YBOP Cov Lus Pom: Cov qib qis ntawm dopamine receptors (D2) cuam tshuam nrog kev cuam tshuam hauv zej zog. Ntau tus neeg siv porn hnyav tau ntsib kev ntxhov siab. Qee tus tshaj tawm txog kev nce hauv kev txhawj xeeb hauv zej zog tom qab porn binge. Txog rau qhov kev ntxhov siab feem ntau txhim kho tom qab kev yoo ncua - rau qee lub sijhawm luv luv, lwm tus siv sijhawm ntev dua. Nco ntsoov tias kev tshaj tawm dhau los (quav ntxiv) ua rau muaj kev txo qis dopamine D2 receptors. Nco tseg: Kuv tsis tau hais tias porn ua rau txhua tus mob ntawm SAD.
Kuv J Psychiatry. 2000 Mar;157(3):457-9.
Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M. Kev ntxhov siab vim lub tsev kho mob thiab Lub Hlwb Kev Sib Hlwb, New York State Psychiatric Institute, New York 10032, USA.
YUAV TSUM TAU: Qhov kev tshawb fawb no piv rau dopamine D (2) receptor kev ruaj ntseg muaj peev xwm rau cov neeg mob uas muaj kev phobia thiab kev sib piv zoo.
KEV HLOOV: Dopamine D (2) receptor los ntawm kev sib tw muaj peev xwm soj ntsuam nyob rau hauv 10 unmaticated subjects nrog general social phobia thiab tsis tseem ceeb lub neej psychiatric comorbidity thiab 10 kev sib piv uas zoo sib xws rau cov hnub nyoog thiab kev sib deev. Teeb meem muaj peev xwm raug ntsuas nyob rau hauv qhov kev siv los ntawm kev siv tib lub photon emission computer tom tom qab thiab qhov infusion ntawm D (2) receptor radiotracer [(123) I] iodobenzamide ([123] I] IBZM).
COV LUS QHIA: Txhais tau D (2) receptor binding potential yog ho qis dua hauv kev kawm nrog kev phobia dua li hauv kev sib piv. Hauv cov pawg neeg phobia, muaj ib qho sib txawv ntawm kev sib raug zoo ntawm qhov kev sib tw nrog Liebowitz Social Anxiety Scale tau.
TXHEEJ XWM: Kev koom nrog kev phobia feem ntau yuav ua rau tsis muaj kev sib txuam ntawm [(123) I] IBZM rau D (2) receptors nyob rau hauv kev txheeb ze.
Intro
Qhov kev hloov qee zaum ntawm kev phobia, kev ntshai los ntawm kev ntshai thiab / los yog kev zam ntawm feem ntau ntawm kev sib raug zoo, yog qhov ntev (1), yog heritable (2), thiab muaj peev xwm faib cov cwj pwm coj zoo nrog rau kev sib raug zoo hauv cov tsiaj (3), tseem biology ntawm kev phobia tau me ntsis kawm. Cov ntaub ntawv pov thawj rau kev koom nrog kev phobia nrog kev sib kis hauv cov kab mob dopamine nrog rau kev kho mob rau cov tshuaj monoamine oxidase tab sis tsis yog tshuaj tua kab mob tricyclic antidepressants (4), tsis tshua muaj dopamine transporter ceev hauv kev phob thoob plaws kev noj haus (5), tsawg CSF theem ntawm homovanillic acid ntawm cov tsiv siab tsis tshua mob cov neeg mob nrog kev phob leeg (6), tus nqi siab ntawm kev phobia ntawm cov neeg mob nrog Parkinson tus kab mob (7), thiab muaj zog cov tsos mob phobia thaum lub sijhawm siv tshuaj kho mob ntawm cov neeg mob Tourette's syndrome (8).
Nyob rau hauv txoj kev tshawb no peb piv dopamine D2 tus neeg tuaj yeem txais kev pabcuam hauv cov neeg mob uas muaj kev sib raug zoo phobia thiab kev sib piv nrog kev noj qab haus huv.
