Curr Pharm Des. 2017 Aokuso 22. Tui: 10.2174 / 1381612823666170823101713.
Blum K1, Thanos PK2, Wang GJ3, Fepuari M1, Demetrovics Z4, Faʻalelei IJ5, Braverman ER6, Baron D.6, Le Badgaiyan RD7, Gold MS8.
lē faʻatino
O le lapopoʻa o loʻo faʻaleagaina ai soifua o le sili atu i le 300 miliona tagata i le lalolagi atoa ma le faʻatumauina o le soifua maloloina mamafa e faʻaaogaina ai metotia lauiloa o le paʻu o pauna o se galuega faigata tele. O le puleaina ole faʻafitauli o le lapoʻa e foliga mai e mafai ona ausia, pe a oʻo i se malamalama lelei e atiaʻe, o le aoga o le tatou genome i vailaʻau / nutrient tali. Fuafuaga faʻailoa mai i lenei malamalamaaga o le nutrepigenomics ma le neurogenetics i le togafitia ma le puipuia o le metabolic syndrome ma le lapoʻa e aofia ai le feololo o le mRNA faʻaaliga e DNA methylation, ma le taofiofia o le histone deacetylation. Faʻavae i luga o le tagata lava ia teuga foliga le lava metabolic ala e mafai ona faʻatatauina epigenetically e, mo se faʻataʻitaʻiga, o le tuʻuina atu o meaʻai faʻaopopo e aofia ai fitokimia, vitamini, ma taua aoga amino acid. Faʻapea foi, le chromatin fausaga o le lolomiina genes e faʻatonutonu ai meaʻai i taimi o fetal atinae mafai ona toe faʻaleleia. Auala e afaina ai le faʻailoaina o le dopamine, molimoli felauaʻiga ma le faʻalauteleina o neula e aofia ai i nei taʻiala. O le lapoʻa o se tamaʻi vaega o le Reward Deficit Syndrome (RDS) ma nei auala fou i le togafitia ma le puipuia o le puta tele na faʻaleleia atili ai le faʻatinoina o le dopamine. E le naʻo se mataupu o le faʻailo o le gastrointestinal e fesoʻotaʻi i hypothalamic peptides, ae i se isi itu, saili ni auala fou e faʻaleleia ai ventral tegmental area (VTA) dopaminergic function ma homeostasis.
KEYWORDS: Meaʻai ma vailaʻau faʻasaina; epigenetics. ; hypothalamic-gut-axis; neurogenetics; tulafono faʻatonu-dopamine; taui le atoatoa lelei syndrome (RDS)
PMID: 28831923
FAIA: 10.2174/1381612823666170823101713
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