na maza
SHAWARA NA FARKO Game da karatun:
Masana kimiyya sun gano yiwuwar hormone mai alaƙa da rikicewar hyperexual
Wani sabon nazari na maza da mata masu fama da rashin hankali ya bayyana yiwuwar halayen oxygentocin, bisa ga sakamakon da aka buga a mujallar. Epigenetics. Samun binciken na iya buɗe ƙofar don magance cutar ta hanyar injiniya hanyar da za a iya dakatar da ayyukan ta.
Rashin hankalin mahaifa, ko kuma motsawar jima'i, ana gane shi azaman rashin lafiyar jima'i, wanda aka jera azaman lalacewar sarrafawa ta byungiyar Lafiya ta Duniya. Ana iya bayyaninsa ta hanyar tunani mai ma'ana game da jima'i, tilasta yin ayyukan jima'i, asarar iko, ko halayen jima'i waɗanda ke ɗauke da matsaloli masu haɗari ko haɗari. Yayinda ƙididdigar yawanci ya bambanta, wallafe-wallafen sun nuna cewa rikicewar hypersexual yana shafar 3-6% na yawan jama'a.
Jayayya ta kewayewa game da ganewar asali saboda yawanci yakan faru tare da wasu batutuwa na rashin lafiyar kwakwalwa, yana ba da shawara na iya zama faɗaɗa ko kuma nuna rashin lafiyar kwakwalwa. Karancin sani game da ilimin halittar jini a bayansa.
"Mun tashi ne don binciko hanyoyin gudanar da tsarin halittar halittar da ke haifar da matsalar lalata da mata don haka za mu iya tantance ko tana da wasu alamomi da za su bambanta ta da sauran al'amuran kiwon lafiya," in ji marubucin marubucin Adrian Boström daga Sashen Nazarin Neuroscience na Jami'ar Uppsala, Sweden wanda ya gudanar da aikin karatu tare da masu bincike daga fromungiyar Magungunan Magungunan Andrology / Jima'i (ANOVA) a Karolinska Institutet, Stockholm, Sweden.
"A iliminmu, bincikenmu shi ne na farko da zai iya haifar da tsarin halittar halittar mutum ta hanyar yaduwar halittar DNA da aikin microRNA da kuma shigar da sinadarin oxytocin a cikin kwakwalwa tsakanin marasa lafiya da ke neman magani don luwadi da madigo."
Masana kimiyyar sun auna tsarin methylation na DNA a cikin jini daga masu cutar 60 da ke fama da matsalar rashin kwanciyar hankali da kuma kwatanta su zuwa samfurori daga masu ba da agaji na lafiya na 33.
Sun bincika yankuna na 8,852 na methylation na DNA da ke hade da microRNAs na kusa don gano kowane bambanci tsakanin samfurori. DNA methylation na iya shafar bayanin magana da aikin kwayoyin, yawanci suna aiki don rage ayyukansu. Inda aka gano canje-canje a cikin ƙwayar methylation na DNA, masu binciken sun bincika matakan kyautar asalin kwayoyin microRNA da ke hade. MicroRNAs suna da ban sha'awa musamman saboda suna iya wuce katange-kwakwalwa-kwakwalwa da daidaita ko lalata yanayin kimar kwayoyin halittu da dama daban-daban a cikin kwakwalwa da sauran kyallen takarda.
Sun kuma kwatanta abubuwan da suka gano zuwa samfurori daga batutuwa na 107, 24 waɗanda suke dogaro da barasa, don bincika haɗin gwiwa tare da halayen jaraba.