KEV HLOOV
Kaum cov kev kawm nrog kev phobia raug xaiv los ntawm kev tshaj xo thiab kev xa mus; lawv lub hnub nyoog yog 32.5 xyoo (SD = 10.4), thiab cov pab pawg muaj tsib tug txiv neej thiab tsib cov poj niam. Tag nrho cov ntsiab lus tau raug mob raws li kev txiav txim siab ntawm kev ntsuam xyuas kev mob nkeeg, tsis muaj kev sim siab, kev mob hlwb, kev nyuab siab, kev puas siab puas ntsws, kev nyuaj siab ntsws, kev tsis sib haum xeeb, kev nyuaj siab, kev noj qab nyob zoo, kev tsim txom lossis kev vam meej, kev puas hlwb lossis kev tsis sib haum xeeb, los yog tsev neeg keeb kwm ntawm tus mob schizophrenia. Xyoo kev noj qab haus huv kev sib piv, sib koom tes ntawm lub hnub nyoog thiab kev sib deev thiab tsis muaj teeb meem tam sim no los sis yav dhau los, tau txais los ntawm kev tshaj xo. Diagnoses tau txais kev pom zoo los ntawm kev siv Tus Kev Ntsuam Xyuas Kev Kho Mob rau DSM-IV Axis Kuv Teeb Meem (9).
Tag nrho cov ntsiab lus tau dawb ntawm psychotropic tshuaj rau tsawg kawg ib xyoos, thiab tshuaj ntsuam tau ua ntej luam roj. Tom qab qhia meej txog txoj kev tshawb fawb rau cov ntsiab lus, tau txais daim ntawv pom zoo tso cai.
Lub Liebowitz Social Kev Ntseeg (10) tau siv los ntsuas qhov phem ntawm kev phobia. D2 receptor losis tswvyim dabtsi yuav raug ntsuas los ntawm kev siv cov radiotracer [123Kuv] iodobenzamide ([123Kuv] IBZM) nrog ib qho photon emission computerized tomography, los ntawm kev siv ntawm lub bolus ntxiv qhov infusion txujci, raws li yav tas los piav (11). Ib qho qauv ntawm cheeb tsam-kev-paj ntaub ntawm qhov siv me me thiab qhov qauv yog siv los txheeb xyuas cov kev tshawb fawb. Txoj cai thiab sab laug striatal regions thiab oxipital regions tau muab tso rau ntawm cov duab cov ntsiab lus. Qhov kev cog lus tshwj xeeb tau muab xam raws li qhov sib txawv ntawm qhov kev ua si thiab kev ua ub ua no ntawm qhov sib npaug. [123Kuv] IBZM losis tswvyim dabtsi (hauv ml / g), sib thooj rau cov khoom ntawm tus dawb receptor ceev (Bmax, nyob rau hauv nM lossis picomoles per gram ntawm lub hlwb) thiab affinity (1 / KD, nyob rau hauv 1 / nM lossis milliliters plasma ib picomole ntawm [123Kuv] IBZM), raug xam raws qhov piv ntawm qhov tshwj xeeb ntawm kev sib txuam (hauv microcuries ib txoj kab ntawm lub paj hlwb) kom steady-state dawb unmetabolized ntshav tracer concentration (hauv microcuries ib milliliter plasma) (12).
Cov pab pawg neeg sib piv tau siv ob lub tailed unpaired t xeem nrog ib qho alpha ntawm 0.05. Kev los ntawm kev sib koom tes tau muaj feem xyuam nrog kev mob hnyav los ntawm kev hloov cov ntaub ntawv hloov (Spearman rank correlation).
KEV SIV
Tsis muaj qhov sib txawv hauv cov laus, kev sib deev, haiv neeg, kev kawm, kev muaj txij nkawm, los yog kev ua haujlwm.
Muaj qhov txawv txav ntawm [123Kuv] IBZM los ntawm kev sib tw ntawm cov pawg (t = 2.6, df = 18, p = 0.02), nrog rau cov neeg mob uas muaj kev phobia tsawg dua (txhais tau tias = 93.6 ml / g, SD = 29.8) dua li hauv kev sib piv ( txhais = 133.5 ml / g, SD = 38.2) (F1). Hauv cov pawg neeg phobia, muaj kev tsis sib haum xeeb ntawm kev sib raug zoo ntawm kev sib tw nrog peev xwm ntawm tag nrho cov qhab nia ntawm Liebowitz Social Anxiety Scale (rs= -0.59, N = 10, p = 0.07).
