Muaj ntau hluas txiv neej nrog erectile dysfunction wrongly xav tias tsawg testosterone yuav tsum tau mus blame. Qhov no yog kis tsis zoo li tsawg tsawg testosterone yuav tsum tau ua kom tiav ib qho erection, ED kev tshawb fawb qhia tsis muaj correlation nrog testosterone, thiab T supplementation no tsuas siv tau cov neeg mob hypogonadal loj xwb.
Plasma testosterone theem ntawm cov neeg ua haujlwm hauv kev sib deev thiab cov txiv neej tsis nyiam.
Tus poj niam txiv neej pw. 1980 Oct;9(5):355-66.
Schwartz MF, Kolodny RC, Masters WH.
Abstract
Qib Testosterone Plasma ntau ntau hauv ib pawg ntawm 341 tus txiv neej nrog kev sib daj sib deev tau muab piv rau cov txiv neej xyoo 199 uas muaj kev ua haujlwm sib deev. Txhua yam kev kawm yog cov neeg koom rau hauv 2-lub lis piam sib zog kho kev sib deev kho poj niam ntawm Masters & Johnson Institute. Kev txiav txim siab Testosterone tshuaj yog tsim los siv radioimmunoassay txoj kev tom qab kem chromatography; tag nrho cov ntshav tau txais nyob rau hnub thib ob ntawm kev kho thaum 8:00 txog 9:00 sawv ntxov tom qab kev pw ib hmos. Cov theem ntawm cov testosterone hauv cov txiv neej uas muaj kev sib deev ua haujlwm (txhais tias 635 ng / dl) tsis txawv ntawm testosterone qhov tseem ceeb ntawm cov txiv neej ua neej tsis zoo (txhais hais tias 629 ng / dl). Txawm li cas los xij, cov txiv neej nrog thawj qhov tsis muaj zog (N = 13) muaj qib testosterone ntau dua li cov txiv neej muaj kev tsis taus (N = 180), nrog cov theem ntawm 710 thiab 574 ng / dl, feem (p <0.001). Qib testosterone qib qis rau cov txiv neej nrog ejaculatory imcompetence yog 660 ng / dl (N = 15), thaum rau cov txiv neej nrog lub cev yug ntxov ua ntej qhov phem txhais tau tias yog 622 ng / dl (N = 91). Plasma testosterone cov ntsiab lus tsis cuam tshuam nrog kev kho qhov tshwm sim tab sis tau txheeb cais tsis zoo nrog lub hnub nyoog ntawm cov neeg mob.
Pituitary gonadal system muaj nuj nqi rau cov neeg mob uas muaj mob impaired erectile thiab ntxov ntxov ejaculation.
Tus poj niam txiv neej pw. 1979 Jan;8(1):41-8.
Pirke KM, Kockott G, Aldenhoff J, Besinger U, Feil W.
Abstract
Tus mob pituitary testicular tau kawm hauv cov txiv neej nrog kev mob hlwb tsis zoo. Yim tus neeg mob ua rau lub cev qoj ib ce muaj hnub nyoog 22–36 xyoo, yim tus txiv neej muaj kev phom sij mob erectile muaj hnub nyoog 29-55 xyoo, thiab 16 tus txiv neej uas ntxov ntxov muaj hnub nyoog 23–43 xyoo tau kawm. Cov pab pawg kawg tau muab faib ntxiv ua ob pawg: E1 (n = 7) cov neeg mob uas tsis muaj thiab E2 (n = 9) cov neeg mob uas muaj kev ntxhov siab thiab zam kev coj ua tsis zoo rau kev ua si. Kaum tus txiv neej laus hnub nyoog 21-44 xyoo ua pab pawg tswj hwm. Kev kuaj mob tau ua tom qab kev soj ntsuam mob hlwb thiab lub cev. Cov neeg mob tsis txaus siab feem ntau ntawm kev ploj tuag tsis tau muab xam rau hauv txoj kev tshawb nrhiav. Tau kaum cov ntshav sib law liag tau ntau tshaj li ntawm 3 hr los ntawm txhua tus neeg mob. Luteinizing hormone (LH), tag nrho testosterone, thiab dawb (tsis muaj protein ntau) testosterone raug ntsuas. Tshaj tawm kev tshwm sim tsis muaj qhov sib txawv ntawm cov neeg mob thiab cov kev tswj ntawm ib txwm muaj.
Plasma testosterone thiab testosterone binding affinities rau cov txiv neej nrog impotence, oligospermia, azoospermia, thiab hypogonadism.
Br Med J. 1974 Mar 2;1(5904):349-51.