Sakamakon binciken ya gano yankuna biyu na DNA waɗanda aka canza a cikin marasa lafiyar rashin lafiyar. Aiki na yau da kullun na DNA methylation ya lalace kuma an haɗa microRNA, wanda ke da hannu a cikin rufewa cikin gene, an gano cewa ba a bayyana shi ba. Bincike ya nuna cewa microRNA da aka gano, microRNA-4456, yana lalata kwayoyin halittar da aka bayyana a koyaushe musamman matakan girma a cikin kwakwalwa kuma waɗanda ke da hannu cikin ka'idar oxygentocin hormone. Tare da ragewa ta hanyar rage girman kwayoyin, ana iya tsammanin oxygentocin ya kasance a cikin matakan da ke sama, kodayake binciken na yanzu bai tabbatar da wannan ba.
An gan shi a takamaiman sanannu da nau'in asali na neuropeptide oxytocin yana taka rawa ta tsakiya a cikin ka'idar halayen haɗin gwiwa. Nazarin da suka gabata sun nuna cewa oxytocin yana da alaƙa da tsarin zamantakewa da haɗin gwiwa, haifuwa ta jima'i da halayyar tashin hankali a cikin maza da mata. Idan aka kwatanta shi da batutuwan da suka dogara da barasa sun bayyanar da yankin na DNA guda ɗaya don zama mai zurfin tunani, yana ba da shawara cewa yana iya kasancewa da alaƙa da abubuwan da ke tattare da cututuka na tashin hankali, irin su jarabar jima'i, sha'awar jima'i, lalata sha'awa da kuma sha'awar rayuwa.
"Za a buƙaci ƙarin bincike don bincika rawar microRNA-4456 da oxytocin a cikin rikicewar jima'i, amma sakamakonmu yana nuna cewa zai iya zama da amfani mu bincika fa'idodi da ƙwayoyi da hauka don rage ayyukan oxytocin," in ji Farfesa Jussi Jokinen daga Umeå Jami'ar, Sweden.
Marubutan sun lura cewa iyakancewar binciken shine cewa bambanci mai ma'ana a cikin methylation na DNA tsakanin marasa lafiyar hypersexual cuta da masu ba da agaji na lafiya sun kasance kusa da 2.6%, don haka ana iya kiran tasirin canje-canje kan canje-canje a cikin tambaya. Koyaya, jiki mai ba da shawara na abubuwanda ke nuna cewa kawai canje-canje na methylation na iya samun sakamako mai yawa ga mawuyacin yanayi irin su bacin rai ko schizophrenia.
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An gudanar da binciken ne ta hanyar yarjejeniya ta yanki tsakanin jami’ar Ume and da Västerbotten County Council (ALF) da kuma taimakon tallafin da Majalisar Ma’aikata ta Stockholm ta bayar, da Gidauniyar Binciken Sweden, da Gidauniyar Åhlens, da Gidauniyar Novo Nordisk, da Cibiyar Bincike na Brain Sweden Gidauniyar.
SASHE NA BIYU dangane da karatun:
Canje-canje na Epigenetic ya danganta da Rashin Tsarin Magana da Halayyar icara
Tattaunawa da MedicalResearch.com tare da: Adrian E. Boström MD, a madadin marubutan
Ma'aikatar Neuroscience, Uppsala University, Sweden
MedicalResearch.com: Menene tushen wannan binciken?
Amsar: Yayinda ƙididdigar yawanci ya bambanta, wallafe-wallafen sun nuna cewa rashin lafiyar hyperexual (HD) yana shafar 3-6% na yawan jama'a. Koyaya, rikice-rikice ya kewaye bayyanar cutar kuma ba a san komai game da ilimin halittar neurobiology a bayan sa.
Ba a bincika rikicewar rikicewar jima'i a baya game da asalin halittu da rubuce-rubuce a cikin tsarin binciken ba da kyauta ba kuma ba a san komai game da kwayar cutar da ke tattare da wannan matsalar. Mun bincika ko akwai wasu canje-canje na asali waɗanda suka shafi tasirin kwayar halitta da magana a cikin marasa lafiyar maza da mata (HD) kuma mun gano microRNA mai ɓarna wanda aka yi imanin zai iya tasiri ga tsarin aikin tasirin kwayar cutar oxytocin a cikin kwakwalwa.