SIB THAM
Cov kev tshawb pom no hais tias feem ntau kev phobia tej zaum yuav muaj feem nrog D tsawg2 receptor losis tswvyim dabtsi hauv lub thev naus laus zis. Qes D2 receptor losis tswvyim dabtsi yuav ua tau raws li cov ntsiab lus uas tsis tshua muaj dopamine system ua si hauv kev phobia.
Txoj kev tshawb no tsuas yog siv tsawg tsawg xwb. Tsis tas li ntawd xwb, vim tsuas yog ib qho kev sim siab tshwj xeeb nkaus xwb nrog rau txhua yam kev kawm, D2 tus cwj pwm tsis txaus ntseeg thiab qhov tsis txaus siab yuav tsis raug ntsuas.
Cov kev tshawb pom tshwm sim los ntawm cov tsiaj ntawm cov kev tshawb fawb ntawm kev sib txawv hauv kev sib raug zoo, uas tau raug hais kom qhia cov cwj pwm txawv nrog tib neeg kev phobia (3). Piv txwv li, tsis ntev los no qhia txog kev tso pa tomography ntawm cov poj niam cynomolgus liab (13) pom qis qis D2 kev sib thooj hauv kev tswj hwm, zoo ib yam li peb nrhiav hauv kev phob thoob qhov. Cov tsiaj txhu ntawm txoj kev nyob sib haum xeeb tej zaum yuav yog ib tus qauv zoo rau kev nkag siab txog lub hlwb muaj qhov pib ntawm tib neeg kev phobia.
Qes D2 receptor thwj toob zoo li tsawg kawg nkaus rau cov kev phobia, tsis yog cov sawv cev ntawm ib qho tsis sib haum xeeb ntawm kev ntxhov siab lossis kev puas hlwb. D2 qhov kev tiv thaiv tsis tau pom muaj qis dua nyob rau hauv schizophrenia (14) lossis kev nyuab siab loj (15). Nws tau raug tshaj tawm hais tias yuav tsis muaj cov tshuaj phem ntau dua (16), uas feem ntau yuav comorbid nrog kev phobia (17).
Cov ntaub ntawv no qhia tias qes D2 receptor losis tswvyim dabtsi yuav tau txuam nrog kev phobia. Ua ke nrog cov txiaj ntsig los ntawm lwm qhov chaw, cov ntaub ntawv ntxiv rau cov pov thawj loj hlob uas D2 Receptor kev ua haujlwm modulates social cwj pwm nyob rau hauv tib neeg.
Tau txais Feb. 23, 1999; kev hloov kho tau txais lub Xya hli ntuj 13 thiab Aug. 27, 1999; txais Sept. 2, 1999. Los ntawm Kev Ntxhov Siab Tiv Thaiv Kev Nyuaj Siab thiab Lub Hlwb Raug Ntsuam Xyuas, Lub Tsev Kho Mob New York State Psychiatric; thiab Department of Psychiatry, Columbia University College ntawm cov kws kho mob thiab cov kws phais, New York. Tsis muaj cov reprints. Qhov chaw sau ntawv mus rau Dr. Schneier, Kev ntxhov siab vim lub tsev kho mob, Unit 69, New York State Psychiatric Institute, 1051 Riverside Dr., New York, NY 10032; [email tiv thaiv] (e-xa ntawv). Kev txhawb los ntawm cov nyiaj pab los ntawm Sycamore Foundation thiab los ntawm Solvay Pharmaceuticals thiab los ntawm NIMH Cov Neeg Txiav Txim Siab Siab MH-01603 rau Dr. Laruelle. Cov kws sau ntawv ua tsaug rau Kathy Rivera, Tami Edwards, Janine Rodenhiser, Ph.D., Suehee Chung, Mali Pratap, Ted Pozniakoff, Richard Weiss, Dan Schneider, thiab Analea Arevalo rau kev pabcuam.
DAIM NTAWV 1.
Dopamine D2 Tus Cwj Pwm Sib Ceg Npaum Muaj rau Cov Neeg Mob Nrog Cov Kev Pab Phaum Mob thiab Kev Noj Qab Nyob Zoo
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