Abstract
Txhais tau hais tias plasma testosterone qib (+/- SD), siv Sephadex LH-20 thiab kev sib tw protein sib khi, yog 629 +/- 160 ng / 100 ml rau ib pawg ntawm 27 tus txiv neej ib txwm laus, 650 +/- 205 ng / 100 ml rau 27 cov txiv neej tsis muaj zog nrog cov txiv neej sib deev theem nrab, 644 +/- 178 ng / 100 ml rau 20 tus txiv neej nrog oligospermia, thiab 563 +/- 125 ng / 100 ml rau 16 azoospermic txiv neej. Tsis muaj ib yam ntawm cov nqi sib txawv. Rau 21 tus txiv neej nrog kev ua pov thawj hauv hypogonadism txhais tau tias plasma testosterone (+/- SD), ntawm 177 +/- 122 ng / 100 ml, sib txawv sib txawv (P <0.001) los ntawm tus txiv neej ib txwm muaj.Qhov nruab nrab testosterone binding affinities (raws li ntsuas los ntawm cov txiaj ntsim ntawm cov ntshav siab uas yuav tsum tau mus khi 50% ntawm (3) H-testosterone tracer) zoo ib yam li cov txiv neej, tsis muaj zog, thiab cov txiv neej oligospermic. Txawm hais tias qis dua rau azoospermic txiv neej qhov txawv tsis txawv (P> 0.1). Rau 12 ntawm 16 tus txiv neej hypogonadal cov testosterone sib tsoo sib raug zoo yog qhov qub, tab sis tsa cov kev sib koom tes sib luag, zoo ib yam li cov uas pom muaj nyob hauv cov pojniam laus lossis cov tub hluas ua ntej (txog ob zaug tus neeg laus qib txiv neej qib), tau pom nyob hauv plaub kis ntawm kev ncua pub pub dawb. Cov kev tshawb pom no los pab qhia seb yog vim li cas androgen therapy yog feem ntau useless rau cov kev kho mob ntawm impotence.
Testosterone puas muaj lub luag haujlwm nyob rau hauv kev ua haujlwm erectile?
Am J Med. 2006 May;119(5):373-82.
PURPOSE:
Txawm tias muaj lub luag haujlwm zoo los ntawm testosterone hauv kev txhawb nqa libido, nws cov nyiaj tshev pes tsawg rau cov txiv neej tseem tsis meej. Lub hom phiaj tseem ceeb ntawm kev txheeb xyuas no yog kom paub meej txog lub luag haujlwm ntawm testosterone hauv kev ua haujlwm erectile thiab ntsuam xyuas nws cov nqi kho rau cov txiv neej nrog erectile kawg (ED).
KEV HLOOV:
Tshawb xyuas txog cov ntaub ntawv tseem ceeb (Lus Askiv, Fabkis, thiab lus Spanish) ntawm 1939 mus rau lub Rau Hli 2005 tau siv cov ntaub ntawv cov ntaub ntawv los ntawm MEDLINE, cov phau ntawv endocrinology phau ntawv, thiab kev tshawb nrhiav ntawm qhov cross-references los ntawm cov khoom qub thiab kev txheeb xyuas. Cov kev soj ntsuam cov kev mob, kev tshawb xyuas tsiaj, cov ntaub ntawv qhia, kev ntsuam xyuas, thiab cov txheej txheem ntawm cov koom haum tseem ceeb.
COV LUS QHIA:
Cov kev tshawb nrhiav tsiaj txhu thiab ua ntej tshaj tawm hais tias testosterone yuav pab tau erection los ua tus vasodilator ntawm rab qaum arterioles thiab cavernous sinusoids. Tom qab castration, feem ntau, tab sis tsis yog tag nrho, cov txiv neej muaj ib feem los yog tag nrho tsis erection. Hypogonadism tsis yog ib qho kev tshawb pom hauv ED, tshwm sim hauv 5% ntawm tus neeg mob, thiab feem ntau, tsis muaj kev sib koom ntawm cov kev sib txawv ntawm serum testosterone, thaum tam sim no hauv qib qis los sis tsis tshua muaj me ntsis, thiab kev ua haujlwm erectile.
Feem ntau cov kev sim siv cov testosterone rau kev kho mob ntawm ED hauv cov pojniam cov pojniam muaj teeb meem ntawm cov qauv teebmeem thiab qhia txog kev tsis haum xeeb, tab sis txhua yam, qhia tias testosterone yuav zoo dua rau cov placebo. Erectile muaj nuj nqi ntau dua los txhim kho nrog testosterone therapy rau cov neeg mob uas muaj degrees loj heev ntawm hypogonadism.
