Bayanan kwayoyin halitta na nuna taba taba taba shan taba yana shafar ilmin halayen kwakwalwa
Yuni 6th, 2011 a Neuroscience
Tabbataccen tabbaci na mummunar tasirin amfani da marijuana na yau da kullun wanda aka bayyana a taron 58 na shekara na SNM na iya haifar da maganin magunguna da taimakon wasu bincike da ke tattare da masu karɓar Cannabinoid, tsarin karɓar bautar da ke karɓar hankali sosai. Masana kimiyya sunyi amfani da hoton kwayoyin don hango canje-canje a kwakwalwar masu shan tabar wiwi da wadanda ba masu shan sigari ba kuma sun gano cewa shan kwaya ya haifar da raguwar masu karba na CB1 na cannabinoid, wanda ke da hannu ba kawai jin daɗi, ci da haƙuri ba amma mahaukaci na sauran ayyukan halayyar mutum da tunani.
"Addications babbar matsala ce ta likitanci da tattalin arziki," in ji Jussi Hirvonen, MD, PhD, marubucin marubucin binciken haɗin gwiwa tsakanin Cibiyar Kula da Lafiya ta Hauka da Cibiyar Nazarin Magunguna ta ,asa, Bethesda, Md. "Abin takaici, ba mu cika cika ba fahimci abubuwan da ke tattare da kwayar cutar da ke tattare da jaraba. Tare da wannan binciken, mun sami damar nunawa a karo na farko cewa mutanen da ke cin zarafin wiwi suna da haɗari na masu karɓar Cannabinoid a cikin kwakwalwa. Wannan bayanin na iya tabbatar da mahimmanci ga ci gaban maganin gargajiya na cin zarafin wiwi. Bugu da ƙari kuma, wannan binciken ya nuna cewa raguwar masu karɓar maganin a cikin mutanen da ke shan tabar wiwi sun dawo yadda suke yayin da suka daina shan ƙwaya. ”
Bisa ga Cibiyar Nazarin Kasuwancin Kwayoyi ta Drug, marijuana ita ce magungunan miyagun ƙwayoyi marasa amfani a Amirka. Kwayar motsa jiki a cikin marijuana, ko cannabis, ita ce delta-9-tetrahydrocannabinol (THC), wadda ke ɗaure ga masu karɓa na cannabinoid a cikin kwakwalwa da kuma cikin jiki lokacin da aka kyafaffen ko amfani da su, suna samar da wani abu mai mahimmanci. Ma'aikata na Cannabinoid a cikin kwakwalwa suna tasiri ga jinsin jihohi da kuma ayyuka, ciki har da farin ciki, ƙaddarawa, fahimtar lokaci da ƙwaƙwalwar ajiya, fahimta mai mahimmanci, da kuma daidaitawar motsi. Har ila yau akwai masu karɓa na cannabinoid a cikin jikin da ke cikin tasiri masu yawa na kwayoyin cutar, da na zuciya, da na numfashi da kuma sauran tsarin jiki. A halin yanzu ana iya sanin kashi biyu daga cikin masu karɓa na cannabinoid, CB1 da CB2, wanda ya kasance mafi girma a cikin ayyukan tsakiya na tsakiya da kuma na ƙarshe a cikin tsarin tsarin rigakafi da kuma cikin kwayoyin halitta na tsarin sigina.
Don wannan binciken, masu bincike sun karbi 30 masu shan taba na yau da kullum wanda ake kula da su a asibiti a kusan mako hudu. An horar da wadannan batutuwa ta hanyar yin amfani da hoton kwaikwayon katako (PET), wanda ke ba da bayani game da tafiyar da ilimin lissafin jiki a jiki. An kwantar da su tare da radioligand, 18F-FMPEP-d2, wanda ke hade da isotope fluorine da kuma analog neurotransmitter wanda ke ɗaukar masu karɓar kwakwalwa na CB1.
Sakamakon binciken ya nuna cewa an rage yawan adadin mai karɓar nau'in 20 a ƙwararrun masu shan taba a cannabis idan aka kwatanta da ka'idodin kula da lafiyar da ke da iyakancewa ga cannabis a lokacin rayuwarsu. Wadannan canje-canjen an samo su da dangantaka tare da shekaru masu yawa batutuwa sun sha taba. Daga ainihin 30 masu shan taba taba, 14 daga cikin batutuwa sunyi amfani da PET na biyu bayan kimanin watanni na abstinence. Akwai karuwa mai karuwa a cikin ayyukan sakonni a waɗancan yankunan da aka rage a farkon binciken, nuna cewa yayin da shan taba na taba na shan taba yana haifar da lalatawa na masu sauraron CB1, lalacewa yana iya canzawa tare da abstinence.
Bayanan da suka karɓa daga wannan kuma nazarin na gaba zai iya taimakawa wasu bincike da yayi nazarin muhimmancin PET game da kamfanonin CB1-ba kawai don amfani da miyagun ƙwayoyi ba, har ma ga cututtuka na cututtuka na mutum, ciki har da cutar da cutar da ciwon daji.
Informationarin bayani: Takaddun Kimiyyar 10: J. Hirvonen, R. Goodwin, C. Li1, G. Terry, S. Zoghbi, C Morse, V. Pike, N. Volkow, M. Huestis, R. Innis, National Institute of Mental Lafiya, Bethesda, MD; Cibiyar Nazarin Magunguna ta Kasa, Baltimore, MD; "Sauye-sauye da zaɓin yanki na kwakwalwa Cannabinoid masu karɓar CB1 a cikin masu shan sigari na yau da kullun," Taron taron shekara na SNM na 58, 4-8 ga Yuni, 2011, San Antonio, TX.
Kamfanin Society of Medicine Nuclear
Bayanan kwayoyin halitta na nuna taba taba taba shan taba yana shafar ilmin halayen kwakwalwa.
;
