Eseesega o feusuaiga i tali faaosofia i gaʻo meaʻai i Suria (2015)

Tamaʻitaʻi e sili atu nai lo tamaloloa e faʻaalia faʻamalosia faʻafitauli (eg, anhedonia ma le popole) ma le faʻatapulaʻaina togafitiga, ma le soona faʻaaoga o gaʻo maualuga "meaʻai faʻamalieina" e faʻaleleia atili faʻatupuina faʻalavelave. O le mea e leaga ai, o neurobiological faʻavae mo feusuaʻiga eseesega i faʻatosina faʻalavelave ma a latou tali i meaʻai gaʻo e le malamalama lelei i ai. Ina ia fesoasoani e faʻapipiʻi ia avanoa taua o le malamalama, na matou suʻesuʻeina amio ma tali atu i neurobiological i meaʻai gaʻo i se hamster faʻataʻitaʻi o fafine-faʻaituau faʻaosofia gaioiga. E fesoʻotaʻi ma fale faʻaagafesootai, vavae esega faʻaagafesoʻotaʻi faʻaititia le hedonic drive i se fou amioga assay, o le faʻailoga suʻesuʻe fiafia (RIP) suʻega. Fluoxetine poʻo desipramine togafitiga mo 21, ae le o 7, aso faʻaleleia atili RIP suʻega gaioiga. Farmacologic faʻapitoa i lenei suʻega na faʻaalia e le le tali atu i le diazepam, tracazolate, propranolol, poʻo le naltrexone. I le suʻega e fesoʻotaʻi i le popolevale / suʻesuʻe feteʻenaʻiga (AFEC), o le tuʻufaʻatasia o agafesoʻotaʻi na atili ai ona leaga le latency e ai meaai sili ona lelei i lalo o tulaga popole, ae le o totonu o pa o fale. O le vavaeeseina o agafesootai na faaititia ai foi le mamafa maua, taumafaina o meaai, ma le fiafia ae siitia le malosi o tupe faaalu, iloiloina e le lelei lelei ma le tuusao calorimetry. E le gata i lea, o le fafagaina pea o gaʻo maualuluga na faʻaleleia atili ai le tali atu a le anhedonic ma le popole i le teteʻa, ae maise lava i fafine. I le faʻaosofia-faʻatosina nucleus accumbens, fafine, ae le o tama, faʻaalia se teteʻaga-faʻaosofia popole-faʻaititia faʻaititia i le Creb1 mRNA tulaga ma le faʻaititia e fesoʻotaʻi i le hedFosb mRNA. O gatasi ma ona vailaʻau faʻafitauli antidepressant- ma le popole i amioga, o le fafagaina maualuga-gaʻo na faʻatupuina ai le taua o le Creb1 ma le ΔFosb mRNA i tamaʻitaʻi. O le isi togi faʻailoga taua, Tlr4 mRNA, na siitia i fafine e ala i le fafagaina maualuga-gaʻo. O nei taunuʻuga faʻaalia ai o le vavaeeseina lautele o hamsters maua ai se tala fou faataitaiga o feusuaiga-faʻalagolago comedbid anhedonia, popolega, ma anorexia, ma aafia accumbal CREB, ΔFosB, ma TLR4. E le gata i lea, o iʻuga e faʻamaonia ai se suʻega fou mo le tumau o le antidepressant aoga.

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