FA'AMATALAGA: A'O fai mai le su'esu'ega o le neural circuit ma faiga o vaisu e matua felavasa'i ma vaisu o amioga.
Curr Pharm Des. 2011;17(12):1158-67. Blum K, Liu Y, Shriner R, Gold MS.
puna
Matagaluega o Psychiatry, ma McKnight Brain Institute, Iunivesite o Florida, Kolisi o Vailaau Faafomai, Gainesville, Florida, ISA. [imeli puipuia]
ABSTRACT
Neural circuits o loʻo aʻafia i fualaau faʻasaina, manaʻo ma toe faʻafoʻi faʻatasi ma i latou o loʻo aʻafia i taui masani ma faʻamalosia e pei o meaʻai. O le faʻaalia i faʻamatalaga e fesoʻotaʻi ma vailaʻau i mea ua fai ma vaisu e mafua ai le tuʻinanau o vailaʻau ma le faʻaogaina o le faʻaogaina o taʻaloga tutotonu lea e iloa e faʻatalanoaina le toe faʻafoʻiina o le suʻeina o vailaʻau i manu faʻataʻitaʻiga o le toe faʻafoʻi. O fa'asologa fa'aitulagi fa'agaioiga fa'atusa e tupu i tagata e tali atu i fa'ailoga e feso'ota'i ma mea'ai. E le gata i lea, o fualaau faasaina ma mea'ai e le gata e fa'agaoioia ai vaega masani o le neuroanatomical ae fa'apena fo'i i polokalame fa'aalia fa'atupu fa'atupu fa'atulafonoina i totonu o nei vaega fa'asoa.
O fa'ailoga e va'ai ai le maua o mea'ai e fa'atonuina mamana o le mana'o fa'apea fo'i ma le su'eina o mea'ai ma le taumafaina. O le faʻatonutonuina o le tele o uluaʻi kenera i mamanu tulaga ese i totonu o fesoʻotaʻiga corticostriatal, thalamic, ma hypothalamic e taʻu mai ai o meaʻai e mafai ona suia malosi le gaioiga o le neuronal i vaega e faʻatalanoaina le tuʻufaʻatasia o lagona, cognition, faʻamalosi, ma le faʻatonutonuina o le paleni malosi. O le dopaminergic, enkephalinergic, ma fos gene expressions o auala fa'atulafonoina fa'ale-aganu'u taua mo amioga tu'inanau mea'ai. O se faaupuga faamalu e fa'amatala ai fa'asologa masani masani o le tele o amioga fa'amalosi, fa'amalosi ma fai ma vaisu o le Reward Deficiency Syndrome (RDS). O tagata taʻitoʻatasi o loʻo i ai le le lava o serotonergic ma / poʻo le dopaminergic receptors ma le faʻateleina o le synaptic dopamine catabolism, ona o le maualuga o le catabolic genotype o le COMT gene, e faʻamoemoe e togafitia e le tagata lava ia soʻo se vailaʻau poʻo amioga e faʻagaoioia ai le faʻamalolo o le dopamine e aofia ai le ava malosi, opiates, psychostimulants, nicotine, kulukose, taaloga faitupe, feusuaiga, ma e oo lava i le tele o taaloga i luga ole laiga, ma isi. Ma le mea mulimuli, o le faʻaaogaina o le umi o le dopaminergic activation approach o le a iu ai ina taʻitaʻia se faiga masani saogalemu ma aoga e togafitia ai amioga RDS e aofia ai meaʻai faʻafefe ma amioga tuʻinanau.
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