Neuropsychopharmacology. 2017 Me 2. doi: 10.1038 / npp.2017.88.
Hamilton PJ1, Burek DJ1, Lombroso SI2, Neve RL3, Robison AJ4, Nestler EJ1, Heller EA2.
lē faʻatino
Ole faʻalavelave faʻalavelave faʻaagafesootai e faʻatonutonuina ai le faʻaaliga o le Fosb i le nucleus accumbens (NAc) e faʻaleleia ai le faʻaputuga faʻapitoa o le ΔFosB i totonu o le lua medium spiny neuron (MSN) subtypes i lenei itulagi. ΔFosB o loʻo faʻaosoina faʻamalosi i D1-MSNs i le NAc o isumu faʻamalosi, ma i D2-MSNs o isumu faigofie. Ae ui i lea, e itiiti se mea e iloa e uiga i taunuuga o ia filifiliga filifilia, aemaise ile D2-MSNs. O lenei suʻesuʻega na suʻesuʻeina ai le faʻaogaina o le cell-type control of the endogenous Fosb gene i le NAc e faʻatonutonu ai le faʻalavelave i faʻalavelave faʻaleagaina lautele. Histone post-translational modifications (HPTMs) sa fa'atatau tonu ile Fosb ile fa'aogaina o polotini zinc-tamatamai (ZFPs). Fosb-ZFPs na faʻapipiʻiina i le transcriptional repressor, G9a, lea e faʻamalosia ai le methylation histone poʻo le activator transcriptional, p65 lea e faʻamalosia ai le faʻaogaina o le histone. O nei ZFPs na faʻaalia i D1- vs D2-MSNs e faʻaaoga ai le faʻamatalaga viral faʻalagolago i le NAc o isumu transgenic mo Cre-recombinase i nei MSN subtypes. Matou te iloa o le faʻalavelave faʻalavelave e faʻafeagai le faʻatonutonuina e le ituaiga cell cell ma HPTM faʻatatau. Matou te lipoti atu o le Fosb-targeted histone acetylation i D2-MSNs poʻo le histone methylation i D1-MSNs e faʻamalosia ai se faʻalavelave faʻalavelave, faʻalavelave-pei o le phenotype, ae o le methylation histone i D2-MSNs poʻo le acetylation histone i D1-MSNs e faʻateleina ai le faʻamalosia i faʻalavelave faʻaagafesootai e pei o fuaina e ala i amioga fegalegaleai ma le fiafia i le sucrose. O lenei galuega o loʻo tuʻuina atu ai le faʻataʻitaʻiga muamua o le faʻaogaina o le cell-ma gene-specific o suiga faʻasolopito o loʻo faʻataʻitaʻiina faʻapitoa faʻasologa o tusitusiga e pulea ai amioga faʻalavelave faʻaagafesootai. O lenei epigenetic faʻataʻitaʻiga faʻataʻitaʻiga, lea e toe faʻaleleia ai suiga o le physiological i faʻamatalaga o kenera, e faʻaalia ai le eseesega manino i le faʻaleagaina faʻaagafesootai phenotype faʻaosoina e Fosb manipulation i MSN subtypes.
PMID: 28462942
FAIA: 10.1038 / npp.2017.88
;