Kev ntsuam xyuas kev kuaj pom tau tias yuav ua rau cov lus teb rau cov phosphodiesterase 5 (PDE5) ua rau cov txiv neej thiab cov txiv neej uas muaj cov qes ntshav tsawg. Kev ntsuas kev ntsuas yav dhau los ntawm kev soj ntsuam txhua txhua hnub yog kev ncaj ncees thiab yooj yim rau kev ntsuam xyuas androgenecity, tab sis kev ntsuas dawb los yog bioavailable testosterone raug pom zoo rau cov kev mob uas hloov theem ntawm kev sib deev-hormone-binding globulin (SHBG), xws li cov laus thiab hauv kev rog.
TXHEEJ XWM:
Muaj cov ntaub ntawv tawm tswv yim hais tias nyob rau hauv feem ntau cov txiv neej circulating theem ntawm testosterone, zoo hauv qab qhov ntau ntau, yog qhov tseem ceeb rau qub erection thiabcov kaus mom ntau dua cov ntshav siab testosterone yuav tsis muaj kev cuam tshuam loj rau kev ua haujlwm erectile. Kev kuaj ntshav rau cov txiv neej nrog rau ED yog tsim nyog los txheeb xyuas cov neeg mob hypogonadism thiab qee qhov mob me me mus rau qib hypogonadism, uas yuav tau txais kev pab los ntawm kev kuaj tshuaj.
Qhov tseem ceeb ntawm hypogonadism nyob rau hauv erectile kawg.
Ntiaj teb J Urol. 2006 Dec;24(6):657-67.
Abstract
Txhawm rau saib xyuas lub luag haujlwm thiab qhov tseem ceeb ntawm hypogonadism, txhais tias yog ib qib qis testosterone (T), nyob rau hauv erectile kawg (ED). Tshawb xyuas ntawm cov ntaub ntawv.
Ntshauv T yog qis dua 3 ng / ml nyob rau hauv 12% ED cov neeg mob, nrog rau 4% ua ntej thiab 15% tom qab hnub nyoog ntawm 50. Kev hloov kev tshawb fawb rau cov txiv neej uas muaj cov hypogonadism ua rau pom tias muaj kev sib deev thiab arousal, nrog rau kev sib deev ntau zaus thiab kev paub daws teeb meem yog T-siab. Kev puas hlwb erections yog ib nrab T-nyob. Cov teebmeem ntawm T ntawm qhov kev ua haujlwm ntawm kev sib deev yog dose-nyob mus txog theem ntawm cov neeg mob, tab sis muaj kev sib txawv ntawm cov neeg, xws li 2 rau 4.5 ng / ml. Yuav tsum muaj pov thawj ntau ntxiv kom paub tseeb tias T tseem ceeb ntawm T ntawm cov leeg pob txha ntawm cov leeg hlwb hauv cov txiv neej thaum nws yog cov xwm txheej hauv cov tsiaj.
Tsis muaj kev ywj pheej ntawm T nrog ED tau pom nyob hauv kev tshawb xyuas epidemiological. Raws li kev txhawj xeeb ntawm kev soj ntsuam, tab sis ib qho kev ntsuam xyuas ntawm cov kev ntsuam xyuas randomized uas tau tsim los ntawm T kev kho kom zoo tas rov qab ua haujlwm rau cov neeg laus hypogonadal nrog T hauv 3.46 ng / ml, qhov teebmeem ntawm txoj kev kho no feem ntau tsis zoo siab thaum siv cov laus hauv cov laus pab tswv yim rau ED uas yog tom qab kuaj pom tias muaj hypogonadism tom qab niaj hnub T ntsuas. Cov kev txom nyem no tej zaum yuav piav qhia los ntawm kev sib koom siab ntawm kev sib tw, thiab los ntawm qhov tseeb tias ED nws tus kheej yuav ua rau kev hypogonadism.
Kev siv tshuaj kho T thiab PDE5 inhibitor (PDE5I) yuav kho tau zoo rau cov kab mob hypogonadal ED thaum cov kev kho T tsis kho. Txawm li cas los xij, yuav tsum muaj pov thawj ntau ntxiv kom paub tseeb tias qhov tsawg kawg ntawm T yuav tsum tau ua kom tiav ntawm PDE5I hauv qee tus txiv neej, txij li thaum lub PDE5I tau kho tag nrho cov txiv neej ua poj niam. Txawm tias tus T qis qis tsis yog ib txwm ua rau ntawm ED rau hypogonadal ED cov neeg mob, nws tseem muaj txiaj ntsim zoo rau kev kuaj ntshav rau hauv ED. Tus T qis qis qis pom zoo rau 3 lub hlis ntawm T kev kho mob, ua ntej sib txuas nrog PDE5I yog T txoj kev kho ib leeg tsis tuaj yeem.
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