Neuropharmacology. 2016 Me 2. oso: S0028-3908 (16) 30185-X. Tui: 10.1016 / j.neuropharm.2016.04.045.
Wang J1, Bastle RM2, Faʻasalaga3, Hammer RP Jr1, Neisewander JL2, Nikulina EM4.
lē faʻatino
O le faʻamamafa ose mea taua tele le faʻaogaina o vailaʻau. Faʻaletonu vafealoaʻi faʻatoʻilaloina popole faʻalauteleina faʻafitauli fualaʻau lava-pulega (SA) ma siitia maualuga faiaʻoga-mafuaʻaga neurotrophic vaega (BDNF) faʻaaliga i le ventral tegmental eria (VTA) i isumu. Intra-VTA BDNF o le soʻona faʻamatalaina faʻalauteleina e faʻalauteleina ai agafesoʻotaʻi-faʻatupuina koluse-sensitization i psychostimulants ma faʻamalosia ai nucleus accumbens (NAc) ΔFosB faʻaaliga. O le mea lea, faʻateleina VTA BDNF ono mimic pe faʻateleina le atinaʻeina o le faʻaogaina o fualaʻau amio-fesoʻotaʻi mulimuli ane popolega lautele. Ina ia suʻesuʻeina lenei manatu, o le siama e fesoʻotaʻi ma adeno (AAV) na tuʻuina i totonu o le VTA e soona faʻaali ai le GFP lava ia (control) poʻo le GFP + BDNF. O leoleoga na faʻatautaia pe faʻailoaina i faʻalavelave faʻafuaseʻi aʻo le i amataina le cocaine SA. O le SA mauaina ma le tausiga o vaega na mulimulitaʻia faʻataʻitaʻiga i luga o le alualu i luma fua (PR) faʻatulagaina o le faʻamalosia o cocaine, ma i le taimi o le 12-taimi ulufale "binge" cocaine SA sauniga. O le BDNF ma le ΔFosB na faʻatulagaina postmortem i itulagi o le mesocorticolimbic circuitry faʻaaoga ai le immunohistochemistry. O le soʻona faʻatamaia o le faʻamalosi tino faʻateleina cocaine taumafaina i luga o le PR faasologa, e tusa lava poʻo le a le togafitiga o siama. E ui lava o le mafatiaga na faʻateleina ai le taumafaina i le taimi o le 12-h binge session, o agafesoʻotaʻi-faiaina isumu na mauaina le VTA BDNF ova faʻamatalaga na faʻaalia ai le sili atu o fualaʻau kokain pe a faʻatusatusa i le GFP-stress kulupu. Peitai, o le VTA BDNF o le soʻona faʻaalia o faaupuga na te leʻi suia ai le inuina o le pia. O le faʻamatalaga a le BDNF i le VTA na faʻamaonia lelei foi i le aofaʻi o le cocaine i le taimi o le sauniga. VTA BDNF faʻateleina faʻamatalaga faʻateleina ΔFosB faʻaaliga i le NAc, ae le o le dorsal striatum. Lenei matou te faʻaalia o le VTA BDNF o le soʻona faʻamatalaina faʻateleina umi-ulufale cocaine taumafaina, ae na o lalo o faigata tulaga. O le mea lea, faʻateleina le faʻaalia o le VTA-BDNF atonu e avea ma tagata faʻafaigofie mo le faʻatuputeleina o le mafaufau i amioga faʻataʻitaʻi e faʻatatau i lalo o tulaga e puʻeina ai le malosi o le tagofia o fualaʻau.
;