Gary cov lus:
- Rau erections, txawv dopamine receptors yog qhib (nrog cov oxytocin txawv thaj tsam) nyob ntawm saib seb tus poj niam kws tuaj txuam nrog los yog tsis yog. Yuav txhais tau tias tus kheej stimulation sib txawv los ntawm tus khub stimulation - nyob rau hauv cov cheeb tsam oxytocin yog qhib kom ua.
- Txoj kev tshawb no qhia tias oxytocin-tsim hlwb muaj cov dopamine receptors. Yog li dopamine ua kom muaj zog hauv oxytocin.
Baskerville TA, Allard J, Wayman C, Douglas AJ.
Eur J Neurosci. 2009 Dec 3; 30 (11): 2151-64. Epub 2009 Nov 25.
Center for Integrative Physiology, Lub Tsev Kawm Ntawv ntawm Biomedical Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.
Dopamine thiab oxytocin tau tsim cov cwj pwm nyob hauv cov kev tswj hwm hauv kev ua haujlwm ntawm cov pob qij txha hauv cov nas; Txawm li cas los xij, lub neural circuitries tau koom tes hauv cov ntsiab lus meej erectile thiab kev sib cuam tshuam ntawm dopamine thiab oxytocin mechanisms nyob twj ywm yuav tsum tau elucidated.
Hypothalamus thaj chaw nruab nrab ntawm cev (MPOA), supraoptic nucleus (SON) thiab paraventricular nucleus (PVN) ntawm hypothalamus tuaj yeem yog qhov chaw sib tw vim lawv muaj oxytocin hlwb, tau txais dopaminergic inputs thiab tau muaj kev cuam tshuam nrog kev sib deev txiv neej tus cwj pwm.
Ob zaug immunofluorescence tau qhia tias muaj ntau yam ntawm cov kabmob oxytocin hauv MPOA, SON thiab PVN muaj dopamine D (2), D (3) thiab D (4) cov neeg tuaj yeem.
Hauv kev siv lub pob tsuag, siv cov pob tshab hauv kev siv ua lub luag hauj lwm ntawm lub cev, ntawm blockade ntawm lumbosacral oxytocin receptors (UK, 427843) txo cov lus teb rau cov pob txha dopamine agonist (apomorphine), qhia tias dopamine recruits paraventriculospinal oxytocin txoj kev.
Hauv cov txiv neej tsis meej pem thaum tsis muaj poj niam, kev siv tshuaj tiv thaiv los ntawm D (2) / D (3) (Quinelorane) tiam sis tsis D (4) (PD168077) agonist tau txuam nrog kev ua ntawm cov hlwb parvocellular PVN oxytocin hlwb.
Hauv ib qho kev sim lwm tus txiv neej tau muab tag nrho cov poj niam hauv tsev, tus D (4) (L-745870) tiam sis tsis D (2) los yog D (3) antagonist (L-741626; nafadotride) inhibited penile erection (intrusion) thiab qhov no tau txuas nrog SON magnocellular oxytocin neuron ua kom.
Ua ke, cov ntaub ntawv qhia dopamine cov teebmeem ntawm hypothalamic oxytocin hlwb thaum rab qau erection yog cov ntsiab lus tseeb.
Dopamine tuaj yeem ua tau ntawm kev sib txawv ntawm parvocellular thiab magnocellular oxytocin subpopulations rau cov lus teb rau erectile, nyob ntawm seb puas muaj kev cuam tshuam.
Txoj kev tshawb no ua rau pom muaj peev xwm ntawm kev sib koom nruab nrab ntawm central dopamine thiab oxytocin txoj kev thaum lub sij hawm penile erection, nrog SON thiab PVN pab raws li qhov chaw nruab nrab.
;