Neuropsychopharmacology. 2015 Nov 10. doi: 10.1038 / npp.2015.340.
Mick Kuv1, Myers J1, Ramos AC1,2, Stokes PR1,3, Erritzoe D1, Colasanti A1,3,4, Gunn RN1,4, Rabiner EA4,5, Searle GE4, Waldman AD6, Parkin MC7, Brailsford AD7, Galduróz JC2, Bowden-Jones H8, Clark L9, Nutt DJ1, Lingford-Hughes AR1.
Abstract
Kev twv txiaj pathological yog kev puas siab ntsws thiab thawj qhov paub txog kev coj tus cwj pwm, nrog kev sib thooj rau kev quav yeeb tshuaj tab sis tsis muaj qhov cuam tshuam los ntawm cov tshuaj muaj feem xyuam rau lub hlwb hloov. Pathophysiology nyob rau hauv opioid receptor zog tau txais kev paub ntau ntxiv hauv cov quav tshuaj, muaj ntau dua-opioid receptor (MOR) muaj tshaj tawm hauv cawv, cocaine thiab opiate addiction. Kev ua tsis tau zoo, muaj kev pheej hmoo hla kev sib txuam, kuj tau pom tias cuam tshuam nrog MOR muaj ntau dua.
Lub hom phiaj ntawm txoj kev tshawb fawb no yog txhawm rau txheeb xyuas qhov pib MOR muaj peev xwm thiab muaj kev tawm opioid tso rau hauv kev twv txiaj kev twv txiaj (PG) siv [11C] carfentanil PET nrog kev sib tw tshuaj amphetamine. Kaum plaub PG thiab 15 cov neeg ua haujlwm noj qab haus huv (HV) tau kuaj pom ob [11C] carfentanil PET kev soj ntsuam, ua ntej thiab tom qab qhov ncauj tswj hwm ntawm 0.5 mg / kg ntawm d-amphetamine. Cov kev hloov hauv [11C] carfentanil kev khi ntawm qhov pib thiab tom qab-amphetamine scans (ΔBPND) tau txheeb xyuas hauv 10 cov cheeb tsam ntawm kev txaus siab (ROI). MOR muaj tsis txawv ntawm pawg PG thiab HV. Raws li pom yav tas los, qhov ncauj kev sib tw ntawm cov tshuaj amphetamine tau ua rau muaj qhov txo qis hauv [11C] carfentanil BPND hauv 8 / 10 ROI hauv HV.
PG pom hais tias tseem ceeb tshaj plaws ntawm kev tso tshuaj opioid sib piv nrog HV. PG kuj tseem pom tias muaj kev lom zem rau cov tshuaj amphetamine los vim muaj kev zoo siab thiab piv txwv li piv nrog HV. Tshawb nrhiav tshawb xyuas tau qhia tias lub zog tsis ua hauj lwm zoo txuas nrog caudate lub hauv paus BPND hauv PG nkaus xwb. Txoj kev tshawb fawb no muab cov pov thawj thawj zaug ntawm blunted endogenous opioid tso tawm hauv PG. Peb qhov kev tshawb pom muaj raws li cov pov thawj loj zuj zus hais tias dysregulation ntawm endogenous opioids yuav muaj lub luag haujlwm tseem ceeb hauv pathophysiology ntawm kev muaj yees.
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