Oxytocin sananne ne yana da tasirin tasirin halaye masu yawa. A mafi kyawun iliminmu, babu wani binciken da ya gabata wanda aka ba da hujja don haɗuwa tsakanin DNA methylation, aikin microRNA da oxytocin a cikin rikicewar jima'i. Abubuwan da muka gano sun cancanci ci gaba da bincike a cikin rawar MIR4456 kuma musamman Oxytocin a cikin rikicewar jima'i. Ana buƙatar ƙarin nazarin don tabbatar da rawar Oxytocin a cikin HD da kuma bincika ko magani tare da maganin ƙwayoyin maganin ƙwaƙwalwar ƙwayar cuta zai iya samun sakamako mai amfani ga marasa lafiya da ke fama da rikicewar jima'i.
MedicalResearch.com: Menene ainihin binciken?
Amsar: - A cikin wannan binciken munyi bincike game da 8000 daban-daban methylation DNA an tsara shi ta hanyar maganganun rashin kyautawa kuma hakan bai dace ba. Saboda haka, munyi mamaki da mamakin gano wani karfi mai lalata microRNA wanda yake nuna kwayar halitta da farko aka bayyana a kwakwalwa kuma wannan yana da hannu a cikin manyan hanyoyin kwayoyin halittar da ake tunanin zasu dace da rashin lafiyar cuta, misali hanyar tafi da siginar oxygentocin. Wannan microRNA shima ya bayyana ne kamar yadda aka kiyaye masanan a duk lokacin mulkin mallaka, wanda kuma abune mai ban sha'awa da bazata.
MedicalResearch.com: Me ya kamata masu karatu su nisanta daga rahotonku?
Amsar: Rashin hankali na rashin hankali ya haɗa da hanyoyi daban-daban na cututtukan cututtukan ciki har da rashin ƙarfi, tilastawa, lalata sha'awar jima'i da jarabar jima'i. Ana iya fassara wannan don wannan cuta ta rashin hankali ya ƙunshi abubuwa masu maye, amma ba za a gan shi azaman jaraba kawai ba. Abubuwan da muka samo, a cikin hasken crossover tare da dogara da barasa, suna ba da shawarar cewa MIR4456 da hanyar siginar oxygentocin na iya kasancewa da farko tare da abubuwan da ke kara kuzari na rashin damuwa. Ana buƙatar ƙarin nazarin don tabbatar da wannan.
MedicalResearch.com: Wadanne shawarwari kuke da su don bincike na gaba sakamakon wannan aikin?
Amsar: Sakamakonmu yana motsa ƙarin bincike a cikin inganci na, misali, oxytocin yana tsara maganin miyagun ƙwayoyi a cikin rikicewar jima'i wanda zai iya ba da gudummawa ga zaɓuɓɓukan magani na zamani don inganta sakamakon asibiti na waɗanda abin ya shafa. Bugu da ƙari, muna gano takamaiman microRNA (miRNA) wanda za'a iya gwada kwayoyi masu daidaita miRNA na gaba a cikin rikicewar rikici tsakanin maza da mata.
MedicalResearch.com: Shin akwai wani abu da kuke son ƙarawa?
Amsar: DNA din mu lambar kwayar halitta ce wacce take fassarawa zuwa jerin amino acid da ake kira sunadarai. Hakanan, sunadarai, sune babban mahimman ma'anar dukkanin rayayyun halittu. DNA dinmu na gado ne kuma baya canzawa akan lokaci. Wannan binciken, duk da haka, yana da alaƙa da asalin halittar mutum, waɗanda canje-canje ne da suka shafi tasirin kwayar halitta da bayyanawa. Waɗannan ayyukan asalin halitta suna canzawa akan lokaci kuma ana iya lalata su cikin wasu cututtuka. Akwai hanyoyi daban-daban na asali.
