Protein Kinase G Faʻatonuina le Dopamine Faʻasalaga, ΔFosB Faʻaaliga, ma le Locomotor Gaioiga A maeʻa le faʻaaogaina o Cocaine Administration: Faʻaaogāina o Dopamine D2 Receptors (2013)

Neurochem Res. 2013 Apr 13.

Lee DK, Oh JH, Shim YB, Choe ES.

puna

Matagaluega o Biological Sciences, Pusan ​​National University, 63-2 Pusandaehak-ro, Kumjeong-gu, Pusan, 609-735, Korea.

lē faʻatino

Protein kinase G (PKG) activation ua aafia i le faʻatulafonoina o synaptic plasticity i le faiʻai. O lenei suʻesuʻega na faia e faʻamautinoa ai le aʻafia o PKG-fesoʻotaʻi dopamine D2 (D2) i le faʻatulafonoina o le faʻasaʻolotoina o le dopamine, expressionFosB faʻaaliga ma le gaioiga a le locomotor i le tali atu i le faʻaalia pea o le cocaine. Faʻasolosolo tuiina o cocaine (20 mg / kg), tasi i le aso mo le fitu aso sosoʻo, faʻateleina le cyclic guanosine monophosphate (cGMP) ma extracellular dopamine concentrations i le dorsal striatum. O le taofiofia o le neuronal nitric oxide synthase (nNOS), cGMP poʻo PKG ma le faʻaosofiaina o D2 talipapa na faʻaititia ai le faʻateleina o le cocaine-faʻatupuina faʻateleina i le faʻatotoina o le dopamine. O faʻaiʻuga na maua e le tuʻufaʻatasia o le nNOS, cGMP poʻo le PKG taofi faʻatasi ma le faʻaosofia o D2 taliaina. Faʻatusatusa i nei faʻamaumauga, PKG taofiofia, D2 talimalo faʻaosofia, ma tuʻufaʻatasia PKG taofi faʻatasi ma le faʻaosofia o D2 talimalo faʻaititia le faʻaauauina faʻateleina kokainina-faʻaosofia i le osFosB faʻaaliga ma locomotor gaioiga.

O nei suʻesuʻega ua fautua mai ai o le pulea o le tali a le D2 e le PKG faʻamalosia pe a maeʻa ona faia pea le cocaine e nafa ma le toefaʻailogaina o le tuʻuina atu o le dopamine ma suiga tumau i le faʻasologa o le gene i faʻamalama dopamine ma gamma-aminobutyric acid ole nema o le tuatusi. O lenei tulafono faatonutonu e mafai ona fesoasoani i suiga o amioga i le tali atu i le toe faʻaalia i le cocaine.