Cov lus hais: Dopamine agonist (mimics dopamine) pab txo kev ntxhov siab.
J Psychopharmacol. 2008 Oct 6;
Hood S, Potokar J, Davies S, Hince D, Morris K, Seddon K, Nutt D, Argyropoulos S.
Psychopharmacology Unit, Dorothy Hodgkin Tsev, Bristol, UK; Lub Tsev Kawm Ntawv ntawm Psychiatry thiab Clinical Neurosciences (M521), University of Western Australia, Perth, Australia.
Abstract
Serotonergic antidepressants (SSRIs) yog cov kev kho thawj zaug rau kev ntxhov siab vim muaj kev ntxhov siab [SAnD], tab sis yog muaj pov thawj ntawm qhov mob dopaminergic system kawg.
Nees nkaum lub hnub nyoog nrog DSM-IV SAnD, tsis kho (n = 10) thiab SSRI-remitted DSM-IV SAnD (n = 10), tau txhaj ib koob ntawm 1) ib dopamine agonist (pramipexole 0.5 mg) thiab 2) dopamine antagonist (sulpiride 400 mg), ua raws li kev nyuaj siab ntxhov plawv (lus ua hauj lwm thiab ntawv sau ntawv) hauv qhov kev sib tw ob chav dig muag, ob hnub xeem ntawv yog ib lim tiam.
Kev ntxhov siab vim cov tsos mob tau raug ntsuas los ntawm kev ntsuas tus kheej ntawm kev pom hauv Kev Ntsig Txog Kev Ntsuas Kev Hloov, kev meej pob ntseg thiab ntxhov siab. Plasma theem ntawm prolactin tau. Cov neeg tsis muaj mob uas tsis tau kho tau pom muaj cov tsos mob ntawm kev ntxhov siab ntau dua li cov kev cov nyom tom qab ntawm tus mob sulpiride lossis pramipexole.
Tom qab ua tiav nrog SSRIs, qhov kev ntxhov siab ntawm kev phem ntawm kev coj tus cwj pwm tsis txuam raws li dopamine agonist pramipexole, whereas nyob rau hauv cov teebmeem sulpiride yuav ua kom siab. Muaj tshwm sim tsis tshua muaj kev dopamine nyob rau hauv kev coj tus cwj pwm kev ntxhov siab nyob rau hauv kev ntxhov siab yam uas tsuas yog qee qhov rectified los ntawm kev kho mob zoo nrog SSRI, uas tej zaum yuav ua rau lub qhov kev qog ntawm cov qog tshuaj DYNUMX DDNUMX dopamine indensitisation.
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