A cikin wannan binciken, munyi nazarin methylation na DNA (tsarin da aka sani don tasiri tasirin magana, ma'ana, yawan kwayar halittar da aka fassara ta cikin furotin) da aikin microRNA (gajerun sassan halittu marasa kode wadanda zasu iya tasiri kan fassarar ɗari da yawa kwayoyin daban-daban).
Kwatanta marasa lafiya tare da rikicewar rikici tsakanin maza da mata da masu aikin sa kai na lafiya, mun gano jerin methylation na DNA don canzawa sosai a cikin rikicewar jima'i. Don tabbatar da mahimmancin wannan binciken, an ƙara nuna jerin DNA iri ɗaya don zama mai lalata a cikin batutuwa da ke dogaro da barasa, yana ba da shawarar cewa zai iya kasancewa da farko haɗuwa da ɓangaren jaraba na rikicewar jima'i. Tsarin methylation na DNA da aka gano yana da alaƙa da microRNA da ake kira (microRNA 4456; MIR4456), kuma ƙarin bincike ya nuna cewa wannan jerin methylation ɗin DNA yana tasiri yawan MIR4456 da aka samar. Bugu da ƙari kuma, a cikin ƙungiyar binciken guda ɗaya, muna nuna cewa MIR4456 yana cikin ƙananan ƙananan cuta a cikin rikicewar rikicewar jima'i idan aka kwatanta da masu sa kai na lafiya, suna ba da shawara mai ƙarfi cewa canza tsarin methylation na DNA a cikin tasirin rikicewar mata da kuma bayar da gudummawa wajen bayanin abin da aka gano na dysregulation na MIR4456. Kamar yadda microRNA: a bisa ka'ida suna iya hango wasu nau'ikan kwayoyin halittu daban-daban, munyi amfani da algorithms na kwamfuta don bayyana cewa MIR4456 yana niyya ne ga kwayoyin halittar da ake nuna su a kwakwalwa kuma wadanda suke da hannu a cikin manyan kwayoyin kwayoyin halittar da ake zaton zasu dace da HD, misali, the oxytocin hanyar sigina. Abubuwan da muka gano sun cancanci ci gaba da bincike a cikin rawar MIR4456 kuma musamman Oxytocin a cikin rikicewar jima'i. Ana buƙatar ƙarin nazarin don tabbatar da rawar Oxytocin a cikin HD da kuma bincika ko magani tare da maganin ƙwayoyin maganin ƙwaƙwalwar ƙwayar cuta zai iya samun sakamako mai amfani ga marasa lafiya da ke fama da rikicewar jima'i.
Duk da haka bayanan da ba a buga ba wanda aka tsara don nazarin binciken na daban ya nuna ƙaruwa sosai a cikin matakan Oxytocin a cikin marasa lafiya da ke fama da larurar maza da mata idan aka kwatanta da sarrafawa, da kuma raguwa mai yawa a matakan oxytocin bayan maganin Fahimtar havabi'ar gnabi'a, wanda ke nuna mahimmancin rawar Oxytocin a cikin rashin daidaituwa tsakanin maza da mata da yin da'awar da aka gabatar a cikin wannan binciken da ƙarfi sosai. An gabatar da waɗannan sakamakon farko a matsayin ƙarshen rubutun ƙarshe a cikin ofungiyar Sadarwar logicalabi'a a watan Mayu 2019 kuma an gabatar da su azaman bugawa a cikin ACNP a watan Disamba na 2019.
Kira:
Adrian E. Boström et al, Rage rikicewar hypermethylation na lalacewa na microRNA-4456 a cikin rikicewar hypersexual tare da tasirin putative akan siginar oxygentocin: Binciken methylation na DNA na kwayoyin halittar miRNA, Epigenetics (2019). DOI: 10.1080 / 15592294.2019.1656157
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